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Revisiting propafenone toxicity.
BMJ Case Rep 2017; 2017BC

Abstract

Propafenone is a Vaughan Williams class 1c antiarrhythmic medication widely used for treatment of arrhythmias. Although the long-term safety of propafenone use has not been established, it is commonly used for treatment of atrial fibrillation in patients with no structural heart disease. Propafenone is well known as pill-in-the-pocket treatment for its effect in terminating paroxysmal episodes of atrial fibrillation. Herein, we discuss an unusual adverse reaction to propafenone in a patient who presented with symptomatic bradycardia and hypotension. The aim of this article is to increase physician awareness for propafenone toxicity and its management, with a focused literature review on propafenone pharmacotherapy.

Authors+Show Affiliations

Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA.Department of Cardiovascular Diseases, Mayo Clinic Florida, Jacksonville, Florida, USA.Department of Cardiovascular Diseases, Mayo Clinic Florida, Jacksonville, Florida, USA.Department of Cardiovascular Diseases, Mayo Clinic Florida, Jacksonville, Florida, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28446489

Citation

Alsaad, Ali A., et al. "Revisiting Propafenone Toxicity." BMJ Case Reports, vol. 2017, 2017.
Alsaad AA, Ortiz Gonzalez Y, Austin CO, et al. Revisiting propafenone toxicity. BMJ Case Rep. 2017;2017.
Alsaad, A. A., Ortiz Gonzalez, Y., Austin, C. O., & Kusumoto, F. (2017). Revisiting propafenone toxicity. BMJ Case Reports, 2017, doi:10.1136/bcr-2017-219270.
Alsaad AA, et al. Revisiting Propafenone Toxicity. BMJ Case Rep. 2017 Apr 26;2017 PubMed PMID: 28446489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Revisiting propafenone toxicity. AU - Alsaad,Ali A, AU - Ortiz Gonzalez,Yahaira, AU - Austin,Christopher O, AU - Kusumoto,Fred, Y1 - 2017/04/26/ PY - 2017/4/28/entrez PY - 2017/4/28/pubmed PY - 2017/6/14/medline KW - Cardiovascular medicine KW - Drug interactions KW - Pacing and electrophysiology JF - BMJ case reports JO - BMJ Case Rep VL - 2017 N2 - Propafenone is a Vaughan Williams class 1c antiarrhythmic medication widely used for treatment of arrhythmias. Although the long-term safety of propafenone use has not been established, it is commonly used for treatment of atrial fibrillation in patients with no structural heart disease. Propafenone is well known as pill-in-the-pocket treatment for its effect in terminating paroxysmal episodes of atrial fibrillation. Herein, we discuss an unusual adverse reaction to propafenone in a patient who presented with symptomatic bradycardia and hypotension. The aim of this article is to increase physician awareness for propafenone toxicity and its management, with a focused literature review on propafenone pharmacotherapy. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/28446489/Revisiting_propafenone_toxicity_ L2 - http://casereports.bmj.com/cgi/pmidlookup?view=long&pmid=28446489 DB - PRIME DP - Unbound Medicine ER -