Tags

Type your tag names separated by a space and hit enter

The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age.
Child Obes 2017; 13(5):392-399CO

Abstract

BACKGROUND

Obesity is a complex disease that involves both environmental and genetic factors in its pathogenesis. Several studies have identified multiple obesity-associated loci in many populations. However, their contribution to obesity in the Vietnamese population is not fully described, especially in children. The study aimed to investigate the association of obesity with Val66Met polymorphism in brain-derived neurotrophic factor (BDNF) gene, delivery method, birth weight, and lifestyle factors in Vietnamese primary school children.

METHODS

A case-control study was conducted on 559 children aged 6-11 years (278 obese cases and 281 normal controls). The obesity of the children was classified using both criteria of International Obesity Task Force (IOTF, 2000) and World Health Organization (WHO, 2007). Lifestyle factors, birth delivery, and birth weight of the children were self-reported by parents. The BDNF genotype was analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. Association was evaluated by multivariate logistic regression and cross-validated by the Bayesian model averaging method.

RESULTS

The most significantly independent factors for obesity were delivery method (cesarean section vs. vaginal delivery, β = 0.56, p = 0.007), birth weight (>3500 to <4000 g vs. 2500-3500 g, β = 0.52, p = 0.035; ≥4000 g vs. 2500-3500 g, β = 1.06, p = 0.015), night sleep duration (<8 h/day vs. ≥8 h/day, β = 0.99, p < 0.0001), and BDNF Val66Met polymorphism (AA and GG vs. AG, β = 0.38, p = 0.039).

CONCLUSIONS

The study suggested the significant association of delivery method, birth weight, night sleep duration, and BDNF Val66Met polymorphism, with obesity in Vietnamese primary school children.

Authors+Show Affiliations

1 Department of Biology, Hanoi National University of Education , Hanoi, Vietnam .2 National Institute of Nutrition , Hanoi, Vietnam .1 Department of Biology, Hanoi National University of Education , Hanoi, Vietnam .1 Department of Biology, Hanoi National University of Education , Hanoi, Vietnam .2 National Institute of Nutrition , Hanoi, Vietnam .2 National Institute of Nutrition , Hanoi, Vietnam . 3 Laboratory of Molecular Genetics, Department of Immunology and Molecular Biology, National Institute of Hygiene and Epidemiology , Hanoi, Vietnam . 4 Dinh Tien Hoang Institute of Medicine , Hanoi, Vietnam .5 National Hospital of Otorhinolaryngology , Hanoi, Vietnam .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28471701

Citation

Tuyet, Le Thi, et al. "The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age." Childhood Obesity (Print), vol. 13, no. 5, 2017, pp. 392-399.
Tuyet LT, Nhung BT, Dao DTA, et al. The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age. Child Obes. 2017;13(5):392-399.
Tuyet, L. T., Nhung, B. T., Dao, D. T. A., Hanh, N. T. H., Tuyen, L. D., Binh, T. Q., & Thuc, V. T. M. (2017). The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age. Childhood Obesity (Print), 13(5), pp. 392-399. doi:10.1089/chi.2017.0007.
Tuyet LT, et al. The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age. Child Obes. 2017;13(5):392-399. PubMed PMID: 28471701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age. AU - Tuyet,Le Thi, AU - Nhung,Bui Thi, AU - Dao,Duong Thi Anh, AU - Hanh,Nguyen Thi Hong, AU - Tuyen,Le Danh, AU - Binh,Tran Quang, AU - Thuc,Vu Thi Minh, Y1 - 2017/05/04/ PY - 2017/5/5/pubmed PY - 2018/5/31/medline PY - 2017/5/5/entrez KW - BDNF-rs6265 KW - Vietnamese children KW - associated factors KW - obesity SP - 392 EP - 399 JF - Childhood obesity (Print) JO - Child Obes VL - 13 IS - 5 N2 - BACKGROUND: Obesity is a complex disease that involves both environmental and genetic factors in its pathogenesis. Several studies have identified multiple obesity-associated loci in many populations. However, their contribution to obesity in the Vietnamese population is not fully described, especially in children. The study aimed to investigate the association of obesity with Val66Met polymorphism in brain-derived neurotrophic factor (BDNF) gene, delivery method, birth weight, and lifestyle factors in Vietnamese primary school children. METHODS: A case-control study was conducted on 559 children aged 6-11 years (278 obese cases and 281 normal controls). The obesity of the children was classified using both criteria of International Obesity Task Force (IOTF, 2000) and World Health Organization (WHO, 2007). Lifestyle factors, birth delivery, and birth weight of the children were self-reported by parents. The BDNF genotype was analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. Association was evaluated by multivariate logistic regression and cross-validated by the Bayesian model averaging method. RESULTS: The most significantly independent factors for obesity were delivery method (cesarean section vs. vaginal delivery, β = 0.56, p = 0.007), birth weight (>3500 to <4000 g vs. 2500-3500 g, β = 0.52, p = 0.035; ≥4000 g vs. 2500-3500 g, β = 1.06, p = 0.015), night sleep duration (<8 h/day vs. ≥8 h/day, β = 0.99, p < 0.0001), and BDNF Val66Met polymorphism (AA and GG vs. AG, β = 0.38, p = 0.039). CONCLUSIONS: The study suggested the significant association of delivery method, birth weight, night sleep duration, and BDNF Val66Met polymorphism, with obesity in Vietnamese primary school children. SN - 2153-2176 UR - https://www.unboundmedicine.com/medline/citation/28471701/The_Brain_Derived_Neurotrophic_Factor_Val66Met_Polymorphism_Delivery_Method_Birth_Weight_and_Night_Sleep_Duration_as_Determinants_of_Obesity_in_Vietnamese_Children_of_Primary_School_Age_ L2 - https://www.liebertpub.com/doi/full/10.1089/chi.2017.0007?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -