Tags

Type your tag names separated by a space and hit enter

The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery.
Nutrients. 2017 May 03; 9(5)N

Abstract

BACKGROUND

Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects.

METHODS

We included 5802 men and women (age range: 55-80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery.

RESULTS

During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group.

CONCLUSIONS

To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery.

Authors+Show Affiliations

Department of Ophthalmology, University of Navarra, 31008 Pamplona, Spain. aglayana@unav.es.Department of Ophthalmology, University of Navarra, 31008 Pamplona, Spain. gciufo@unav.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. etoledo@unav.es. The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. etoledo@unav.es. Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain. etoledo@unav.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. mamartinez@unav.es. The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. mamartinez@unav.es. Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain. mamartinez@unav.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. dolores.corella@uv.es. Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain. dolores.corella@uv.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. mfito@imim.es. Cardiovascular Risk and Nutrition (Regicor Study Group), Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain. mfito@imim.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. restruch@clinic.ub.es. The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. restruch@clinic.ub.es. Department of Internal Medicine, August Pi i Sunyer Institute of Biomedical Research (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. restruch@clinic.ub.es.The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. egomezgracia@uma.es. Department of Preventive Medicine, University of Malaga, 29016 Malaga, Spain. egomezgracia@uma.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. miguel.fiol@ssib.es. Institute of Health Sciences, University of Balearic Islands and Son Espases Hospital, 07122 Palma de Mallorca, Spain. miguel.fiol@ssib.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. jlapetra@ono.com. Department of Family Medicine, Distrito Sanitario Atención Primaria Sevilla, Centro de Salud San Pablo, 41007 Sevilla, Spain. jlapetra@ono.com.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. lluis.serra@ulpgc.es. The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. lluis.serra@ulpgc.es. Department of Clinical Sciences, University of Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain. lluis.serra@ulpgc.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. xpinto@bellvitgehospital.cat. The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. xpinto@bellvitgehospital.cat. Lipids and Vascular Risk Units. Internal Medicine, University Hospital of Bellvitge, Hospitalet de Llobregat, 08907 Barcelona, Spain. xpinto@bellvitgehospital.cat.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. mariapuy.portillo@ehu.es. Nutrition and Obesity Group Department of Nutrition and Food Science, University of Basque Country and Lucio Lascaray Research Center, 48940 Vitoria, Spain. mariapuy.portillo@ehu.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. sorli@uv.es. Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain. sorli@uv.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. monica.bullo@urv.cat. The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. monica.bullo@urv.cat. Human Nutrition Unit, Faculty of Medicine and Health Sciences, IISPV, Rovira i Virgili University, 43003 Reus, Spain. monica.bullo@urv.cat.Cap La Mina, University of Barcelona, 08930 Barcelona, Spain. evinyoles@fundaciojgol.org.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. asala@clinic.cat. Lipid Clinic, Endocrinology and Nutrition Service, IDIBAPS, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. asala@clinic.cat.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. EROS@clinic.ub.es. Lipid Clinic, Endocrinology and Nutrition Service, IDIBAPS, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. EROS@clinic.ub.es.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. jordi.salas@urv.cat. The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. jordi.salas@urv.cat. Human Nutrition Unit, Faculty of Medicine and Health Sciences, IISPV, Rovira i Virgili University, 43003 Reus, Spain. jordi.salas@urv.cat.CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. aborau@secardiologia.es. The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD/06/0045), Instituto de Salud Carlos III (ISC III), 28029 Madrid, Spain. aborau@secardiologia.es. Department of Cardiology, University Hospital Araba, 01009 Vitoria, Spain. aborau@secardiologia.es.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

28467363

Citation

García-Layana, Alfredo, et al. "The Effect of a Mediterranean Diet On the Incidence of Cataract Surgery." Nutrients, vol. 9, no. 5, 2017.
García-Layana A, Ciufo G, Toledo E, et al. The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery. Nutrients. 2017;9(5).
García-Layana, A., Ciufo, G., Toledo, E., Martínez-González, M. A., Corella, D., Fitó, M., Estruch, R., Gómez-Gracia, E., Fiol, M., Lapetra, J., Serra-Majem, L., Pintó, X., Portillo, M. P., Sorli, J. V., Bulló, M., Vinyoles, E., Sala-Vila, A., Ros, E., Salas-Salvadó, J., & Arós, F. (2017). The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery. Nutrients, 9(5). https://doi.org/10.3390/nu9050453
García-Layana A, et al. The Effect of a Mediterranean Diet On the Incidence of Cataract Surgery. Nutrients. 2017 May 3;9(5) PubMed PMID: 28467363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery. AU - García-Layana,Alfredo, AU - Ciufo,Gianfranco, AU - Toledo,Estefania, AU - Martínez-González,Miguel A, AU - Corella,Dolores, AU - Fitó,Montse, AU - Estruch,Ramon, AU - Gómez-Gracia,Enrique, AU - Fiol,Miguel, AU - Lapetra,José, AU - Serra-Majem,Lluís, AU - Pintó,Xavier, AU - Portillo,Maria P, AU - Sorli,José V, AU - Bulló,Mónica, AU - Vinyoles,Ernest, AU - Sala-Vila,Aleix, AU - Ros,Emilio, AU - Salas-Salvadó,Jordi, AU - Arós,Fernando, Y1 - 2017/05/03/ PY - 2017/04/02/received PY - 2017/04/21/revised PY - 2017/04/28/accepted PY - 2017/5/4/entrez PY - 2017/5/4/pubmed PY - 2018/3/29/medline KW - Mediterranean diet KW - PREDIMED KW - antioxidants KW - cataract KW - cataract surgery KW - extra-virgin olive oil KW - low-fat diet KW - nuts JF - Nutrients JO - Nutrients VL - 9 IS - 5 N2 - BACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. METHODS: We included 5802 men and women (age range: 55-80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. RESULTS: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. CONCLUSIONS: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/28467363/The_Effect_of_a_Mediterranean_Diet_on_the_Incidence_of_Cataract_Surgery_ L2 - http://www.mdpi.com/resolver?pii=nu9050453 DB - PRIME DP - Unbound Medicine ER -