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Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios.
Biochim Biophys Acta. 1988 Oct 14; 962(3):337-44.BB

Abstract

Rats were fed diets containing a high level of saturated fatty acids (hydrogenated beef tallow) versus a high level of linoleic acid (safflower oil) at both low and high levels of fish oil containing 7.5% (w/w) eicosapentaenoic and 2.5% (w/w) docosahexaenoic acids for a period of 28 days. The effect of feeding these diets on the cholesterol content and fatty acid composition of serum and liver lipids was examined. Feeding diets high in fish oil with safflower oil decreased the cholesterol content of rat serum, whereas feeding fish oil had no significant effect on the cholesterol content of serum when fed in combination with saturated fatty acids. The serum cholesterol level was higher in animals fed safflower oil compared to animals fed saturated fat without fish oil. Consumption of fish oil lowered the cholesterol content of liver tissue regardless of the dietary fat fed. Feeding diets containing fish oil reduced the arachidonic acid content of rat serum and liver lipid fractions, the decrease being more pronounced when fish oil was fed in combination with hydrogenated beef tallow than with safflower oil. These results suggest that dietary n-3 fatty acids of fish oil interact with dietary linoleic acid and saturated fatty acids differently to modulate enzymes of cholesterol and fatty acid metabolism.

Authors+Show Affiliations

Department of Foods and Nutrition, Faculty of Home Economics, University of Alberta, Edmonton, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2844278

Citation

Garg, M L., et al. "Fish Oil Reduces Cholesterol and Arachidonic Acid Content More Efficiently in Rats Fed Diets Containing Low Linoleic Acid to Saturated Fatty Acid Ratios." Biochimica Et Biophysica Acta, vol. 962, no. 3, 1988, pp. 337-44.
Garg ML, Wierzbicki AA, Thomson AB, et al. Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios. Biochim Biophys Acta. 1988;962(3):337-44.
Garg, M. L., Wierzbicki, A. A., Thomson, A. B., & Clandinin, M. T. (1988). Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios. Biochimica Et Biophysica Acta, 962(3), 337-44.
Garg ML, et al. Fish Oil Reduces Cholesterol and Arachidonic Acid Content More Efficiently in Rats Fed Diets Containing Low Linoleic Acid to Saturated Fatty Acid Ratios. Biochim Biophys Acta. 1988 Oct 14;962(3):337-44. PubMed PMID: 2844278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios. AU - Garg,M L, AU - Wierzbicki,A A, AU - Thomson,A B, AU - Clandinin,M T, PY - 1988/10/14/pubmed PY - 1988/10/14/medline PY - 1988/10/14/entrez SP - 337 EP - 44 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 962 IS - 3 N2 - Rats were fed diets containing a high level of saturated fatty acids (hydrogenated beef tallow) versus a high level of linoleic acid (safflower oil) at both low and high levels of fish oil containing 7.5% (w/w) eicosapentaenoic and 2.5% (w/w) docosahexaenoic acids for a period of 28 days. The effect of feeding these diets on the cholesterol content and fatty acid composition of serum and liver lipids was examined. Feeding diets high in fish oil with safflower oil decreased the cholesterol content of rat serum, whereas feeding fish oil had no significant effect on the cholesterol content of serum when fed in combination with saturated fatty acids. The serum cholesterol level was higher in animals fed safflower oil compared to animals fed saturated fat without fish oil. Consumption of fish oil lowered the cholesterol content of liver tissue regardless of the dietary fat fed. Feeding diets containing fish oil reduced the arachidonic acid content of rat serum and liver lipid fractions, the decrease being more pronounced when fish oil was fed in combination with hydrogenated beef tallow than with safflower oil. These results suggest that dietary n-3 fatty acids of fish oil interact with dietary linoleic acid and saturated fatty acids differently to modulate enzymes of cholesterol and fatty acid metabolism. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/2844278/Fish_oil_reduces_cholesterol_and_arachidonic_acid_content_more_efficiently_in_rats_fed_diets_containing_low_linoleic_acid_to_saturated_fatty_acid_ratios_ DB - PRIME DP - Unbound Medicine ER -