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Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, Beijing, China.
Vaccine 2017; 35(23):3129-3134V

Abstract

BACKGROUND

Vaccination is recommended to prevent influenza virus infection and associated complications. This study aimed to estimate the influenza vaccine effectiveness (VE) against hospitalization in the 2015/16 season in Beijing.

METHODS

Patients who were hospitalized in the 5 study hospitals between 1 Oct 2015 and 15 May 2016 were recruited. Influenza vaccination status was obtained for PCR-confirmed influenza patients and the selected controls who tested negative for the virus. Conditional logistic regression was used to estimate the influenza VE matching by calendar week, and adjusting for age, study sites, underlying medical conditions, smoking status, and hospital admissions over the past 12months.

RESULTS

The overall VE was -37.9% (95% CI: -103.3, 6.5) against laboratory-confirmed influenza-associated hospitalization. The 2015-16 seasonal vaccine was had -61.9% (95% CI: -211.9, 15.9), -5.4% (95% CI: -108.1, 46.6) and -45.2% (95% CI: -152.6, 16.5) effectiveness to prevent infection from A(H1N1)pdm09, A(H3N2) and influenza B, respectively.

CONCLUSIONS

Influenza vaccination did not show effective protection against hospitalization with influenza in 2015/16 season in Beijing.

Authors+Show Affiliations

Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China; School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China.Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China.School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.Foundation for the Promotion of Health and Biomedical Research in the Valencia Region FISABIO - Public Health, Valencia, Spain.School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: bcowling@hku.hk.School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China. Electronic address: cfetpyhj@vip.sina.com.Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China. Electronic address: bjcdcxm@126.com.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28456530

Citation

Zhang, Yi, et al. "Influenza Vaccine Effectiveness Against Influenza-associated Hospitalization in 2015/16 Season, Beijing, China." Vaccine, vol. 35, no. 23, 2017, pp. 3129-3134.
Zhang Y, Wu P, Feng L, et al. Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, Beijing, China. Vaccine. 2017;35(23):3129-3134.
Zhang, Y., Wu, P., Feng, L., Yang, P., Pan, Y., Feng, S., ... Wang, Q. (2017). Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, Beijing, China. Vaccine, 35(23), pp. 3129-3134. doi:10.1016/j.vaccine.2017.03.084.
Zhang Y, et al. Influenza Vaccine Effectiveness Against Influenza-associated Hospitalization in 2015/16 Season, Beijing, China. Vaccine. 2017 05 25;35(23):3129-3134. PubMed PMID: 28456530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, Beijing, China. AU - Zhang,Yi, AU - Wu,Peng, AU - Feng,Luzhao, AU - Yang,Peng, AU - Pan,Yang, AU - Feng,Shuo, AU - Qin,Ying, AU - Zheng,Jiandong, AU - Puig-Barberà,Joan, AU - Muscatello,David, AU - MacIntyre,Raina, AU - Cowling,Benjamin J, AU - Yu,Hongjie, AU - Wang,Quanyi, Y1 - 2017/04/26/ PY - 2017/01/20/received PY - 2017/03/29/revised PY - 2017/03/30/accepted PY - 2017/5/1/pubmed PY - 2018/2/6/medline PY - 2017/5/1/entrez KW - Effectiveness KW - Hospitalization KW - Influenza KW - Test negative KW - Vaccine SP - 3129 EP - 3134 JF - Vaccine JO - Vaccine VL - 35 IS - 23 N2 - BACKGROUND: Vaccination is recommended to prevent influenza virus infection and associated complications. This study aimed to estimate the influenza vaccine effectiveness (VE) against hospitalization in the 2015/16 season in Beijing. METHODS: Patients who were hospitalized in the 5 study hospitals between 1 Oct 2015 and 15 May 2016 were recruited. Influenza vaccination status was obtained for PCR-confirmed influenza patients and the selected controls who tested negative for the virus. Conditional logistic regression was used to estimate the influenza VE matching by calendar week, and adjusting for age, study sites, underlying medical conditions, smoking status, and hospital admissions over the past 12months. RESULTS: The overall VE was -37.9% (95% CI: -103.3, 6.5) against laboratory-confirmed influenza-associated hospitalization. The 2015-16 seasonal vaccine was had -61.9% (95% CI: -211.9, 15.9), -5.4% (95% CI: -108.1, 46.6) and -45.2% (95% CI: -152.6, 16.5) effectiveness to prevent infection from A(H1N1)pdm09, A(H3N2) and influenza B, respectively. CONCLUSIONS: Influenza vaccination did not show effective protection against hospitalization with influenza in 2015/16 season in Beijing. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/28456530/Influenza_vaccine_effectiveness_against_influenza_associated_hospitalization_in_2015/16_season_Beijing_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(17)30436-X DB - PRIME DP - Unbound Medicine ER -