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Overexpression of N-cadherin and β-catenin correlates with poor prognosis in patients with nasopharyngeal carcinoma.
Oncol Lett 2017; 13(3):1725-1730OL

Abstract

An increasing amount of evidence demonstrates that epithelial-mesenchymal transition (EMT) is important in tumor invasion and metastases. The cell-cell adhesion molecule N-cadherin and the Wnt/β-catenin cascade protein β-catenin are two biomarkers of EMT. The present study aimed to measure the expression levels of N-cadherin and β-catenin in samples from patients with nasopharyngeal carcinoma (NPC) and evaluate their prognostic significance. N-cadherin and β-catenin mRNA was evaluated using reverse transcription-quantitative polymerase chain reaction in 26 NPC tissue samples and 8 nasopharyngeal epithelium samples. Protein expression of N-cadherin and β-catenin was also detected using immunohistochemistry in 128 archival NPC paraffin-embedded specimens. Finally, associations between clinical pathological parameters and prognostic values in NPC were evaluated. The results demonstrated that both the mRNA and protein levels of N-cadherin and β-catenin were significantly increased in NPC tissues compared with the controls. Enhanced expression of N-cadherin and β-catenin protein was strongly correlated with the status of lymph node metastasis and clinical stages in patients with NPC. Notably, high expression of N-cadherin and β-catenin proteins was significantly correlated with lower overall survival (OS) rate in patients with NPC. Finally, multivariate analysis demonstrated that expression of N-cadherin protein and clinical stages were independent prognostic factors for patients with NPC. Therefore, the present study demonstrated that N-cadherin and β-catenin expression may be used as potential prognostic biomarkers for patients with NPC.

Authors+Show Affiliations

Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28454316

Citation

Sun, Hong, et al. "Overexpression of N-cadherin and Β-catenin Correlates With Poor Prognosis in Patients With Nasopharyngeal Carcinoma." Oncology Letters, vol. 13, no. 3, 2017, pp. 1725-1730.
Sun H, Liu M, Wu X, et al. Overexpression of N-cadherin and β-catenin correlates with poor prognosis in patients with nasopharyngeal carcinoma. Oncol Lett. 2017;13(3):1725-1730.
Sun, H., Liu, M., Wu, X., Yang, C., Zhang, Y., Xu, Z., ... Wang, F. (2017). Overexpression of N-cadherin and β-catenin correlates with poor prognosis in patients with nasopharyngeal carcinoma. Oncology Letters, 13(3), pp. 1725-1730. doi:10.3892/ol.2017.5645.
Sun H, et al. Overexpression of N-cadherin and Β-catenin Correlates With Poor Prognosis in Patients With Nasopharyngeal Carcinoma. Oncol Lett. 2017;13(3):1725-1730. PubMed PMID: 28454316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overexpression of N-cadherin and β-catenin correlates with poor prognosis in patients with nasopharyngeal carcinoma. AU - Sun,Hong, AU - Liu,Mingyu, AU - Wu,Xuewen, AU - Yang,Chunguang, AU - Zhang,Yanni, AU - Xu,Zhenhang, AU - Gao,Kelei, AU - Wang,Fengjun, Y1 - 2017/01/25/ PY - 2016/01/12/received PY - 2016/10/27/accepted PY - 2017/4/30/entrez PY - 2017/4/30/pubmed PY - 2017/4/30/medline KW - N-cadherin KW - metastasis KW - nasopharyngeal carcinoma KW - prognosis KW - β-catenin SP - 1725 EP - 1730 JF - Oncology letters JO - Oncol Lett VL - 13 IS - 3 N2 - An increasing amount of evidence demonstrates that epithelial-mesenchymal transition (EMT) is important in tumor invasion and metastases. The cell-cell adhesion molecule N-cadherin and the Wnt/β-catenin cascade protein β-catenin are two biomarkers of EMT. The present study aimed to measure the expression levels of N-cadherin and β-catenin in samples from patients with nasopharyngeal carcinoma (NPC) and evaluate their prognostic significance. N-cadherin and β-catenin mRNA was evaluated using reverse transcription-quantitative polymerase chain reaction in 26 NPC tissue samples and 8 nasopharyngeal epithelium samples. Protein expression of N-cadherin and β-catenin was also detected using immunohistochemistry in 128 archival NPC paraffin-embedded specimens. Finally, associations between clinical pathological parameters and prognostic values in NPC were evaluated. The results demonstrated that both the mRNA and protein levels of N-cadherin and β-catenin were significantly increased in NPC tissues compared with the controls. Enhanced expression of N-cadherin and β-catenin protein was strongly correlated with the status of lymph node metastasis and clinical stages in patients with NPC. Notably, high expression of N-cadherin and β-catenin proteins was significantly correlated with lower overall survival (OS) rate in patients with NPC. Finally, multivariate analysis demonstrated that expression of N-cadherin protein and clinical stages were independent prognostic factors for patients with NPC. Therefore, the present study demonstrated that N-cadherin and β-catenin expression may be used as potential prognostic biomarkers for patients with NPC. SN - 1792-1074 UR - https://www.unboundmedicine.com/medline/citation/28454316/Overexpression_of_N_cadherin_and_β_catenin_correlates_with_poor_prognosis_in_patients_with_nasopharyngeal_carcinoma_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1792-1074&volume=13&issue=3&spage=1725&aulast=Sun DB - PRIME DP - Unbound Medicine ER -