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Tissue Distribution of the MERS-Coronavirus Receptor in Bats.
Sci Rep. 2017 04 26; 7(1):1193.SR

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs. In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (Epomophorus gambianus and Rousettus aegyptiacus) and two insectivorous bat species (Pipistrellus pipistrellus and Eptesicus serotinus). In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and humans. In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent. The preferential expression of DPP4 in the intestinal tract of insectivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route. Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route.

Authors+Show Affiliations

Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Institute of Zoology, Zoological Society of London, Regents Park, London, United Kingdom.Institute for Novel and Emerging Infectious Diseases, Friedrich Loeffler Institute, Greifswald, Mecklenburg-Vorpommern, Germany.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands. b.haagmans@erasmusmc.nl.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28446791

Citation

Widagdo, W, et al. "Tissue Distribution of the MERS-Coronavirus Receptor in Bats." Scientific Reports, vol. 7, no. 1, 2017, p. 1193.
Widagdo W, Begeman L, Schipper D, et al. Tissue Distribution of the MERS-Coronavirus Receptor in Bats. Sci Rep. 2017;7(1):1193.
Widagdo, W., Begeman, L., Schipper, D., Run, P. R. V., Cunningham, A. A., Kley, N., Reusken, C. B., Haagmans, B. L., & van den Brand, J. M. A. (2017). Tissue Distribution of the MERS-Coronavirus Receptor in Bats. Scientific Reports, 7(1), 1193. https://doi.org/10.1038/s41598-017-01290-6
Widagdo W, et al. Tissue Distribution of the MERS-Coronavirus Receptor in Bats. Sci Rep. 2017 04 26;7(1):1193. PubMed PMID: 28446791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue Distribution of the MERS-Coronavirus Receptor in Bats. AU - Widagdo,W, AU - Begeman,Lineke, AU - Schipper,Debby, AU - Run,Peter R van, AU - Cunningham,Andrew A, AU - Kley,Nils, AU - Reusken,Chantal B, AU - Haagmans,Bart L, AU - van den Brand,Judith M A, Y1 - 2017/04/26/ PY - 2017/01/26/received PY - 2017/03/27/accepted PY - 2017/4/28/entrez PY - 2017/4/28/pubmed PY - 2018/9/7/medline SP - 1193 EP - 1193 JF - Scientific reports JO - Sci Rep VL - 7 IS - 1 N2 - Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs. In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (Epomophorus gambianus and Rousettus aegyptiacus) and two insectivorous bat species (Pipistrellus pipistrellus and Eptesicus serotinus). In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and humans. In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent. The preferential expression of DPP4 in the intestinal tract of insectivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route. Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28446791/Tissue_Distribution_of_the_MERS_Coronavirus_Receptor_in_Bats_ L2 - https://doi.org/10.1038/s41598-017-01290-6 DB - PRIME DP - Unbound Medicine ER -