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The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects.
J Allergy Clin Immunol. 1988 Oct; 82(4):654-60.JA

Abstract

Eight subjects with asthma inhaled on separate occasions leukotriene E4 (LTE4) (6.1 nmol, geometric mean), methacholine, and diluent, which produced an average 41.0%, 37.0%, and 3.3% decrease in specific airway conductance (SGaw), respectively. When the SGaw had recovered to baseline levels at 60 minutes after challenge, the provocative dose of inhaled histamine that produced a 35% decrease in SGaw (PD35) was determined. The histamine PD35 observed after inhalation of LTE4 was 0.46 mumol, and this was significantly less than the histamine PD35 observed after inhalation of methacholine (0.88 mumol; p less than 10(-4) and diluent (0.97 mumol; p less than 10(-5). Histamine responsiveness was also enhanced by a fiftyfold lower dose of LTE4 (p = 0.005), and the enhancement was less than that elicited by the higher dose of LTE4 in the same individuals (p = 0.02). The changes in histamine PD35 during a 1-week period after LTE4 and methacholine challenges were compared in four subjects with asthma. There was a time-dependent enhancement in histamine responsiveness that reached a maximal of 3.5-fold at 7 hours after LTE4. The enhancement had disappeared by 1 week. Similar changes were not observed after methacholine challenge, which elicited the same degree of bronchoconstriction as LTE4. Inhalation of LTE4 in five normal subjects that produced a mean 37.6% decrease in SGaw did not change histamine responsiveness for up to 7 hours. These findings suggest that LTE4 may play a role in the perpetuation of nonspecific airway hyperresponsiveness in bronchial asthma.

Authors+Show Affiliations

Department of Allergy and Allied Respiratory Disorders, United Medical School, Guy's Hospital, London, England.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2844876

Citation

Arm, J P., et al. "The Effects of Inhaled Leukotriene E4 On the Airway Responsiveness to Histamine in Subjects With Asthma and Normal Subjects." The Journal of Allergy and Clinical Immunology, vol. 82, no. 4, 1988, pp. 654-60.
Arm JP, Spur BW, Lee TH. The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects. J Allergy Clin Immunol. 1988;82(4):654-60.
Arm, J. P., Spur, B. W., & Lee, T. H. (1988). The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects. The Journal of Allergy and Clinical Immunology, 82(4), 654-60.
Arm JP, Spur BW, Lee TH. The Effects of Inhaled Leukotriene E4 On the Airway Responsiveness to Histamine in Subjects With Asthma and Normal Subjects. J Allergy Clin Immunol. 1988;82(4):654-60. PubMed PMID: 2844876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects. AU - Arm,J P, AU - Spur,B W, AU - Lee,T H, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 654 EP - 60 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 82 IS - 4 N2 - Eight subjects with asthma inhaled on separate occasions leukotriene E4 (LTE4) (6.1 nmol, geometric mean), methacholine, and diluent, which produced an average 41.0%, 37.0%, and 3.3% decrease in specific airway conductance (SGaw), respectively. When the SGaw had recovered to baseline levels at 60 minutes after challenge, the provocative dose of inhaled histamine that produced a 35% decrease in SGaw (PD35) was determined. The histamine PD35 observed after inhalation of LTE4 was 0.46 mumol, and this was significantly less than the histamine PD35 observed after inhalation of methacholine (0.88 mumol; p less than 10(-4) and diluent (0.97 mumol; p less than 10(-5). Histamine responsiveness was also enhanced by a fiftyfold lower dose of LTE4 (p = 0.005), and the enhancement was less than that elicited by the higher dose of LTE4 in the same individuals (p = 0.02). The changes in histamine PD35 during a 1-week period after LTE4 and methacholine challenges were compared in four subjects with asthma. There was a time-dependent enhancement in histamine responsiveness that reached a maximal of 3.5-fold at 7 hours after LTE4. The enhancement had disappeared by 1 week. Similar changes were not observed after methacholine challenge, which elicited the same degree of bronchoconstriction as LTE4. Inhalation of LTE4 in five normal subjects that produced a mean 37.6% decrease in SGaw did not change histamine responsiveness for up to 7 hours. These findings suggest that LTE4 may play a role in the perpetuation of nonspecific airway hyperresponsiveness in bronchial asthma. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/2844876/The_effects_of_inhaled_leukotriene_E4_on_the_airway_responsiveness_to_histamine_in_subjects_with_asthma_and_normal_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-6749(88)90979-7 DB - PRIME DP - Unbound Medicine ER -