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Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities.
Biomed Pharmacother. 2017 Jul; 91:338-349.BP

Abstract

Gastritis is preponderantly characterized by inflammation of the lining epithelial layer and the chronic gastritis is considered as a pre-cancer lesion. For many centuries olive (Olea europaea) leaf has been used for its putative health potential, nonetheless, to date, the gastroprotective effects of olive leaves have not been studied yet. Hence, in this study we investigated whether olive leaf extract (OLE) could protect gastric mucosa against HCl/ethanol-induced gastric mucosal damage in rats. Hcl/ethanol administration caused significant damage to the gastric mucosa, as confirmed by gastric ulcer index and histological evaluation. However, this damage was largely prevented by pre-administering 20mg/kg omeprazole or 100mg/kg OLE. Interestingly, the damage was completely prevented by pre-administering 200 and 300mg/kg OLE. Moreover, OLE attenuated the inflammatory response by decreasing nuclear factor-κB (NF-κB), cycloxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α) expressions, and down-regulating inducible nitric oxide synthase (iNOS) and interleukin-1β (IL-1β) in gastric mucosa. The gastroprotective mechanism of OLE involved the promotion of enzymatic and nonenzymatic molecules (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione reduced form), promoting nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA expression, halting lipid peroxidation and preventing the overproduction of nitric oxide. Together, our findings clearly demonstrated that OLE could prevent HCl/ethanol-induced gastritis by attenuating inflammation and oxidant/antioxidant imbalance. Indeed, OLE could potentially be useful as a natural therapy for gastritis.

Authors+Show Affiliations

Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.Faculty of Preparatory Year, University of Hail, Hail, Saudi Arabia; Faculty of Biotechnology, October University for Modern Science and Arts (MSA), Giza, Egypt.Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt. Electronic address: aest1977@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28463797

Citation

Al-Quraishy, Saleh, et al. "Olive (Olea Europaea) Leaf Methanolic Extract Prevents HCl/ethanol-induced Gastritis in Rats By Attenuating Inflammation and Augmenting Antioxidant Enzyme Activities." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 91, 2017, pp. 338-349.
Al-Quraishy S, Othman MS, Dkhil MA, et al. Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. Biomed Pharmacother. 2017;91:338-349.
Al-Quraishy, S., Othman, M. S., Dkhil, M. A., & Abdel Moneim, A. E. (2017). Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 91, 338-349. https://doi.org/10.1016/j.biopha.2017.04.069
Al-Quraishy S, et al. Olive (Olea Europaea) Leaf Methanolic Extract Prevents HCl/ethanol-induced Gastritis in Rats By Attenuating Inflammation and Augmenting Antioxidant Enzyme Activities. Biomed Pharmacother. 2017;91:338-349. PubMed PMID: 28463797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. AU - Al-Quraishy,Saleh, AU - Othman,Mohamed S, AU - Dkhil,Mohamed A, AU - Abdel Moneim,Ahmed Esmat, Y1 - 2017/05/02/ PY - 2017/01/07/received PY - 2017/03/24/revised PY - 2017/04/17/accepted PY - 2017/5/4/pubmed PY - 2018/3/27/medline PY - 2017/5/3/entrez KW - Antioxidant KW - Gastritis KW - HCl/ethanol KW - Inflammation KW - Olive leaf SP - 338 EP - 349 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 91 N2 - Gastritis is preponderantly characterized by inflammation of the lining epithelial layer and the chronic gastritis is considered as a pre-cancer lesion. For many centuries olive (Olea europaea) leaf has been used for its putative health potential, nonetheless, to date, the gastroprotective effects of olive leaves have not been studied yet. Hence, in this study we investigated whether olive leaf extract (OLE) could protect gastric mucosa against HCl/ethanol-induced gastric mucosal damage in rats. Hcl/ethanol administration caused significant damage to the gastric mucosa, as confirmed by gastric ulcer index and histological evaluation. However, this damage was largely prevented by pre-administering 20mg/kg omeprazole or 100mg/kg OLE. Interestingly, the damage was completely prevented by pre-administering 200 and 300mg/kg OLE. Moreover, OLE attenuated the inflammatory response by decreasing nuclear factor-κB (NF-κB), cycloxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α) expressions, and down-regulating inducible nitric oxide synthase (iNOS) and interleukin-1β (IL-1β) in gastric mucosa. The gastroprotective mechanism of OLE involved the promotion of enzymatic and nonenzymatic molecules (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione reduced form), promoting nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA expression, halting lipid peroxidation and preventing the overproduction of nitric oxide. Together, our findings clearly demonstrated that OLE could prevent HCl/ethanol-induced gastritis by attenuating inflammation and oxidant/antioxidant imbalance. Indeed, OLE could potentially be useful as a natural therapy for gastritis. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/28463797/Olive__Olea_europaea__leaf_methanolic_extract_prevents_HCl/ethanol_induced_gastritis_in_rats_by_attenuating_inflammation_and_augmenting_antioxidant_enzyme_activities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)30092-6 DB - PRIME DP - Unbound Medicine ER -