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Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains.
J Alzheimers Dis. 2017; 58(3):661-667.JA

Abstract

The two pathognomonic lesions in the brain of AD patients are senile plaques and intraneuronal neurofibrillary tangles (NFT). Previous studies have demonstrated that amyloid-β (Aβ) is a component of both senile plaques and NFTs, and have showed that intracellular accumulation of Aβ is toxic for cells and precedes the appearance of extracellular amyloid deposits. Here we report that there are numerous intraneuronal NFT and extraneuronal NFT immunoreactive for Aβx-40 in which there is no co-localization with tau staining suggesting the existence of two different neurodegenerating populations associated with the intracellular accumulation of either tau protein or Aβx-40 in AD.

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Publisher Full Text

Authors

Lacosta AM
No affiliation info available
Insua D
No affiliation info available
Badi H
No affiliation info available
Pesini P
No affiliation info available
Sarasa M
No affiliation info available

MeSH

AdultAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBrainDown SyndromeFemaleHumansImmunohistochemistryMaleMiddle AgedNeurofibrillary TanglesNeuronstau Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28453491

Citation

Lacosta, Ana-María, et al. "Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains." Journal of Alzheimer's Disease : JAD, vol. 58, no. 3, 2017, pp. 661-667.
Lacosta AM, Insua D, Badi H, et al. Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains. J Alzheimers Dis. 2017;58(3):661-667.
Lacosta, A. M., Insua, D., Badi, H., Pesini, P., & Sarasa, M. (2017). Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains. Journal of Alzheimer's Disease : JAD, 58(3), 661-667. https://doi.org/10.3233/JAD-170163
Lacosta AM, et al. Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains. J Alzheimers Dis. 2017;58(3):661-667. PubMed PMID: 28453491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains. AU - Lacosta,Ana-María, AU - Insua,Daniel, AU - Badi,Hassnae, AU - Pesini,Pedro, AU - Sarasa,Manuel, PY - 2017/4/30/pubmed PY - 2018/3/22/medline PY - 2017/4/29/entrez KW - Amyloid-β KW - Aβ peptides KW - immunohistochemistry KW - neurodegeneration KW - phosphorylated-tau KW - tau protein SP - 661 EP - 667 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 58 IS - 3 N2 - The two pathognomonic lesions in the brain of AD patients are senile plaques and intraneuronal neurofibrillary tangles (NFT). Previous studies have demonstrated that amyloid-β (Aβ) is a component of both senile plaques and NFTs, and have showed that intracellular accumulation of Aβ is toxic for cells and precedes the appearance of extracellular amyloid deposits. Here we report that there are numerous intraneuronal NFT and extraneuronal NFT immunoreactive for Aβx-40 in which there is no co-localization with tau staining suggesting the existence of two different neurodegenerating populations associated with the intracellular accumulation of either tau protein or Aβx-40 in AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/28453491/Neurofibrillary_Tangles_of_Aβx_40_in_Alzheimer's_Disease_Brains_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-170163 DB - PRIME DP - Unbound Medicine ER -