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POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH CENTRAL SEROUS CHORIORETINOPATHY: Pachychoroid Spectrum of Diseases.
Retina. 2018 Jun; 38(6):1195-1204.R

Abstract

PURPOSE

To study multimodal imaging features of polypoidal choroidal vasculopathy (PCV) associated with central serous chorioretinopathy (CSC) in the same eye.

METHODS

A retrospective observational study of cases of suspected PCV which underwent indocyanine green angiography, fundus fluorescein angiography and optical coherence tomography was done, to look for simultaneous typical CSC-like active leak in the same eye. The relevant history, best-corrected visual acuity, optical coherence tomography, fundus fluorescein angiography, and indocyanine green angiography findings were analyzed.

RESULTS

From 226 patients reviewed, 195 patients had PCV from which 6 eyes (3.07%) with features of PCV associated with typical CSC-like active leak in the same eye were identified; 3 men and 3 women with a mean age of 62.6 years. Optical coherence tomography showed notched pigment epithelial detachment in two and irregular peaked pigment epithelial detachment in four cases with subretinal fluid and/or subretinal haemorrhage over a thick choroid with dilated outer choroidal vessels. Fundus fluorescein angiography showed stippled hyperfluorescence at polyp area and a separate typical CSC-like active leak-Inkblot in three and Smokestack in three cases. On indocyanine green angiography, multiple polyps were noted with choroidal hyperpermeability in late phase at the site of CSC leak.

CONCLUSION

The coexistence of PCV with typical CSC-like active leaks and a thick choroid in the same eye simultaneously provides strong evidence that these diseases have an association and support the hypothesis that these conditions may originate from predisposed thick choroid.

Authors+Show Affiliations

Department of Vitreoretina services, Aravind Eye Hospital, Coimbatore, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Observational Study

Language

eng

PubMed ID

28445211

Citation

Manayath, George J., et al. "POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH CENTRAL SEROUS CHORIORETINOPATHY: Pachychoroid Spectrum of Diseases." Retina (Philadelphia, Pa.), vol. 38, no. 6, 2018, pp. 1195-1204.
Manayath GJ, Shah VS, Saravanan VR, et al. POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH CENTRAL SEROUS CHORIORETINOPATHY: Pachychoroid Spectrum of Diseases. Retina (Philadelphia, Pa). 2018;38(6):1195-1204.
Manayath, G. J., Shah, V. S., Saravanan, V. R., & Narendran, V. (2018). POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH CENTRAL SEROUS CHORIORETINOPATHY: Pachychoroid Spectrum of Diseases. Retina (Philadelphia, Pa.), 38(6), 1195-1204. https://doi.org/10.1097/IAE.0000000000001665
Manayath GJ, et al. POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH CENTRAL SEROUS CHORIORETINOPATHY: Pachychoroid Spectrum of Diseases. Retina (Philadelphia, Pa). 2018;38(6):1195-1204. PubMed PMID: 28445211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH CENTRAL SEROUS CHORIORETINOPATHY: Pachychoroid Spectrum of Diseases. AU - Manayath,George J, AU - Shah,Vanee Sheth, AU - Saravanan,Veerappan R, AU - Narendran,Venkatapathy, PY - 2017/4/27/pubmed PY - 2018/7/7/medline PY - 2017/4/27/entrez SP - 1195 EP - 1204 JF - Retina (Philadelphia, Pa.) JO - Retina (Philadelphia, Pa.) VL - 38 IS - 6 N2 - PURPOSE: To study multimodal imaging features of polypoidal choroidal vasculopathy (PCV) associated with central serous chorioretinopathy (CSC) in the same eye. METHODS: A retrospective observational study of cases of suspected PCV which underwent indocyanine green angiography, fundus fluorescein angiography and optical coherence tomography was done, to look for simultaneous typical CSC-like active leak in the same eye. The relevant history, best-corrected visual acuity, optical coherence tomography, fundus fluorescein angiography, and indocyanine green angiography findings were analyzed. RESULTS: From 226 patients reviewed, 195 patients had PCV from which 6 eyes (3.07%) with features of PCV associated with typical CSC-like active leak in the same eye were identified; 3 men and 3 women with a mean age of 62.6 years. Optical coherence tomography showed notched pigment epithelial detachment in two and irregular peaked pigment epithelial detachment in four cases with subretinal fluid and/or subretinal haemorrhage over a thick choroid with dilated outer choroidal vessels. Fundus fluorescein angiography showed stippled hyperfluorescence at polyp area and a separate typical CSC-like active leak-Inkblot in three and Smokestack in three cases. On indocyanine green angiography, multiple polyps were noted with choroidal hyperpermeability in late phase at the site of CSC leak. CONCLUSION: The coexistence of PCV with typical CSC-like active leaks and a thick choroid in the same eye simultaneously provides strong evidence that these diseases have an association and support the hypothesis that these conditions may originate from predisposed thick choroid. SN - 1539-2864 UR - https://www.unboundmedicine.com/medline/citation/28445211/POLYPOIDAL_CHOROIDAL_VASCULOPATHY_ASSOCIATED_WITH_CENTRAL_SEROUS_CHORIORETINOPATHY:_Pachychoroid_Spectrum_of_Diseases_ L2 - http://dx.doi.org/10.1097/IAE.0000000000001665 DB - PRIME DP - Unbound Medicine ER -