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Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence.
Emerg Infect Dis 2017; 23(7):1110-1117EI

Abstract

In the Western Hemisphere, Zika virus is thought to be transmitted primarily by Aedes aegypti mosquitoes. To determine the extent to which Ae. albopictus mosquitoes from the United States are capable of transmitting Zika virus and the influence of virus dose, virus strain, and mosquito species on vector competence, we evaluated multiple doses of representative Zika virus strains in Ae. aegypti and Ae. albopictus mosquitoes. Virus preparation (fresh vs. frozen) significantly affected virus infectivity in mosquitoes. We calculated 50% infectious doses to be 6.1-7.5 log 10 PFU/mL; minimum infective dose was 4.2 log 10 PFU/mL. Ae. albopictus mosquitoes were more susceptible to infection than Ae. aegypti mosquitoes, but transmission efficiency was higher for Ae. aegypti mosquitoes, indicating a transmission barrier in Ae. albopictus mosquitoes. Results suggest that, although Zika virus transmission is relatively inefficient overall and dependent on virus strain and mosquito species, Ae. albopictus mosquitoes could become major vectors in the Americas.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

28430564

Citation

Ciota, Alexander T., et al. "Effects of Zika Virus Strain and Aedes Mosquito Species On Vector Competence." Emerging Infectious Diseases, vol. 23, no. 7, 2017, pp. 1110-1117.
Ciota AT, Bialosuknia SM, Zink SD, et al. Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence. Emerging Infect Dis. 2017;23(7):1110-1117.
Ciota, A. T., Bialosuknia, S. M., Zink, S. D., Brecher, M., Ehrbar, D. J., Morrissette, M. N., & Kramer, L. D. (2017). Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence. Emerging Infectious Diseases, 23(7), pp. 1110-1117. doi:10.3201/eid2307.161633.
Ciota AT, et al. Effects of Zika Virus Strain and Aedes Mosquito Species On Vector Competence. Emerging Infect Dis. 2017;23(7):1110-1117. PubMed PMID: 28430564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence. AU - Ciota,Alexander T, AU - Bialosuknia,Sean M, AU - Zink,Steven D, AU - Brecher,Matthew, AU - Ehrbar,Dylan J, AU - Morrissette,Madeline N, AU - Kramer,Laura D, Y1 - 2017/07/15/ PY - 2017/4/22/pubmed PY - 2018/3/27/medline PY - 2017/4/22/entrez KW - Aedes aegypti KW - Aedes albopictus KW - Zika virus KW - mosquitoes KW - vector competence KW - vector-borne infections KW - viruses SP - 1110 EP - 1117 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 23 IS - 7 N2 - In the Western Hemisphere, Zika virus is thought to be transmitted primarily by Aedes aegypti mosquitoes. To determine the extent to which Ae. albopictus mosquitoes from the United States are capable of transmitting Zika virus and the influence of virus dose, virus strain, and mosquito species on vector competence, we evaluated multiple doses of representative Zika virus strains in Ae. aegypti and Ae. albopictus mosquitoes. Virus preparation (fresh vs. frozen) significantly affected virus infectivity in mosquitoes. We calculated 50% infectious doses to be 6.1-7.5 log 10 PFU/mL; minimum infective dose was 4.2 log 10 PFU/mL. Ae. albopictus mosquitoes were more susceptible to infection than Ae. aegypti mosquitoes, but transmission efficiency was higher for Ae. aegypti mosquitoes, indicating a transmission barrier in Ae. albopictus mosquitoes. Results suggest that, although Zika virus transmission is relatively inefficient overall and dependent on virus strain and mosquito species, Ae. albopictus mosquitoes could become major vectors in the Americas. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/28430564/Effects_of_Zika_Virus_Strain_and_Aedes_Mosquito_Species_on_Vector_Competence_ L2 - https://dx.doi.org/10.3201/eid2307.161633 DB - PRIME DP - Unbound Medicine ER -