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Etiologies of acute demyelinating optic neuritis: an observational study of 110 patients.
Eur J Neurol 2017; 24(6):875-879EJ

Abstract

BACKGROUND AND PURPOSE

New criteria for the diagnosis of multiple sclerosis (MS) and discovery of myelin oligodendrocyte glycoprotein (MOG) or aquaporin-4 (AQP4) antibodies (Abs) have changed the management of optic neuritis (ON). Our aim was to specify, in view of these recent advances, the etiologies of acute demyelinating ON for consecutive patients.

METHODS

Retrospective database analysis was undertaken of consecutive adult patients with acute ON admitted from 1 December 2014 to 31 January 2016. Diagnosis of MS was made according to the 2010 McDonald criteria. Patients with Abs to AQP4 or MOG were classified as ON-AQP4 and ON-MOG, respectively. Patients who did not fulfill the diagnostic criteria and were negative for AQP4 and MOG Ab tests were classified as having idiopathic ON.

RESULTS

Of 110 patients assessed, 78 had ON related to MS (70.9%). All patients without MS were tested for AQP4 and MOG Abs: 11 had MOG Ab (10%), 5 had AQP4 Ab (4.5%) and 16 were considered as having idiopathic ON (14.5%). Presence of intrathecal IgG oligoclonal bands was strongly associated with MS (mean, 88.4% vs. 34.4% in patients without MS; after Bonferroni correction, P < 0.0001).

CONCLUSIONS

Optic neuritis related to MOG Ab was the second cause identified of demyelinating ON in our center. Idiopathic ON was as frequent as both ON-AQP4 and ON-MOG combined.

Authors+Show Affiliations

Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neuro-Ophthalmolology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.Department of Neuro-Ophthalmolology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28477397

Citation

Deschamps, R, et al. "Etiologies of Acute Demyelinating Optic Neuritis: an Observational Study of 110 Patients." European Journal of Neurology, vol. 24, no. 6, 2017, pp. 875-879.
Deschamps R, Lecler A, Lamirel C, et al. Etiologies of acute demyelinating optic neuritis: an observational study of 110 patients. Eur J Neurol. 2017;24(6):875-879.
Deschamps, R., Lecler, A., Lamirel, C., Aboab, J., Gueguen, A., Bensa, C., ... Gout, O. (2017). Etiologies of acute demyelinating optic neuritis: an observational study of 110 patients. European Journal of Neurology, 24(6), pp. 875-879. doi:10.1111/ene.13315.
Deschamps R, et al. Etiologies of Acute Demyelinating Optic Neuritis: an Observational Study of 110 Patients. Eur J Neurol. 2017;24(6):875-879. PubMed PMID: 28477397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiologies of acute demyelinating optic neuritis: an observational study of 110 patients. AU - Deschamps,R, AU - Lecler,A, AU - Lamirel,C, AU - Aboab,J, AU - Gueguen,A, AU - Bensa,C, AU - Vignal,C, AU - Gout,O, Y1 - 2017/05/06/ PY - 2016/12/05/received PY - 2017/04/03/accepted PY - 2017/5/10/pubmed PY - 2018/2/13/medline PY - 2017/5/7/entrez KW - anti-aquaporin-4 KW - multiple sclerosis KW - myelin oligodendrocyte glycoprotein KW - neuromyelitis optica KW - optic neuritis SP - 875 EP - 879 JF - European journal of neurology JO - Eur. J. Neurol. VL - 24 IS - 6 N2 - BACKGROUND AND PURPOSE: New criteria for the diagnosis of multiple sclerosis (MS) and discovery of myelin oligodendrocyte glycoprotein (MOG) or aquaporin-4 (AQP4) antibodies (Abs) have changed the management of optic neuritis (ON). Our aim was to specify, in view of these recent advances, the etiologies of acute demyelinating ON for consecutive patients. METHODS: Retrospective database analysis was undertaken of consecutive adult patients with acute ON admitted from 1 December 2014 to 31 January 2016. Diagnosis of MS was made according to the 2010 McDonald criteria. Patients with Abs to AQP4 or MOG were classified as ON-AQP4 and ON-MOG, respectively. Patients who did not fulfill the diagnostic criteria and were negative for AQP4 and MOG Ab tests were classified as having idiopathic ON. RESULTS: Of 110 patients assessed, 78 had ON related to MS (70.9%). All patients without MS were tested for AQP4 and MOG Abs: 11 had MOG Ab (10%), 5 had AQP4 Ab (4.5%) and 16 were considered as having idiopathic ON (14.5%). Presence of intrathecal IgG oligoclonal bands was strongly associated with MS (mean, 88.4% vs. 34.4% in patients without MS; after Bonferroni correction, P < 0.0001). CONCLUSIONS: Optic neuritis related to MOG Ab was the second cause identified of demyelinating ON in our center. Idiopathic ON was as frequent as both ON-AQP4 and ON-MOG combined. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/28477397/Etiologies_of_acute_demyelinating_optic_neuritis:_an_observational_study_of_110_patients_ L2 - https://doi.org/10.1111/ene.13315 DB - PRIME DP - Unbound Medicine ER -