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Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies.

Abstract

A large number of epidemiological studies have provided conflicting results about the relationship between tea consumption and ovarian cancer. This study aimed to clarify the association between tea consumption and ovarian cancer. A literature search of the MEDICINE, Scopus, PubMed, and Web of Science databases was performed in April 2016. A total of 18 (11 case-control and 7 cohort) studies, representing data for 701,857 female subjects including 8,683 ovarian cancer cases, were included in the meta-analysis. A random-effects meta-analysis was used to compute the pooled relative risks (RR), meta regression, and publication bias, and heterogeneity analyses were performed for the included trials. We found that tea consumption had a significant protective effect against ovarian cancer (relative risk [RR] = 0.86; 95% confidence interval [CI]: 0.76, 0.96). The relationship was confirmed particularly after adjusting for family history of cancer (RR = 0.85; 95% CI: 0.72, 0.97), menopause status (RR = 0.85; 95% CI: 0.72, 0.98), education (RR = 0.82; 95% CI: 0.68, 0.96), BMI (RR = 0.85; 95% CI: 0.70, 1.00) , smoking (RR = 0.83; 95% CI: 0.72, 0.93) and Jadad score of 3 (RR = 0.76; 95% CI: 0.56, 0.95) and 5 (RR = 0.74; 95% CI: 0.59, 0.89). The Begg's and Egger's tests (all P > 0.01) showed no evidence of publication bias. In conclusion, our meta-analysis showed an inverse association between tea consumption and ovarian cancer risk. High quality cohort-clinical trials should be conducted on different tea types and their relationship with ovarian cancer.

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  • Authors+Show Affiliations

    ,

    Obstetrics and Gynecology Department, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, PR China.

    ,

    Obstetrics and Gynecology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University Zhejiang Provincial Hospital of TCM, Hangzhou, Zhejiang 310016, PR China.

    ,

    Department of Obstetrics and Gynecology, Central Hospital of Wenzhou, Luchengqu, Wenzhou, Zhejiang 325000, PR China.

    Obstetrics and Gynecology Department, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, PR China.

    Source

    Oncotarget 8:23 2017 Jun 06 pg 37796-37806

    MeSH

    Epidemiologic Studies
    Female
    Humans
    Ovarian Neoplasms
    Risk Factors
    Tea

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    28445129

    Citation

    Zhan, Xin, et al. "Tea Consumption and the Risk of Ovarian Cancer: a Meta-analysis of Epidemiological Studies." Oncotarget, vol. 8, no. 23, 2017, pp. 37796-37806.
    Zhan X, Wang J, Pan S, et al. Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies. Oncotarget. 2017;8(23):37796-37806.
    Zhan, X., Wang, J., Pan, S., & Lu, C. (2017). Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies. Oncotarget, 8(23), pp. 37796-37806. doi:10.18632/oncotarget.16890.
    Zhan X, et al. Tea Consumption and the Risk of Ovarian Cancer: a Meta-analysis of Epidemiological Studies. Oncotarget. 2017 Jun 6;8(23):37796-37806. PubMed PMID: 28445129.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies. AU - Zhan,Xin, AU - Wang,Jie, AU - Pan,Shufen, AU - Lu,Caijuan, PY - 2016/11/08/received PY - 2017/03/27/accepted PY - 2017/4/27/pubmed PY - 2018/4/25/medline PY - 2017/4/27/entrez KW - meta-analysis KW - ovarian cancer KW - tea SP - 37796 EP - 37806 JF - Oncotarget JO - Oncotarget VL - 8 IS - 23 N2 - A large number of epidemiological studies have provided conflicting results about the relationship between tea consumption and ovarian cancer. This study aimed to clarify the association between tea consumption and ovarian cancer. A literature search of the MEDICINE, Scopus, PubMed, and Web of Science databases was performed in April 2016. A total of 18 (11 case-control and 7 cohort) studies, representing data for 701,857 female subjects including 8,683 ovarian cancer cases, were included in the meta-analysis. A random-effects meta-analysis was used to compute the pooled relative risks (RR), meta regression, and publication bias, and heterogeneity analyses were performed for the included trials. We found that tea consumption had a significant protective effect against ovarian cancer (relative risk [RR] = 0.86; 95% confidence interval [CI]: 0.76, 0.96). The relationship was confirmed particularly after adjusting for family history of cancer (RR = 0.85; 95% CI: 0.72, 0.97), menopause status (RR = 0.85; 95% CI: 0.72, 0.98), education (RR = 0.82; 95% CI: 0.68, 0.96), BMI (RR = 0.85; 95% CI: 0.70, 1.00) , smoking (RR = 0.83; 95% CI: 0.72, 0.93) and Jadad score of 3 (RR = 0.76; 95% CI: 0.56, 0.95) and 5 (RR = 0.74; 95% CI: 0.59, 0.89). The Begg's and Egger's tests (all P > 0.01) showed no evidence of publication bias. In conclusion, our meta-analysis showed an inverse association between tea consumption and ovarian cancer risk. High quality cohort-clinical trials should be conducted on different tea types and their relationship with ovarian cancer. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/28445129/Tea_consumption_and_the_risk_of_ovarian_cancer:_A_meta_analysis_of_epidemiological_studies_ L2 - http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=16890 DB - PRIME DP - Unbound Medicine ER -