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Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case.
Clin Neuropathol 2017 Jul/Aug; 36(4):164-170CN

Abstract

A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses. A BRAF mutation was found in the tumor. Although extremely rare, both benign and malignant glomus tumors may present in large peripheral nerves and should therefore be considered in the differential diagnosis. .

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28438258

Citation

Dahlin, Lars B., et al. "Intraneural Glomus Tumor of "uncertain Malignant Potential" and With BRAF Mutation in the Median Nerve - an Unusual Case." Clinical Neuropathology, vol. 36, no. 4, 2017, pp. 164-170.
Dahlin LB, Scherman P, Besjakov J, et al. Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. Clin Neuropathol. 2017;36(4):164-170.
Dahlin, L. B., Scherman, P., Besjakov, J., Lindberg, E., Solomon, D. A., Horvai, A. E., & Perry, A. (2017). Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. Clinical Neuropathology, 36(4), pp. 164-170. doi:10.5414/NP300989.
Dahlin LB, et al. Intraneural Glomus Tumor of "uncertain Malignant Potential" and With BRAF Mutation in the Median Nerve - an Unusual Case. Clin Neuropathol. 2017;36(4):164-170. PubMed PMID: 28438258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. AU - Dahlin,Lars B, AU - Scherman,Peter, AU - Besjakov,Jack, AU - Lindberg,Eva, AU - Solomon,David A, AU - Horvai,Andrew E, AU - Perry,Arie, PY - 2017/06/29/accepted PY - 2017/4/26/pubmed PY - 2018/8/25/medline PY - 2017/4/26/entrez SP - 164 EP - 170 JF - Clinical neuropathology JO - Clin. Neuropathol. VL - 36 IS - 4 N2 - A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses. A BRAF mutation was found in the tumor. Although extremely rare, both benign and malignant glomus tumors may present in large peripheral nerves and should therefore be considered in the differential diagnosis. . SN - 0722-5091 UR - https://www.unboundmedicine.com/medline/citation/28438258/Intraneural_glomus_tumor_of_"uncertain_malignant_potential"_and_with_BRAF_mutation_in_the_median_nerve___an_unusual_case_ L2 - https://www.dustri.com/nc/journals-in-english?artId=15487 DB - PRIME DP - Unbound Medicine ER -