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Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial.
Drug Des Devel Ther. 2017; 11:1107-1113.DD

Abstract

BACKGROUND

Shivering is among the common troublesome complications of spinal anesthesia (SA), and causes discomfort and discontentment in parturients undergoing cesarean sections (CSs). The aim of this study was to investigate the effects of intrathecal dexmedetomidine in the prevention of shivering in those who underwent CS under SA.

SUBJECTS AND METHODS

Fifty parturients planned for elective CSs under SA were enrolled in this prospective, double-blinded, controlled study and randomly divided into two equal groups. Spinal block was achieved with 12.5 mg 0.5% heavy bupivacaine plus 5 μg dexmedetomidine (BD group) or 0.5 mL 0.9% normal saline (BN group). The incidence and intensity of shivering, peripheral and core body temperature, hemodynamic parameters, and adverse events was recorded.

RESULTS

The incidence of shivering was significantly higher in the BN group (52%) than the BD group (24%) (P=0.04). Likewise, the intensity of shivering was significantly higher in the BN group than the BD group (P=0.04). The incidence of adverse events, such as hypotension, nausea/vomiting, and bradycardia, was not significantly different between the two groups, although the grade of sedation was higher in the BD group than the BN group (P=0.004).

CONCLUSION

We conclude that intrathecal dexmedetomidine is effective in lowering the incidence and intensity of shivering in parturients undergoing CSs under SA without major adverse effects.

Authors+Show Affiliations

Department of Anesthesiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Anesthesiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28435222

Citation

Nasseri, Karim, et al. "Effects of Intrathecal Dexmedetomidine On Shivering After Spinal Anesthesia for Cesarean Section: a Double-blind Randomized Clinical Trial." Drug Design, Development and Therapy, vol. 11, 2017, pp. 1107-1113.
Nasseri K, Ghadami N, Nouri B. Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial. Drug Des Devel Ther. 2017;11:1107-1113.
Nasseri, K., Ghadami, N., & Nouri, B. (2017). Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial. Drug Design, Development and Therapy, 11, 1107-1113. https://doi.org/10.2147/DDDT.S131866
Nasseri K, Ghadami N, Nouri B. Effects of Intrathecal Dexmedetomidine On Shivering After Spinal Anesthesia for Cesarean Section: a Double-blind Randomized Clinical Trial. Drug Des Devel Ther. 2017;11:1107-1113. PubMed PMID: 28435222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial. AU - Nasseri,Karim, AU - Ghadami,Negin, AU - Nouri,Bijan, Y1 - 2017/04/03/ PY - 2017/4/25/entrez PY - 2017/4/25/pubmed PY - 2017/12/26/medline KW - bupivacaine KW - cesarean sections KW - dexmedetomidine KW - shivering KW - spinal anesthesia SP - 1107 EP - 1113 JF - Drug design, development and therapy JO - Drug Des Devel Ther VL - 11 N2 - BACKGROUND: Shivering is among the common troublesome complications of spinal anesthesia (SA), and causes discomfort and discontentment in parturients undergoing cesarean sections (CSs). The aim of this study was to investigate the effects of intrathecal dexmedetomidine in the prevention of shivering in those who underwent CS under SA. SUBJECTS AND METHODS: Fifty parturients planned for elective CSs under SA were enrolled in this prospective, double-blinded, controlled study and randomly divided into two equal groups. Spinal block was achieved with 12.5 mg 0.5% heavy bupivacaine plus 5 μg dexmedetomidine (BD group) or 0.5 mL 0.9% normal saline (BN group). The incidence and intensity of shivering, peripheral and core body temperature, hemodynamic parameters, and adverse events was recorded. RESULTS: The incidence of shivering was significantly higher in the BN group (52%) than the BD group (24%) (P=0.04). Likewise, the intensity of shivering was significantly higher in the BN group than the BD group (P=0.04). The incidence of adverse events, such as hypotension, nausea/vomiting, and bradycardia, was not significantly different between the two groups, although the grade of sedation was higher in the BD group than the BN group (P=0.004). CONCLUSION: We conclude that intrathecal dexmedetomidine is effective in lowering the incidence and intensity of shivering in parturients undergoing CSs under SA without major adverse effects. SN - 1177-8881 UR - https://www.unboundmedicine.com/medline/citation/28435222/Effects_of_intrathecal_dexmedetomidine_on_shivering_after_spinal_anesthesia_for_cesarean_section:_a_double_blind_randomized_clinical_trial_ L2 - https://dx.doi.org/10.2147/DDDT.S131866 DB - PRIME DP - Unbound Medicine ER -