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Lens membrane properties following hydrogen peroxide exposure.
Ophthalmic Res. 1988; 20(3):200-4.OR

Abstract

Rabbit lenses exposed to 0.5 mM hydrogen peroxide for 1 h and then incubated for an additional 19 h demonstrated small yet significant changes in electrolyte balance. Active cation pumping by the lens, as determined by 86Rb uptake studies, was partially impaired following 1 h hydrogen peroxide exposure; the cation pump further deteriorated during the subsequent 19-hour incubation. Passive membrane permeability of the lens, measured by 86Rb efflux, was elevated following 1 h hydrogen peroxide but no further increase in leakiness was observed during the subsequent 19-hour incubation. These findings suggest that even relatively brief exposure to oxidative damage initiates a chain of events from which the lens is unable to recover.

Authors+Show Affiliations

Department of Ophthalmology, University of Louisville, Ky.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2847099

Citation

Delamere, N A., et al. "Lens Membrane Properties Following Hydrogen Peroxide Exposure." Ophthalmic Research, vol. 20, no. 3, 1988, pp. 200-4.
Delamere NA, Paterson CA, Hensley S. Lens membrane properties following hydrogen peroxide exposure. Ophthalmic Res. 1988;20(3):200-4.
Delamere, N. A., Paterson, C. A., & Hensley, S. (1988). Lens membrane properties following hydrogen peroxide exposure. Ophthalmic Research, 20(3), 200-4.
Delamere NA, Paterson CA, Hensley S. Lens Membrane Properties Following Hydrogen Peroxide Exposure. Ophthalmic Res. 1988;20(3):200-4. PubMed PMID: 2847099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lens membrane properties following hydrogen peroxide exposure. AU - Delamere,N A, AU - Paterson,C A, AU - Hensley,S, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 200 EP - 4 JF - Ophthalmic research JO - Ophthalmic Res VL - 20 IS - 3 N2 - Rabbit lenses exposed to 0.5 mM hydrogen peroxide for 1 h and then incubated for an additional 19 h demonstrated small yet significant changes in electrolyte balance. Active cation pumping by the lens, as determined by 86Rb uptake studies, was partially impaired following 1 h hydrogen peroxide exposure; the cation pump further deteriorated during the subsequent 19-hour incubation. Passive membrane permeability of the lens, measured by 86Rb efflux, was elevated following 1 h hydrogen peroxide but no further increase in leakiness was observed during the subsequent 19-hour incubation. These findings suggest that even relatively brief exposure to oxidative damage initiates a chain of events from which the lens is unable to recover. SN - 0030-3747 UR - https://www.unboundmedicine.com/medline/citation/2847099/Lens_membrane_properties_following_hydrogen_peroxide_exposure_ L2 - https://www.karger.com?DOI=10.1159/000266586 DB - PRIME DP - Unbound Medicine ER -