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Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.
J Diet Suppl. 2017 Nov 02; 14(6):599-612.JD

Abstract

OBJECTIVES

Cognitive decline is often associated with the aging process. Ashwagandha (Withania somnifera (L.) Dunal) has long been used in the traditional Ayurvedic system of medicine to enhance memory and improve cognition.

AIM

This pilot study was designed to evaluate the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) in improving memory and cognitive functioning in adults with mild cognitive impairment (MCI).

METHODS

A prospective, randomized, double-blind, placebo-controlled study was conducted in 50 adults. Subjects were treated with either ashwagandha-root extract (300 mg twice daily) or placebo for eight weeks.

RESULTS

After eight weeks of study, the ashwagandha treatment group demonstrated significant improvements compared with the placebo group in both immediate and general memory, as evidenced by Wechsler Memory Scale III subtest scores for logical memory I (p = 0.007), verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), logical memory II (p = 0.006), verbal paired associates II (p = 0.031), faces II (p = 0.014), and family pictures II (p = 0.006). The treatment group also demonstrated significantly greater improvement in executive function, sustained attention, and information-processing speed as indicated by scores on the Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009).

CONCLUSIONS

Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed.

Authors+Show Affiliations

a Indian Red Cross Society , Red Cross House , Pune , India.b Department of Pharmaceutical Technology , NSHM Knowledge Campus , Kolkata , India.b Department of Pharmaceutical Technology , NSHM Knowledge Campus , Kolkata , India.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28471731

Citation

Choudhary, Dnyanraj, et al. "Efficacy and Safety of Ashwagandha (Withania Somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions." Journal of Dietary Supplements, vol. 14, no. 6, 2017, pp. 599-612.
Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. J Diet Suppl. 2017;14(6):599-612.
Choudhary, D., Bhattacharyya, S., & Bose, S. (2017). Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. Journal of Dietary Supplements, 14(6), 599-612. https://doi.org/10.1080/19390211.2017.1284970
Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania Somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. J Diet Suppl. 2017 Nov 2;14(6):599-612. PubMed PMID: 28471731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. AU - Choudhary,Dnyanraj, AU - Bhattacharyya,Sauvik, AU - Bose,Sekhar, Y1 - 2017/02/21/ PY - 2017/5/5/entrez PY - 2017/5/5/pubmed PY - 2018/3/14/medline KW - Withania somnifera (L.) Dunal KW - ashwagandha KW - cognition KW - efficacy KW - memory KW - safety SP - 599 EP - 612 JF - Journal of dietary supplements JO - J Diet Suppl VL - 14 IS - 6 N2 - OBJECTIVES: Cognitive decline is often associated with the aging process. Ashwagandha (Withania somnifera (L.) Dunal) has long been used in the traditional Ayurvedic system of medicine to enhance memory and improve cognition. AIM: This pilot study was designed to evaluate the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) in improving memory and cognitive functioning in adults with mild cognitive impairment (MCI). METHODS: A prospective, randomized, double-blind, placebo-controlled study was conducted in 50 adults. Subjects were treated with either ashwagandha-root extract (300 mg twice daily) or placebo for eight weeks. RESULTS: After eight weeks of study, the ashwagandha treatment group demonstrated significant improvements compared with the placebo group in both immediate and general memory, as evidenced by Wechsler Memory Scale III subtest scores for logical memory I (p = 0.007), verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), logical memory II (p = 0.006), verbal paired associates II (p = 0.031), faces II (p = 0.014), and family pictures II (p = 0.006). The treatment group also demonstrated significantly greater improvement in executive function, sustained attention, and information-processing speed as indicated by scores on the Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009). CONCLUSIONS: Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed. SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/28471731/Efficacy_and_Safety_of_Ashwagandha__Withania_somnifera__L___Dunal__Root_Extract_in_Improving_Memory_and_Cognitive_Functions_ L2 - https://www.tandfonline.com/doi/full/10.1080/19390211.2017.1284970 DB - PRIME DP - Unbound Medicine ER -