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Exposure to an enriched environment facilitates motor recovery and prevents short-term memory impairment and reduction of striatal BDNF in a progressive pharmacological model of parkinsonism in mice.
Behav Brain Res 2017; 328:138-148BB

Abstract

Previous studies showed that the repeated administration with a low dose of reserpine (RES) induces a gradual appearance of motor signs and cognitive deficits compatible with parkinsonism in rodents. Environmental stimulation has neuroprotective effects in animal models of neurodegenerative damage, including acutely induced parkinsonism. We investigated the effects of exposure to an enriched environment (EE) on motor, cognitive and neuronal (levels of tyrosine hydroxylase, TH and brain derived neurotrophic factor, BDNF) deficits induced by a progressive model of Parkinson's disease (PD) in mice. Male mice were repeatedly treated with vehicle or 0.1mg/kg of RES (s.c) and kept under two housing conditions: standard environment (SE) and EE. In animals kept in SE, the treatment with RES induced deficits in motor function (catalepsy test, open field and oral movements), in novel object recognition (NOR) and plus-maze discriminative avoidance tasks. The environmental stimulation facilitated the recovery of motor deficits assessed by the catalepsy test after the end of treatment. Additionally, exposure to EE prevented the memory deficit in the NOR task. Treatment with RES induced a reduction in the number of TH positive cells in SNpc and VTA, which recovered 30days after the end of treatment. Finally, RES reduced the levels of BDNF in the striatum and the exposure to the EE prevented this effect. These results suggest that plastic brain changes induced by EE promote beneficial effects on the progression of neuronal impairment related to PD.

Authors+Show Affiliations

Memory Studies Laboratory, Department of Physiology, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address: clarissalcc@gmail.com.Laboratory of Behavioral and Evolutionary Neuroscience, Department of Bioscience, Universidade Federal de Sergipe, Itabaiana, SE, Brazil. Electronic address: joseronaldosantos@gmail.com.Memory Studies Laboratory, Department of Physiology, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address: anatildes.feitosa@gmail.com.Memory Studies Laboratory, Department of Physiology, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address: aline.ald16@gmail.com.Laboratory of Neurochemical Studies, Department of Physiology, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address: pontesalb@gmail.com.Laboratory of Neurochemical Studies, Department of Physiology, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address: jcs@cb.ufrn.br.Laboratory of Neuroscience and Bioprospecting of Natural Products, Department of Biosciences, Universidade Federal de São Paulo, Santos, SP, Brazil. Electronic address: alemrib@gmail.com.Memory Studies Laboratory, Department of Physiology, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Behavioral Neuroscience Laboratory, Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: reginahsilva@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28432010

Citation

Campêlo, Clarissa L C., et al. "Exposure to an Enriched Environment Facilitates Motor Recovery and Prevents Short-term Memory Impairment and Reduction of Striatal BDNF in a Progressive Pharmacological Model of Parkinsonism in Mice." Behavioural Brain Research, vol. 328, 2017, pp. 138-148.
Campêlo CLC, Santos JR, Silva AF, et al. Exposure to an enriched environment facilitates motor recovery and prevents short-term memory impairment and reduction of striatal BDNF in a progressive pharmacological model of parkinsonism in mice. Behav Brain Res. 2017;328:138-148.
Campêlo, C. L. C., Santos, J. R., Silva, A. F., Dierschnabel, A. L., Pontes, A., Cavalcante, J. S., ... Silva, R. H. (2017). Exposure to an enriched environment facilitates motor recovery and prevents short-term memory impairment and reduction of striatal BDNF in a progressive pharmacological model of parkinsonism in mice. Behavioural Brain Research, 328, pp. 138-148. doi:10.1016/j.bbr.2017.04.028.
Campêlo CLC, et al. Exposure to an Enriched Environment Facilitates Motor Recovery and Prevents Short-term Memory Impairment and Reduction of Striatal BDNF in a Progressive Pharmacological Model of Parkinsonism in Mice. Behav Brain Res. 2017 06 15;328:138-148. PubMed PMID: 28432010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to an enriched environment facilitates motor recovery and prevents short-term memory impairment and reduction of striatal BDNF in a progressive pharmacological model of parkinsonism in mice. AU - Campêlo,Clarissa L C, AU - Santos,José R, AU - Silva,Anatildes F, AU - Dierschnabel,Aline L, AU - Pontes,André, AU - Cavalcante,Jeferson S, AU - Ribeiro,Alessandra M, AU - Silva,Regina H, Y1 - 2017/04/18/ PY - 2016/05/30/received PY - 2017/04/11/revised PY - 2017/04/15/accepted PY - 2017/4/23/pubmed PY - 2018/2/8/medline PY - 2017/4/23/entrez KW - Animal model KW - BDNF KW - Enriched environment KW - Parkinson’s disease KW - Reserpine SP - 138 EP - 148 JF - Behavioural brain research JO - Behav. Brain Res. VL - 328 N2 - Previous studies showed that the repeated administration with a low dose of reserpine (RES) induces a gradual appearance of motor signs and cognitive deficits compatible with parkinsonism in rodents. Environmental stimulation has neuroprotective effects in animal models of neurodegenerative damage, including acutely induced parkinsonism. We investigated the effects of exposure to an enriched environment (EE) on motor, cognitive and neuronal (levels of tyrosine hydroxylase, TH and brain derived neurotrophic factor, BDNF) deficits induced by a progressive model of Parkinson's disease (PD) in mice. Male mice were repeatedly treated with vehicle or 0.1mg/kg of RES (s.c) and kept under two housing conditions: standard environment (SE) and EE. In animals kept in SE, the treatment with RES induced deficits in motor function (catalepsy test, open field and oral movements), in novel object recognition (NOR) and plus-maze discriminative avoidance tasks. The environmental stimulation facilitated the recovery of motor deficits assessed by the catalepsy test after the end of treatment. Additionally, exposure to EE prevented the memory deficit in the NOR task. Treatment with RES induced a reduction in the number of TH positive cells in SNpc and VTA, which recovered 30days after the end of treatment. Finally, RES reduced the levels of BDNF in the striatum and the exposure to the EE prevented this effect. These results suggest that plastic brain changes induced by EE promote beneficial effects on the progression of neuronal impairment related to PD. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/28432010/Exposure_to_an_enriched_environment_facilitates_motor_recovery_and_prevents_short_term_memory_impairment_and_reduction_of_striatal_BDNF_in_a_progressive_pharmacological_model_of_parkinsonism_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(17)30659-9 DB - PRIME DP - Unbound Medicine ER -