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C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells.
Phytochemistry. 2017 Aug; 140:1-15.P

Abstract

Twenty-three undescribed previously C21 steroidal glycosides, named saccatols D-K and cynsaccatols I-W, together with six known analogs were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Apocynaceae). Their structures were elucidated by a variety of spectroscopic techniques, as well as HRESIMS and GC method. All isolated compounds were tested their neuroprotective effects on the model of H2O2-induced damage to PC12 cells. Except saccatols D-F, J, cynsaccatol V and wilfoside A, other twenty-three isolates produced significantly activities against H2O2-induced cell damage (P < 0.001). Furthermore, cynsaccatols I, N, O and S can obvious inhibition of damaged PC12 cell apoptosis at their dosages of 1 μM by Annexin V-FITC/PI double staining assay with flow cytometry.

Authors+Show Affiliations

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. Electronic address: mizhangkmust@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28437621

Citation

Qian, Xicheng, et al. "C21 Steroidal Glycosides From Cynanchum Auriculatum and Their Neuroprotective Effects Against H2O2-induced Damage in PC12 Cells." Phytochemistry, vol. 140, 2017, pp. 1-15.
Qian X, Li B, Li P, et al. C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells. Phytochemistry. 2017;140:1-15.
Qian, X., Li, B., Li, P., Wang, D., Dai, W., & Zhang, M. (2017). C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells. Phytochemistry, 140, 1-15. https://doi.org/10.1016/j.phytochem.2017.04.014
Qian X, et al. C21 Steroidal Glycosides From Cynanchum Auriculatum and Their Neuroprotective Effects Against H2O2-induced Damage in PC12 Cells. Phytochemistry. 2017;140:1-15. PubMed PMID: 28437621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells. AU - Qian,Xicheng, AU - Li,Baocai, AU - Li,Peng, AU - Wang,Dong, AU - Dai,Weifeng, AU - Zhang,Mi, Y1 - 2017/04/21/ PY - 2017/01/03/received PY - 2017/04/13/revised PY - 2017/04/18/accepted PY - 2017/4/25/pubmed PY - 2017/7/18/medline PY - 2017/4/25/entrez KW - Apocynaceae KW - Apoptosis KW - C(21) steroidal glycosides KW - Cynanchum auriculatum KW - Neuroprotecton KW - PC12 SP - 1 EP - 15 JF - Phytochemistry JO - Phytochemistry VL - 140 N2 - Twenty-three undescribed previously C21 steroidal glycosides, named saccatols D-K and cynsaccatols I-W, together with six known analogs were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Apocynaceae). Their structures were elucidated by a variety of spectroscopic techniques, as well as HRESIMS and GC method. All isolated compounds were tested their neuroprotective effects on the model of H2O2-induced damage to PC12 cells. Except saccatols D-F, J, cynsaccatol V and wilfoside A, other twenty-three isolates produced significantly activities against H2O2-induced cell damage (P < 0.001). Furthermore, cynsaccatols I, N, O and S can obvious inhibition of damaged PC12 cell apoptosis at their dosages of 1 μM by Annexin V-FITC/PI double staining assay with flow cytometry. SN - 1873-3700 UR - https://www.unboundmedicine.com/medline/citation/28437621/C21_steroidal_glycosides_from_Cynanchum_auriculatum_and_their_neuroprotective_effects_against_H2O2_induced_damage_in_PC12_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(17)30163-2 DB - PRIME DP - Unbound Medicine ER -