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Mitochondrial miRNAs in diabetes: just the tip of the iceberg.
Can J Physiol Pharmacol. 2017 Oct; 95(10):1156-1162.CJ

Abstract

Over the last 2 decades, mi(cro)RNAs have emerged as one of the key regulators of metabolic homeostasis. Most of the studies have highlighted that, in the cytoplasm, miRNAs directly bind to the 3'-UTR (untranslated region) of a mRNA. Conventional RNA-induced silencing complex (RISC) formation results in the post-transcriptional inhibition. This process is known to contribute to the development of metabolic diseases, including diabetes mellitus. Recent advancements with small RNA detection technologies have enabled us to identify miRNAs in the mitochondrial compartment of the cells. We have termed these miRNAs, which translocate into the mitochondria as mitochondrial miRNA, MitomiR. It has been demonstrated that MitomiRs can regulate gene expression, with some evidence even suggesting that, after translocation, MitomiRs can bind to the 3'-end of a mitochondrial gene, altering its regulation. Our main focus in this review is to highlight the potential role of MitomiR in the pathogenesis of metabolic disorders such as diabetes mellitus.

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Authors+Show Affiliations

Baradan R
a Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA. b School of Life Sciences, B.S. Abdur Rahman University, Tamilnadu, India.
Hollander JM
c Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA.
Das S
a Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

MeSH

3' Untranslated RegionsAnimalsBinding SitesDiabetes MellitusDiabetic CardiomyopathiesEnergy MetabolismGene Expression RegulationHumansMicroRNAsMitochondriaRNARNA, Mitochondrial

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28467860

Citation

Baradan, Rohini, et al. "Mitochondrial miRNAs in Diabetes: Just the Tip of the Iceberg." Canadian Journal of Physiology and Pharmacology, vol. 95, no. 10, 2017, pp. 1156-1162.
Baradan R, Hollander JM, Das S. Mitochondrial miRNAs in diabetes: just the tip of the iceberg. Can J Physiol Pharmacol. 2017;95(10):1156-1162.
Baradan, R., Hollander, J. M., & Das, S. (2017). Mitochondrial miRNAs in diabetes: just the tip of the iceberg. Canadian Journal of Physiology and Pharmacology, 95(10), 1156-1162. https://doi.org/10.1139/cjpp-2016-0580
Baradan R, Hollander JM, Das S. Mitochondrial miRNAs in Diabetes: Just the Tip of the Iceberg. Can J Physiol Pharmacol. 2017;95(10):1156-1162. PubMed PMID: 28467860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial miRNAs in diabetes: just the tip of the iceberg. AU - Baradan,Rohini, AU - Hollander,John M, AU - Das,Samarjit, Y1 - 2017/05/03/ PY - 2017/5/4/pubmed PY - 2018/2/6/medline PY - 2017/5/4/entrez KW - MitomiR KW - diabetes KW - diabète KW - metabolism KW - microARN mitochondrial KW - mitochondria KW - mitochondrial microRNA KW - mitochondrie KW - mitomiR KW - métabolisme SP - 1156 EP - 1162 JF - Canadian journal of physiology and pharmacology JO - Can J Physiol Pharmacol VL - 95 IS - 10 N2 - Over the last 2 decades, mi(cro)RNAs have emerged as one of the key regulators of metabolic homeostasis. Most of the studies have highlighted that, in the cytoplasm, miRNAs directly bind to the 3'-UTR (untranslated region) of a mRNA. Conventional RNA-induced silencing complex (RISC) formation results in the post-transcriptional inhibition. This process is known to contribute to the development of metabolic diseases, including diabetes mellitus. Recent advancements with small RNA detection technologies have enabled us to identify miRNAs in the mitochondrial compartment of the cells. We have termed these miRNAs, which translocate into the mitochondria as mitochondrial miRNA, MitomiR. It has been demonstrated that MitomiRs can regulate gene expression, with some evidence even suggesting that, after translocation, MitomiRs can bind to the 3'-end of a mitochondrial gene, altering its regulation. Our main focus in this review is to highlight the potential role of MitomiR in the pathogenesis of metabolic disorders such as diabetes mellitus. SN - 1205-7541 UR - https://www.unboundmedicine.com/medline/citation/28467860/Mitochondrial_miRNAs_in_diabetes:_just_the_tip_of_the_iceberg_ L2 - https://cdnsciencepub.com/doi/10.1139/cjpp-2016-0580?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -