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Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength.
J Pharm Sci. 2017 08; 106(8):2060-2067.JP

Abstract

Punch sticking is a complex phenomenon influenced primarily by particle size, tooling surface roughness, tooling design, and tooling construction material. When particle and environmental factors are controlled, compaction pressure has a distinct effect on punch sticking behavior for a given active pharmaceutical ingredient (API). This research focuses on the effect of compaction pressure on punch sticking using 5 compounds with different sticking propensities. The results collectively show that sticking tends to be more problematic under higher compaction pressures and for more ductile compounds. This is attributed to the greater punch surface coverage by the API and the stronger cohesion of API to the existing API layer on the punch.

Authors+Show Affiliations

Department of Pharmaceutics, Pharmaceutical Materials Science and Engineering Laboratory, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455.Department of Pharmaceutics, Pharmaceutical Materials Science and Engineering Laboratory, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455.Pfizer Worldwide Research & Development, Sandwich, UK.Pfizer Worldwide Research & Development, Groton, Connecticut 06340.Pfizer Worldwide Research & Development, Groton, Connecticut 06340.Pfizer Worldwide Research & Development, Sandwich, UK.Pfizer Worldwide Research & Development, Groton, Connecticut 06340.Pfizer Worldwide Research & Development, Groton, Connecticut 06340.Department of Pharmaceutics, Pharmaceutical Materials Science and Engineering Laboratory, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455. Electronic address: sunx0053@umn.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28478129

Citation

Paul, Shubhajit, et al. "Dependence of Punch Sticking On Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength." Journal of Pharmaceutical Sciences, vol. 106, no. 8, 2017, pp. 2060-2067.
Paul S, Wang K, Taylor LJ, et al. Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength. J Pharm Sci. 2017;106(8):2060-2067.
Paul, S., Wang, K., Taylor, L. J., Murphy, B., Krzyzaniak, J., Dawson, N., Mullarney, M. P., Meenan, P., & Sun, C. C. (2017). Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength. Journal of Pharmaceutical Sciences, 106(8), 2060-2067. https://doi.org/10.1016/j.xphs.2017.04.059
Paul S, et al. Dependence of Punch Sticking On Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength. J Pharm Sci. 2017;106(8):2060-2067. PubMed PMID: 28478129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength. AU - Paul,Shubhajit, AU - Wang,Kunlin, AU - Taylor,Lisa J, AU - Murphy,Brendan, AU - Krzyzaniak,Joseph, AU - Dawson,Neil, AU - Mullarney,Matthew P, AU - Meenan,Paul, AU - Sun,Changquan Calvin, Y1 - 2017/05/04/ PY - 2017/01/31/received PY - 2017/03/29/revised PY - 2017/04/19/accepted PY - 2017/5/10/pubmed PY - 2018/5/10/medline PY - 2017/5/8/entrez KW - bonding strength KW - compression KW - plastic deformation KW - pressure KW - punch sticking KW - surface area SP - 2060 EP - 2067 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 106 IS - 8 N2 - Punch sticking is a complex phenomenon influenced primarily by particle size, tooling surface roughness, tooling design, and tooling construction material. When particle and environmental factors are controlled, compaction pressure has a distinct effect on punch sticking behavior for a given active pharmaceutical ingredient (API). This research focuses on the effect of compaction pressure on punch sticking using 5 compounds with different sticking propensities. The results collectively show that sticking tends to be more problematic under higher compaction pressures and for more ductile compounds. This is attributed to the greater punch surface coverage by the API and the stronger cohesion of API to the existing API layer on the punch. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/28478129/Dependence_of_Punch_Sticking_on_Compaction_Pressure_Roles_of_Particle_Deformability_and_Tablet_Tensile_Strength_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(17)30328-3 DB - PRIME DP - Unbound Medicine ER -