Tags

Type your tag names separated by a space and hit enter

Selective dual cholinesterase inhibitors from Aconitum laeve.
J Asian Nat Prod Res. 2018 Feb; 20(2):172-181.JA

Abstract

New lycoctonine-type dual cholinesterase inhibitor, swatinine-C (1), along with three known norditerpenoid alkaloids, hohenackerine (2), aconorine (5) and lappaconitine (6) and two synthetically known but phytochemically new benzene derivatives, methyl 2-acetamidobenzoate (3) and methyl 4-[2-(methoxycarbonyl)anilino]-4-oxobutanoate (4), was isolated from the roots of A. laeve. Structures of new and known compounds (1-6) were established on the basis of latest spectroscopic techniques and by close comparison with the data available in literature. In vitro, compounds (1-6) were tested against AChE and BChE inhibitory activities. Compounds 1 and 2 showed competitive inhibition against AChE (IC50 = 3.7 μM, 4.53 μM) and BChE (IC50 = 12.23 μM, 9.94 μM), respectively. Compounds 5 and 6 showed promising noncompetitive type of inhibitory profile against AChE (IC50 = 2.51 and 6.13 μM) only. Compounds 3 and 4 showed weak inhibitory profile against both AChE and BChE.

Authors+Show Affiliations

a Department of Chemistry , University of Malakand , Dir (Lower) 18550 , Pakistan.a Department of Chemistry , University of Malakand , Dir (Lower) 18550 , Pakistan. b Department of Pharmacy , Shaheed Benazir Bhutto University Sheringal , Dir (Upper) 18000 , Pakistan.c Faculty of Pharmacy , Universiti Teknologi MARA , Bandar Puncak Alam 42300 , Malaysia. d Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA , Bandar Puncak Alam 42300 , Malaysia.e Department of Biotechnology, University of Science and Technology , Bannu 28100 , Pakistan.g Department of Chemistry , Shaheed Benazir Bhutto University Sheringal , Dir (Upper) 18000 , Pakistan.a Department of Chemistry , University of Malakand , Dir (Lower) 18550 , Pakistan.a Department of Chemistry , University of Malakand , Dir (Lower) 18550 , Pakistan.f HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi , Karachi 75270 , Pakistan.a Department of Chemistry , University of Malakand , Dir (Lower) 18550 , Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28463565

Citation

Ahmad, Hanif, et al. "Selective Dual Cholinesterase Inhibitors From Aconitum Laeve." Journal of Asian Natural Products Research, vol. 20, no. 2, 2018, pp. 172-181.
Ahmad H, Ahmad S, Shah SAA, et al. Selective dual cholinesterase inhibitors from Aconitum laeve. J Asian Nat Prod Res. 2018;20(2):172-181.
Ahmad, H., Ahmad, S., Shah, S. A. A., Khan, H. U., Khan, F. A., Ali, M., Latif, A., Shaheen, F., & Ahmad, M. (2018). Selective dual cholinesterase inhibitors from Aconitum laeve. Journal of Asian Natural Products Research, 20(2), 172-181. https://doi.org/10.1080/10286020.2017.1319820
Ahmad H, et al. Selective Dual Cholinesterase Inhibitors From Aconitum Laeve. J Asian Nat Prod Res. 2018;20(2):172-181. PubMed PMID: 28463565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective dual cholinesterase inhibitors from Aconitum laeve. AU - Ahmad,Hanif, AU - Ahmad,Shujaat, AU - Shah,Syed Adnan Ali, AU - Khan,Hidayat Ullah, AU - Khan,Farman Ali, AU - Ali,Mumtaz, AU - Latif,Abdul, AU - Shaheen,Farzana, AU - Ahmad,Manzoor, Y1 - 2017/05/02/ PY - 2017/5/4/pubmed PY - 2018/2/3/medline PY - 2017/5/3/entrez KW - Aconitum laeve KW - acetyl cholinesterase (AChE) & butyrylcholinesterase (BChE) inhibition KW - diterpenoid alkaloids KW - methyl 2-acetamidobenzoate KW - methyl-4-[2-(methoxycarbonyl)anilino]-4-oxobutanoate KW - swatinine-C SP - 172 EP - 181 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 20 IS - 2 N2 - New lycoctonine-type dual cholinesterase inhibitor, swatinine-C (1), along with three known norditerpenoid alkaloids, hohenackerine (2), aconorine (5) and lappaconitine (6) and two synthetically known but phytochemically new benzene derivatives, methyl 2-acetamidobenzoate (3) and methyl 4-[2-(methoxycarbonyl)anilino]-4-oxobutanoate (4), was isolated from the roots of A. laeve. Structures of new and known compounds (1-6) were established on the basis of latest spectroscopic techniques and by close comparison with the data available in literature. In vitro, compounds (1-6) were tested against AChE and BChE inhibitory activities. Compounds 1 and 2 showed competitive inhibition against AChE (IC50 = 3.7 μM, 4.53 μM) and BChE (IC50 = 12.23 μM, 9.94 μM), respectively. Compounds 5 and 6 showed promising noncompetitive type of inhibitory profile against AChE (IC50 = 2.51 and 6.13 μM) only. Compounds 3 and 4 showed weak inhibitory profile against both AChE and BChE. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/28463565/Selective_dual_cholinesterase_inhibitors_from_Aconitum_laeve_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020.2017.1319820 DB - PRIME DP - Unbound Medicine ER -