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Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence.

Abstract

In the Western Hemisphere, Zika virus is thought to be transmitted primarily by Aedes aegypti mosquitoes. To determine the extent to which Ae. albopictus mosquitoes from the United States are capable of transmitting Zika virus and the influence of virus dose, virus strain, and mosquito species on vector competence, we evaluated multiple doses of representative Zika virus strains in Ae. aegypti and Ae. albopictus mosquitoes. Virus preparation (fresh vs. frozen) significantly affected virus infectivity in mosquitoes. We calculated 50% infectious doses to be 6.1-7.5 log 10 PFU/mL; minimum infective dose was 4.2 log 10 PFU/mL. Ae. albopictus mosquitoes were more susceptible to infection than Ae. aegypti mosquitoes, but transmission efficiency was higher for Ae. aegypti mosquitoes, indicating a transmission barrier in Ae. albopictus mosquitoes. Results suggest that, although Zika virus transmission is relatively inefficient overall and dependent on virus strain and mosquito species, Ae. albopictus mosquitoes could become major vectors in the Americas.

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  • Authors

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    Source

    Emerging infectious diseases 23:7 2017 07 pg 1110-1117

    MeSH

    Aedes
    Animals
    Cercopithecus aethiops
    Host-Pathogen Interactions
    Insect Vectors
    Vero Cells
    Viral Load
    Virus Replication
    Zika Virus
    Zika Virus Infection

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28430564

    Citation

    Ciota, Alexander T., et al. "Effects of Zika Virus Strain and Aedes Mosquito Species On Vector Competence." Emerging Infectious Diseases, vol. 23, no. 7, 2017, pp. 1110-1117.
    Ciota AT, Bialosuknia SM, Zink SD, et al. Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence. Emerging Infect Dis. 2017;23(7):1110-1117.
    Ciota, A. T., Bialosuknia, S. M., Zink, S. D., Brecher, M., Ehrbar, D. J., Morrissette, M. N., & Kramer, L. D. (2017). Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence. Emerging Infectious Diseases, 23(7), pp. 1110-1117. doi:10.3201/eid2307.161633.
    Ciota AT, et al. Effects of Zika Virus Strain and Aedes Mosquito Species On Vector Competence. Emerging Infect Dis. 2017;23(7):1110-1117. PubMed PMID: 28430564.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence. AU - Ciota,Alexander T, AU - Bialosuknia,Sean M, AU - Zink,Steven D, AU - Brecher,Matthew, AU - Ehrbar,Dylan J, AU - Morrissette,Madeline N, AU - Kramer,Laura D, Y1 - 2017/07/15/ PY - 2017/4/22/pubmed PY - 2018/3/27/medline PY - 2017/4/22/entrez KW - Aedes aegypti KW - Aedes albopictus KW - Zika virus KW - mosquitoes KW - vector competence KW - vector-borne infections KW - viruses SP - 1110 EP - 1117 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 23 IS - 7 N2 - In the Western Hemisphere, Zika virus is thought to be transmitted primarily by Aedes aegypti mosquitoes. To determine the extent to which Ae. albopictus mosquitoes from the United States are capable of transmitting Zika virus and the influence of virus dose, virus strain, and mosquito species on vector competence, we evaluated multiple doses of representative Zika virus strains in Ae. aegypti and Ae. albopictus mosquitoes. Virus preparation (fresh vs. frozen) significantly affected virus infectivity in mosquitoes. We calculated 50% infectious doses to be 6.1-7.5 log 10 PFU/mL; minimum infective dose was 4.2 log 10 PFU/mL. Ae. albopictus mosquitoes were more susceptible to infection than Ae. aegypti mosquitoes, but transmission efficiency was higher for Ae. aegypti mosquitoes, indicating a transmission barrier in Ae. albopictus mosquitoes. Results suggest that, although Zika virus transmission is relatively inefficient overall and dependent on virus strain and mosquito species, Ae. albopictus mosquitoes could become major vectors in the Americas. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/28430564/Effects_of_Zika_Virus_Strain_and_Aedes_Mosquito_Species_on_Vector_Competence_ L2 - https://dx.doi.org/10.3201/eid2307.161633 DB - PRIME DP - Unbound Medicine ER -