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Three cases of ectopic sphenoid sinus pituitary adenoma.
Folia Neuropathol. 2017; 55(1):60-66.FN

Abstract

Introduction: Ectopic sphenoid sinus pituitary adenoma is a rare tumour originating from embryologic remnants of Rathke's pouch. Although it is considered a clinically benign neoplasm, necrosis is encountered in 25% of cases and it can invade adjacent bone structures. Aims: To establish clinical, radiological and histopathological features of ectopic sphenoid sinus pituitary adenoma. Material and methods: Analysis of three cases: two females and one man, aged 61-70. Results: One patient presented with a unilateral hearing loss, the other two with headache and vertigo. They all suffered from type 2 diabetes mellitus. Neurological examination revealed no abnormality. Radiological imaging showed a sphenoid sinus space-occupying soft-tissue lesion with bone erosion in 2 cases and empty sella in 2 patients whereas one had a normal pituitary gland. All were operated on via the transnasal approach. Total resection was achieved in one patient and subtotal in two; in two cases we observed intact sellar dura and in one intact sellar floor. Histopathology showed immunoreactivity for synaptophysin in all cases and cytokeratin in two. The Ki-67 index was less than 2%. Immunohistochemical staining demonstrated growth hormone cells in all cases whereas prolactin and adrenocorticotropin in two. The patients were discharged home in good condition with no neurological deficits. Conclusions: Ectopic sphenoid sinus pituitary adenoma should always be considered in differential diagnosis of sphenoid sinus lesion in the elderly, especially in coexistence with empty sella or type 2 diabetes mellitus. Since ectopic sphenoid sinus pituitary adenoma is a benign lesion, surgical removal is an effective treatment. .

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28430293

Citation

Bobeff, Ernest Jan, et al. "Three Cases of Ectopic Sphenoid Sinus Pituitary Adenoma." Folia Neuropathologica, vol. 55, no. 1, 2017, pp. 60-66.
Bobeff EJ, Wiśniewski K, Papierz W, et al. Three cases of ectopic sphenoid sinus pituitary adenoma. Folia Neuropathol. 2017;55(1):60-66.
Bobeff, E. J., Wiśniewski, K., Papierz, W., Stefańczyk, L., & Jaskólski, D. J. (2017). Three cases of ectopic sphenoid sinus pituitary adenoma. Folia Neuropathologica, 55(1), 60-66. https://doi.org/10.5114/fn.2017.66714
Bobeff EJ, et al. Three Cases of Ectopic Sphenoid Sinus Pituitary Adenoma. Folia Neuropathol. 2017;55(1):60-66. PubMed PMID: 28430293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three cases of ectopic sphenoid sinus pituitary adenoma. AU - Bobeff,Ernest Jan, AU - Wiśniewski,Karol, AU - Papierz,Wielisław, AU - Stefańczyk,Ludomir, AU - Jaskólski,Dariusz Jan, PY - 2017/4/22/entrez PY - 2017/4/22/pubmed PY - 2018/2/28/medline KW - ectopic pituitary adenoma KW - empty sella KW - neuroendocrine markers KW - plurihormonal KW - sphenoid sinus SP - 60 EP - 66 JF - Folia neuropathologica JO - Folia Neuropathol VL - 55 IS - 1 N2 - Introduction: Ectopic sphenoid sinus pituitary adenoma is a rare tumour originating from embryologic remnants of Rathke's pouch. Although it is considered a clinically benign neoplasm, necrosis is encountered in 25% of cases and it can invade adjacent bone structures. Aims: To establish clinical, radiological and histopathological features of ectopic sphenoid sinus pituitary adenoma. Material and methods: Analysis of three cases: two females and one man, aged 61-70. Results: One patient presented with a unilateral hearing loss, the other two with headache and vertigo. They all suffered from type 2 diabetes mellitus. Neurological examination revealed no abnormality. Radiological imaging showed a sphenoid sinus space-occupying soft-tissue lesion with bone erosion in 2 cases and empty sella in 2 patients whereas one had a normal pituitary gland. All were operated on via the transnasal approach. Total resection was achieved in one patient and subtotal in two; in two cases we observed intact sellar dura and in one intact sellar floor. Histopathology showed immunoreactivity for synaptophysin in all cases and cytokeratin in two. The Ki-67 index was less than 2%. Immunohistochemical staining demonstrated growth hormone cells in all cases whereas prolactin and adrenocorticotropin in two. The patients were discharged home in good condition with no neurological deficits. Conclusions: Ectopic sphenoid sinus pituitary adenoma should always be considered in differential diagnosis of sphenoid sinus lesion in the elderly, especially in coexistence with empty sella or type 2 diabetes mellitus. Since ectopic sphenoid sinus pituitary adenoma is a benign lesion, surgical removal is an effective treatment. . SN - 1509-572X UR - https://www.unboundmedicine.com/medline/citation/28430293/Three_cases_of_ectopic_sphenoid_sinus_pituitary_adenoma_ DB - PRIME DP - Unbound Medicine ER -