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Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study.
Br J Nutr. 2017 Apr; 117(7):985-993.BJ

Abstract

We investigated associations between serum 25-hydroxyvitamin D (25(OH)D) in pregnancy and birth weight and other neonatal anthropometric measures. The present study was a population-based, multiethnic cohort study of 719 pregnant women (59 % ethnic minorities) in Oslo, Norway, delivering a singleton neonate at term and with birth weight measurements. In a representative sample, anthropometric measurements were taken. Maternal 25(OH)D was measured at gestational weeks 15 and 28. Women with 25(OH)D <37 nmol/l were recommended vitamin D3 supplementation. Separate linear regression analyses were performed to model the associations between 25(OH)D and each of the outcomes: birth weight, crown-heel length, head circumference, abdominal circumference, sum of skinfolds, mid-upper arm circumference and ponderal index. In early pregnancy, 51 % of the women were vitamin D deficient (25(OH)D<50 nmol/l). In univariate analyses and in models adjusting for maternal age, parity, education, prepregnancy BMI, season, gestational age and neonate sex, maternal 25(OH)D was significantly associated with birth weight, head circumference, abdominal circumference and ponderal index (P<0·05 for all), when used as a continuous variable and categorised (consistently low, consistently high, increasing and decreasing level). However, after adjusting for ethnicity, 25(OH)D was no longer associated with any of the outcomes. Sex-specific associations for abdominal circumference and sum of skinfolds were found (P for interaction<0·05). In conclusion, in a multiethnic cohort of pregnant women with high prevalence of vitamin D deficiency, we found no independent relation between maternal vitamin D levels and any of the neonatal anthropometric measures, and the strong association between ethnicity and neonatal outcomes was not affected by maternal vitamin D status.

Authors+Show Affiliations

1Department of General Practice,Institute of Health and Society,University of Oslo,N-0318 Oslo,Norway.1Department of General Practice,Institute of Health and Society,University of Oslo,N-0318 Oslo,Norway.1Department of General Practice,Institute of Health and Society,University of Oslo,N-0318 Oslo,Norway.1Department of General Practice,Institute of Health and Society,University of Oslo,N-0318 Oslo,Norway.1Department of General Practice,Institute of Health and Society,University of Oslo,N-0318 Oslo,Norway.2Department of Child and Adolescence Medicine,Akershus University Hospital,N-1478 Lørenskog,Norway.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28468694

Citation

Eggemoen, Åse R., et al. "Vitamin D Levels During Pregnancy and Associations With Birth Weight and Body Composition of the Newborn: a Longitudinal Multiethnic Population-based Study." The British Journal of Nutrition, vol. 117, no. 7, 2017, pp. 985-993.
Eggemoen ÅR, Jenum AK, Mdala I, et al. Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study. Br J Nutr. 2017;117(7):985-993.
Eggemoen, Å. R., Jenum, A. K., Mdala, I., Knutsen, K. V., Lagerløv, P., & Sletner, L. (2017). Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study. The British Journal of Nutrition, 117(7), 985-993. https://doi.org/10.1017/S000711451700068X
Eggemoen ÅR, et al. Vitamin D Levels During Pregnancy and Associations With Birth Weight and Body Composition of the Newborn: a Longitudinal Multiethnic Population-based Study. Br J Nutr. 2017;117(7):985-993. PubMed PMID: 28468694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study. AU - Eggemoen,Åse R, AU - Jenum,Anne K, AU - Mdala,Ibrahimu, AU - Knutsen,Kirsten V, AU - Lagerløv,Per, AU - Sletner,Line, Y1 - 2017/05/04/ PY - 2017/5/5/pubmed PY - 2017/7/27/medline PY - 2017/5/5/entrez KW - 25(OH)D 25-hydroxyvitamin D KW - GW gestational week KW - SGA small for gestational age KW - Anthropometric measures KW - Birth weight KW - Body composition KW - Deficiencies KW - Ethnic minorities KW - Pregnancy KW - Vitamin D SP - 985 EP - 993 JF - The British journal of nutrition JO - Br J Nutr VL - 117 IS - 7 N2 - We investigated associations between serum 25-hydroxyvitamin D (25(OH)D) in pregnancy and birth weight and other neonatal anthropometric measures. The present study was a population-based, multiethnic cohort study of 719 pregnant women (59 % ethnic minorities) in Oslo, Norway, delivering a singleton neonate at term and with birth weight measurements. In a representative sample, anthropometric measurements were taken. Maternal 25(OH)D was measured at gestational weeks 15 and 28. Women with 25(OH)D <37 nmol/l were recommended vitamin D3 supplementation. Separate linear regression analyses were performed to model the associations between 25(OH)D and each of the outcomes: birth weight, crown-heel length, head circumference, abdominal circumference, sum of skinfolds, mid-upper arm circumference and ponderal index. In early pregnancy, 51 % of the women were vitamin D deficient (25(OH)D<50 nmol/l). In univariate analyses and in models adjusting for maternal age, parity, education, prepregnancy BMI, season, gestational age and neonate sex, maternal 25(OH)D was significantly associated with birth weight, head circumference, abdominal circumference and ponderal index (P<0·05 for all), when used as a continuous variable and categorised (consistently low, consistently high, increasing and decreasing level). However, after adjusting for ethnicity, 25(OH)D was no longer associated with any of the outcomes. Sex-specific associations for abdominal circumference and sum of skinfolds were found (P for interaction<0·05). In conclusion, in a multiethnic cohort of pregnant women with high prevalence of vitamin D deficiency, we found no independent relation between maternal vitamin D levels and any of the neonatal anthropometric measures, and the strong association between ethnicity and neonatal outcomes was not affected by maternal vitamin D status. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/28468694/Vitamin_D_levels_during_pregnancy_and_associations_with_birth_weight_and_body_composition_of_the_newborn:_a_longitudinal_multiethnic_population_based_study_ L2 - https://www.cambridge.org/core/product/identifier/S000711451700068X/type/journal_article DB - PRIME DP - Unbound Medicine ER -