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Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats.
Psychopharmacology (Berl). 2017 Aug; 234(16):2431-2441.P

Abstract

RATIONALE

Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective.

OBJECTIVES

The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine memory reconsolidation.

METHODS

Rats were trained to lever press for cocaine infusions in a distinctive context, followed by extinction training in a different context. Rats in experiment 1 received bilateral microinfusions of vehicle or a GABA agonist cocktail (baclofen and muscimol (BM)) into the AI or the overlying somatosensory cortex (SSJ, anatomical control region) immediately before a test of drug-seeking behavior (i.e., non-reinforced lever presses) in the previously cocaine-paired context. The effects of these manipulations on locomotor activity were also assessed in a novel context. Rats in experiment 2 received vehicle or BM into the AI after a 15-min reexposure to the cocaine-paired context, intended to reactivate context-response-cocaine memories and initiate their reconsolidation. The effects of these manipulations on drug context-induced cocaine-seeking behavior were assessed 72 h later.

RESULTS

BM-induced pharmacological inactivation of the AI, but not the SSJ, attenuated drug context-induced reinstatement of cocaine-seeking behavior without altering locomotor activity. Conversely, AI inactivation after memory reactivation failed to impair subsequent drug-seeking behavior and thus cocaine memory reconsolidation.

CONCLUSIONS

These findings suggest that the AI is a critical element of the neural circuitry that mediates contextual control over cocaine-seeking behavior.

Authors+Show Affiliations

Department of Psychology, Michigan State University, East Lansing, MI, 48824, USA. Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, P.O. Box 647620, Pullman, WA, 99164-7620, USA.Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, P.O. Box 647620, Pullman, WA, 99164-7620, USA.Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, P.O. Box 647620, Pullman, WA, 99164-7620, USA.Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, P.O. Box 647620, Pullman, WA, 99164-7620, USA.Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, P.O. Box 647620, Pullman, WA, 99164-7620, USA.Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, P.O. Box 647620, Pullman, WA, 99164-7620, USA. ritafuchs@vetmed.wsu.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28462472

Citation

Arguello, Amy A., et al. "Role of the Agranular Insular Cortex in Contextual Control Over Cocaine-seeking Behavior in Rats." Psychopharmacology, vol. 234, no. 16, 2017, pp. 2431-2441.
Arguello AA, Wang R, Lyons CM, et al. Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2017;234(16):2431-2441.
Arguello, A. A., Wang, R., Lyons, C. M., Higginbotham, J. A., Hodges, M. A., & Fuchs, R. A. (2017). Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats. Psychopharmacology, 234(16), 2431-2441. https://doi.org/10.1007/s00213-017-4632-7
Arguello AA, et al. Role of the Agranular Insular Cortex in Contextual Control Over Cocaine-seeking Behavior in Rats. Psychopharmacology (Berl). 2017;234(16):2431-2441. PubMed PMID: 28462472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats. AU - Arguello,Amy A, AU - Wang,Rong, AU - Lyons,Carey M, AU - Higginbotham,Jessica A, AU - Hodges,Matthew A, AU - Fuchs,Rita A, Y1 - 2017/05/02/ PY - 2016/11/02/received PY - 2017/04/15/accepted PY - 2017/5/4/pubmed PY - 2018/3/27/medline PY - 2017/5/3/entrez KW - Agranular insular cortex KW - Baclofen muscimol KW - Cocaine seeking KW - Context KW - Memory reconsolidation KW - Reinstatement KW - Self-administration SP - 2431 EP - 2441 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 234 IS - 16 N2 - RATIONALE: Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective. OBJECTIVES: The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine memory reconsolidation. METHODS: Rats were trained to lever press for cocaine infusions in a distinctive context, followed by extinction training in a different context. Rats in experiment 1 received bilateral microinfusions of vehicle or a GABA agonist cocktail (baclofen and muscimol (BM)) into the AI or the overlying somatosensory cortex (SSJ, anatomical control region) immediately before a test of drug-seeking behavior (i.e., non-reinforced lever presses) in the previously cocaine-paired context. The effects of these manipulations on locomotor activity were also assessed in a novel context. Rats in experiment 2 received vehicle or BM into the AI after a 15-min reexposure to the cocaine-paired context, intended to reactivate context-response-cocaine memories and initiate their reconsolidation. The effects of these manipulations on drug context-induced cocaine-seeking behavior were assessed 72 h later. RESULTS: BM-induced pharmacological inactivation of the AI, but not the SSJ, attenuated drug context-induced reinstatement of cocaine-seeking behavior without altering locomotor activity. Conversely, AI inactivation after memory reactivation failed to impair subsequent drug-seeking behavior and thus cocaine memory reconsolidation. CONCLUSIONS: These findings suggest that the AI is a critical element of the neural circuitry that mediates contextual control over cocaine-seeking behavior. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/28462472/Role_of_the_agranular_insular_cortex_in_contextual_control_over_cocaine_seeking_behavior_in_rats_ L2 - https://dx.doi.org/10.1007/s00213-017-4632-7 DB - PRIME DP - Unbound Medicine ER -