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Successful treatment with SMS 201-995 of Cushing's syndrome caused by ectopic adrenocorticotropin secretion from a metastatic gastrin-secreting pancreatic islet cell carcinoma.
J Clin Endocrinol Metab. 1988 Nov; 67(5):1080-3.JC

Abstract

Signs and symptoms of Cushing's syndrome developed rapidly after total gastrectomy in a 37-yr-old man with a metastatic gastrin-secreting islet cell carcinoma. Argyrophilic tumor cells in a lymph node removed during operation immunostained for gastrin and ACTH. Treatment for more than 6 months with the somatostatin analog SMS 201-995 (300 micrograms/day) greatly reduced serum gastrin levels and normalized plasma ACTH and cortisol levels and urinary cortisol excretion, and the signs and symptoms of Cushing's syndrome disappeared. The size of the primary tumor in the head of the pancreas, which had grown rapidly before SMS 201-995 therapy, stabilized after 6 months of treatment with the analog. We conclude that SMS 201-995 can reduce ACTH as well as gastrin secretion from islet cell carcinomas as well as control tumor growth.

Authors+Show Affiliations

Department of Medicine, Erasmus University, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2846625

Citation

Lamberts, S W., et al. "Successful Treatment With SMS 201-995 of Cushing's Syndrome Caused By Ectopic Adrenocorticotropin Secretion From a Metastatic Gastrin-secreting Pancreatic Islet Cell Carcinoma." The Journal of Clinical Endocrinology and Metabolism, vol. 67, no. 5, 1988, pp. 1080-3.
Lamberts SW, Tilanus HW, Klooswijk AI, et al. Successful treatment with SMS 201-995 of Cushing's syndrome caused by ectopic adrenocorticotropin secretion from a metastatic gastrin-secreting pancreatic islet cell carcinoma. J Clin Endocrinol Metab. 1988;67(5):1080-3.
Lamberts, S. W., Tilanus, H. W., Klooswijk, A. I., Bruining, H. A., van der Lely, A. J., & de Jong, F. H. (1988). Successful treatment with SMS 201-995 of Cushing's syndrome caused by ectopic adrenocorticotropin secretion from a metastatic gastrin-secreting pancreatic islet cell carcinoma. The Journal of Clinical Endocrinology and Metabolism, 67(5), 1080-3.
Lamberts SW, et al. Successful Treatment With SMS 201-995 of Cushing's Syndrome Caused By Ectopic Adrenocorticotropin Secretion From a Metastatic Gastrin-secreting Pancreatic Islet Cell Carcinoma. J Clin Endocrinol Metab. 1988;67(5):1080-3. PubMed PMID: 2846625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment with SMS 201-995 of Cushing's syndrome caused by ectopic adrenocorticotropin secretion from a metastatic gastrin-secreting pancreatic islet cell carcinoma. AU - Lamberts,S W, AU - Tilanus,H W, AU - Klooswijk,A I, AU - Bruining,H A, AU - van der Lely,A J, AU - de Jong,F H, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 1080 EP - 3 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 67 IS - 5 N2 - Signs and symptoms of Cushing's syndrome developed rapidly after total gastrectomy in a 37-yr-old man with a metastatic gastrin-secreting islet cell carcinoma. Argyrophilic tumor cells in a lymph node removed during operation immunostained for gastrin and ACTH. Treatment for more than 6 months with the somatostatin analog SMS 201-995 (300 micrograms/day) greatly reduced serum gastrin levels and normalized plasma ACTH and cortisol levels and urinary cortisol excretion, and the signs and symptoms of Cushing's syndrome disappeared. The size of the primary tumor in the head of the pancreas, which had grown rapidly before SMS 201-995 therapy, stabilized after 6 months of treatment with the analog. We conclude that SMS 201-995 can reduce ACTH as well as gastrin secretion from islet cell carcinomas as well as control tumor growth. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2846625/Successful_treatment_with_SMS_201_995_of_Cushing's_syndrome_caused_by_ectopic_adrenocorticotropin_secretion_from_a_metastatic_gastrin_secreting_pancreatic_islet_cell_carcinoma_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-67-5-1080 DB - PRIME DP - Unbound Medicine ER -