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Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease.
Molecules. 2017 May 08; 22(5)M

Abstract

We aimed to explore the roles of glycoproteins in the pathogenesis of chronic and latent Keshan disease (CKD and LKD), and screen the lectins as indicators of significant differences in glycoproteins of KD saliva and serum. Blood and saliva were collected from 50 CKD, 50 LKD patients and 54 normal individuals. Saliva and serum lectin microarrays and saliva and serum microarrays were used to screen and verify the differences in the levels of lectin among the three groups. In the male saliva lectin microarray, Solanum tuberosum (potato) lectin (STL) and other 9 lectins showed differences between CKD and normal; STL and other 9 lectins showed differences between LKD and normal; Aleuria aurantia lectin (AAL) and other 15 lectins showed differences between CKD and LKD. In the female saliva microarray, Griffonia (Bandeiraea) simplicifolia lectin I (GSL-I) and other 9 lectins showed differences between CKD and normal; STL and other 7 lectins showed differences between LKD and normal; Maackia amurensis lectin I (MAL-I) and Triticum vulgaris (WGA) showed difference between CKD and LKD. In the male serum lectin microarray, Psophocarpus tetragonolobus lectin I (PTL-I) and other 16 lectins showed differences between CKD and normal; Ulexeuropaeus agglutinin I (UEA-I) and other 9 lectins showed differences between LKD and normal; AAL and other 13 lectins showed differences between CKD and LKD. In the female serum lectin microarray, WGA and other 13 lectins showed differences between CKD and normal; Euonymus europaeus lectin (EEL) and other 6 lectins showed differences between LKD and normal; MAL-I and other 14 lectins showed differences between CKD and LKD. Carbohydrate chain GlcNAc and α-Gal may play crucial roles in the pathogenesis of KD. STL may be considered the diagnostic biomarker for male CKD and LKD, while WGA may be useful in distinguishing between the two stages. STL may be considered the diagnostic biomarker for female LKD.

Authors+Show Affiliations

School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. senwang2016@163.com.Office of Teaching Affairs, Xi'an University, Xi'an 710061, Shaanxi, China. xiaofandd@163.com.Key Laboratory of Hormones and Development (Ministry of Health), Key laboratory of metabolic disease (Tianjin), Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China. duduyu2016@126.com.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. wytlyr0411@stu.xjtu.edu.cn.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. dpr1212@stu.xjtu.edu.cn.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. tanwh@xjtu.edu.cn.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. mikko.lammi@umu.se. Department of Integrative Medical Biology, University of Umeå, Umeå 90187, Sweden. mikko.lammi@umu.se.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. guox@xjtu.edu.cn.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

28481304

Citation

Wang, Sen, et al. "Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease." Molecules (Basel, Switzerland), vol. 22, no. 5, 2017.
Wang S, Fan Z, Zhou B, et al. Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease. Molecules. 2017;22(5).
Wang, S., Fan, Z., Zhou, B., Wang, Y., Du, P., Tan, W., Lammi, M. J., & Guo, X. (2017). Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease. Molecules (Basel, Switzerland), 22(5). https://doi.org/10.3390/molecules22050746
Wang S, et al. Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease. Molecules. 2017 May 8;22(5) PubMed PMID: 28481304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease. AU - Wang,Sen, AU - Fan,Zheng, AU - Zhou,Bing, AU - Wang,Yingting, AU - Du,Peiru, AU - Tan,Wuhong, AU - Lammi,Mikko J, AU - Guo,Xiong, Y1 - 2017/05/08/ PY - 2017/03/27/received PY - 2017/04/29/revised PY - 2017/05/02/accepted PY - 2017/5/9/entrez PY - 2017/5/10/pubmed PY - 2018/2/21/medline KW - Keshan disease KW - biomarker KW - glycoprotein KW - lectin microarray KW - saliva KW - serum JF - Molecules (Basel, Switzerland) JO - Molecules VL - 22 IS - 5 N2 - We aimed to explore the roles of glycoproteins in the pathogenesis of chronic and latent Keshan disease (CKD and LKD), and screen the lectins as indicators of significant differences in glycoproteins of KD saliva and serum. Blood and saliva were collected from 50 CKD, 50 LKD patients and 54 normal individuals. Saliva and serum lectin microarrays and saliva and serum microarrays were used to screen and verify the differences in the levels of lectin among the three groups. In the male saliva lectin microarray, Solanum tuberosum (potato) lectin (STL) and other 9 lectins showed differences between CKD and normal; STL and other 9 lectins showed differences between LKD and normal; Aleuria aurantia lectin (AAL) and other 15 lectins showed differences between CKD and LKD. In the female saliva microarray, Griffonia (Bandeiraea) simplicifolia lectin I (GSL-I) and other 9 lectins showed differences between CKD and normal; STL and other 7 lectins showed differences between LKD and normal; Maackia amurensis lectin I (MAL-I) and Triticum vulgaris (WGA) showed difference between CKD and LKD. In the male serum lectin microarray, Psophocarpus tetragonolobus lectin I (PTL-I) and other 16 lectins showed differences between CKD and normal; Ulexeuropaeus agglutinin I (UEA-I) and other 9 lectins showed differences between LKD and normal; AAL and other 13 lectins showed differences between CKD and LKD. In the female serum lectin microarray, WGA and other 13 lectins showed differences between CKD and normal; Euonymus europaeus lectin (EEL) and other 6 lectins showed differences between LKD and normal; MAL-I and other 14 lectins showed differences between CKD and LKD. Carbohydrate chain GlcNAc and α-Gal may play crucial roles in the pathogenesis of KD. STL may be considered the diagnostic biomarker for male CKD and LKD, while WGA may be useful in distinguishing between the two stages. STL may be considered the diagnostic biomarker for female LKD. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/28481304/Roles_of_Glycoproteins_in_the_Diagnosis_and_Differential_Diagnosis_of_Chronic_and_Latent_Keshan_Disease_ L2 - http://www.mdpi.com/resolver?pii=molecules22050746 DB - PRIME DP - Unbound Medicine ER -