Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength.J Pharm Sci. 2017 08; 106(8):2060-2067.JP
Abstract
Punch sticking is a complex phenomenon influenced primarily by particle size, tooling surface roughness, tooling design, and tooling construction material. When particle and environmental factors are controlled, compaction pressure has a distinct effect on punch sticking behavior for a given active pharmaceutical ingredient (API). This research focuses on the effect of compaction pressure on punch sticking using 5 compounds with different sticking propensities. The results collectively show that sticking tends to be more problematic under higher compaction pressures and for more ductile compounds. This is attributed to the greater punch surface coverage by the API and the stronger cohesion of API to the existing API layer on the punch.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
28478129
Citation
Paul, Shubhajit, et al. "Dependence of Punch Sticking On Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength." Journal of Pharmaceutical Sciences, vol. 106, no. 8, 2017, pp. 2060-2067.
Paul S, Wang K, Taylor LJ, et al. Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength. J Pharm Sci. 2017;106(8):2060-2067.
Paul, S., Wang, K., Taylor, L. J., Murphy, B., Krzyzaniak, J., Dawson, N., Mullarney, M. P., Meenan, P., & Sun, C. C. (2017). Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength. Journal of Pharmaceutical Sciences, 106(8), 2060-2067. https://doi.org/10.1016/j.xphs.2017.04.059
Paul S, et al. Dependence of Punch Sticking On Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength. J Pharm Sci. 2017;106(8):2060-2067. PubMed PMID: 28478129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength.
AU - Paul,Shubhajit,
AU - Wang,Kunlin,
AU - Taylor,Lisa J,
AU - Murphy,Brendan,
AU - Krzyzaniak,Joseph,
AU - Dawson,Neil,
AU - Mullarney,Matthew P,
AU - Meenan,Paul,
AU - Sun,Changquan Calvin,
Y1 - 2017/05/04/
PY - 2017/01/31/received
PY - 2017/03/29/revised
PY - 2017/04/19/accepted
PY - 2017/5/10/pubmed
PY - 2018/5/10/medline
PY - 2017/5/8/entrez
KW - bonding strength
KW - compression
KW - plastic deformation
KW - pressure
KW - punch sticking
KW - surface area
SP - 2060
EP - 2067
JF - Journal of pharmaceutical sciences
JO - J Pharm Sci
VL - 106
IS - 8
N2 - Punch sticking is a complex phenomenon influenced primarily by particle size, tooling surface roughness, tooling design, and tooling construction material. When particle and environmental factors are controlled, compaction pressure has a distinct effect on punch sticking behavior for a given active pharmaceutical ingredient (API). This research focuses on the effect of compaction pressure on punch sticking using 5 compounds with different sticking propensities. The results collectively show that sticking tends to be more problematic under higher compaction pressures and for more ductile compounds. This is attributed to the greater punch surface coverage by the API and the stronger cohesion of API to the existing API layer on the punch.
SN - 1520-6017
UR - https://www.unboundmedicine.com/medline/citation/28478129/Dependence_of_Punch_Sticking_on_Compaction_Pressure_Roles_of_Particle_Deformability_and_Tablet_Tensile_Strength_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(17)30328-3
DB - PRIME
DP - Unbound Medicine
ER -