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Prevalence and risk factors for diabetic retinopathy in 17 152 patients from the island of Funen, Denmark.
Acta Ophthalmol. 2017 Dec; 95(8):778-786.AO

Abstract

PURPOSE

This study aims to estimate the prevalence and risk factors of diabetic retinopathy (DR) in patients enrolled in a large Danish quality-assuring database for diabetes: the Funen Diabetes Database (FDDB).

METHODS

All patients with type 1 (T1DM) and type 2 DM (T2DM) diabetes mellitus (DM) were included in a cross-sectional study. The level of DR per patient was determined based on the eye with highest level of DR. All ocular and non-ocular data were extracted at the latest examination that corresponded to the most recent DR-grading data.

RESULTS

Data from 17 152 patients were analysed; 83.1% had T2DM. Prevalence of DR was 23.8% (T1DM: 54.3%, T2DM: 21.2%). T1/T2DM patients were statistically significantly different regarding age, duration of diabetes, BMI, systolic blood pressure (BP), cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, s-creatinine and u-albumin (p < 0.001 for all). Increasing level of DR showed statistically significant association with age, duration of diabetes, systolic BP, HbA1c, s-creatinine and u-albumine with increasing level of DR (all are p < 0.001) both T1DM/T2DM patients.

CONCLUSION

The patients in FDDB had good systemic control with median values of BP, serum lipids, cholesterol and HbA1c all close to or below national guidelines at the time of data extraction, but still a high level of DR was found in this cohort. DR was more common in patients with T1DM than T2DM, but as T2DM patients are more numerous, their level of DR despite acceptable control is still concerning. Most important associated factors for higher levels of DR were age, duration of diabetes, HbA1c, s-creatinine and u-albumine.

Authors+Show Affiliations

NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK. Research Unit of Ophthalmology, Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark. Department of Ophthalmology, Odense University Hospital, Odense, Denmark.Department of Endocrinology, Odense University Hospital, Odense, Denmark.Research Unit of Ophthalmology, Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark. Department of Ophthalmology, Odense University Hospital, Odense, Denmark.NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK. Research Unit of Ophthalmology, Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark. Queen's University Belfast, Belfast, UK.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28444837

Citation

Larsen, Morten B., et al. "Prevalence and Risk Factors for Diabetic Retinopathy in 17 152 Patients From the Island of Funen, Denmark." Acta Ophthalmologica, vol. 95, no. 8, 2017, pp. 778-786.
Larsen MB, Henriksen JE, Grauslund J, et al. Prevalence and risk factors for diabetic retinopathy in 17 152 patients from the island of Funen, Denmark. Acta Ophthalmol. 2017;95(8):778-786.
Larsen, M. B., Henriksen, J. E., Grauslund, J., & Peto, T. (2017). Prevalence and risk factors for diabetic retinopathy in 17 152 patients from the island of Funen, Denmark. Acta Ophthalmologica, 95(8), 778-786. https://doi.org/10.1111/aos.13449
Larsen MB, et al. Prevalence and Risk Factors for Diabetic Retinopathy in 17 152 Patients From the Island of Funen, Denmark. Acta Ophthalmol. 2017;95(8):778-786. PubMed PMID: 28444837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and risk factors for diabetic retinopathy in 17 152 patients from the island of Funen, Denmark. AU - Larsen,Morten B, AU - Henriksen,Jan Erik, AU - Grauslund,Jakob, AU - Peto,Tunde, Y1 - 2017/04/26/ PY - 2016/02/09/received PY - 2017/02/28/accepted PY - 2017/4/27/pubmed PY - 2018/1/3/medline PY - 2017/4/27/entrez KW - Denmark KW - Europe KW - associated factor KW - diabetes KW - diabetic retinopathy KW - prevalence KW - risk factor SP - 778 EP - 786 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 95 IS - 8 N2 - PURPOSE: This study aims to estimate the prevalence and risk factors of diabetic retinopathy (DR) in patients enrolled in a large Danish quality-assuring database for diabetes: the Funen Diabetes Database (FDDB). METHODS: All patients with type 1 (T1DM) and type 2 DM (T2DM) diabetes mellitus (DM) were included in a cross-sectional study. The level of DR per patient was determined based on the eye with highest level of DR. All ocular and non-ocular data were extracted at the latest examination that corresponded to the most recent DR-grading data. RESULTS: Data from 17 152 patients were analysed; 83.1% had T2DM. Prevalence of DR was 23.8% (T1DM: 54.3%, T2DM: 21.2%). T1/T2DM patients were statistically significantly different regarding age, duration of diabetes, BMI, systolic blood pressure (BP), cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, s-creatinine and u-albumin (p < 0.001 for all). Increasing level of DR showed statistically significant association with age, duration of diabetes, systolic BP, HbA1c, s-creatinine and u-albumine with increasing level of DR (all are p < 0.001) both T1DM/T2DM patients. CONCLUSION: The patients in FDDB had good systemic control with median values of BP, serum lipids, cholesterol and HbA1c all close to or below national guidelines at the time of data extraction, but still a high level of DR was found in this cohort. DR was more common in patients with T1DM than T2DM, but as T2DM patients are more numerous, their level of DR despite acceptable control is still concerning. Most important associated factors for higher levels of DR were age, duration of diabetes, HbA1c, s-creatinine and u-albumine. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/28444837/Prevalence_and_risk_factors_for_diabetic_retinopathy_in_17_152_patients_from_the_island_of_Funen_Denmark_ DB - PRIME DP - Unbound Medicine ER -