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Multicenter Study of Outcomes with Ceftazidime-Avibactam in Patients with Carbapenem-Resistant Enterobacteriaceae Infections.

Abstract

Ceftazidime-avibactam is a novel cephalosporin-beta-lactamase inhibitor combination that is active against many carbapenem-resistant Enterobacteriaceae (CRE). We describe a retrospective chart review for 60 patients who received ceftazidime-avibactam for a CRE infection. In-hospital mortality was 32%, 53% of patients had microbiological cure, and 65% had clinical success. In this severely ill population with CRE infections, ceftazidime-avibactam was an appropriate option.

Authors+Show Affiliations

Philadelphia College of Pharmacy, Philadelphia, Pennsylvania, USA.University of Maryland School of Pharmacy, Baltimore, Maryland, USA.St. Joseph's Regional Medical Center, Paterson, New Jersey, USA.Hahnemann University Hospital, Philadelphia, Pennsylvania, USA.HonorHealth John C. Lincoln Medical Center, Phoenix, Arizona, USA.Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.Hackensack University Medical Center, Hackensack, New Jersey, USA.IU Health University Hospital, Indianapolis, Indiana, USA.St. Joseph's Regional Medical Center, Paterson, New Jersey, USA.Christiana Hospital, Newark, Delaware, USA.Christiana Hospital, Newark, Delaware, USA.St. Joseph's Regional Medical Center, Paterson, New Jersey, USA.Temple University School of Pharmacy, Philadelphia, PA, USA jason.gallagher@temple.edu.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28483952

Citation

King, Madeline, et al. "Multicenter Study of Outcomes With Ceftazidime-Avibactam in Patients With Carbapenem-Resistant Enterobacteriaceae Infections." Antimicrobial Agents and Chemotherapy, vol. 61, no. 7, 2017.
King M, Heil E, Kuriakose S, et al. Multicenter Study of Outcomes with Ceftazidime-Avibactam in Patients with Carbapenem-Resistant Enterobacteriaceae Infections. Antimicrob Agents Chemother. 2017;61(7).
King, M., Heil, E., Kuriakose, S., Bias, T., Huang, V., El-Beyrouty, C., ... Gallagher, J. C. (2017). Multicenter Study of Outcomes with Ceftazidime-Avibactam in Patients with Carbapenem-Resistant Enterobacteriaceae Infections. Antimicrobial Agents and Chemotherapy, 61(7), doi:10.1128/AAC.00449-17.
King M, et al. Multicenter Study of Outcomes With Ceftazidime-Avibactam in Patients With Carbapenem-Resistant Enterobacteriaceae Infections. Antimicrob Agents Chemother. 2017;61(7) PubMed PMID: 28483952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multicenter Study of Outcomes with Ceftazidime-Avibactam in Patients with Carbapenem-Resistant Enterobacteriaceae Infections. AU - King,Madeline, AU - Heil,Emily, AU - Kuriakose,Safia, AU - Bias,Tiffany, AU - Huang,Vanthida, AU - El-Beyrouty,Claudine, AU - McCoy,Dorothy, AU - Hiles,Jon, AU - Richards,Lynette, AU - Gardner,Julianne, AU - Harrington,Nicole, AU - Biason,Kenneth, AU - Gallagher,Jason C, Y1 - 2017/06/27/ PY - 2017/03/02/received PY - 2017/04/28/accepted PY - 2017/5/10/pubmed PY - 2018/4/4/medline PY - 2017/5/10/entrez KW - antibiotic resistance KW - beta-lactamases KW - carbapenemase JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 61 IS - 7 N2 - Ceftazidime-avibactam is a novel cephalosporin-beta-lactamase inhibitor combination that is active against many carbapenem-resistant Enterobacteriaceae (CRE). We describe a retrospective chart review for 60 patients who received ceftazidime-avibactam for a CRE infection. In-hospital mortality was 32%, 53% of patients had microbiological cure, and 65% had clinical success. In this severely ill population with CRE infections, ceftazidime-avibactam was an appropriate option. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/28483952/Multicenter_Study_of_Outcomes_with_Ceftazidime_Avibactam_in_Patients_with_Carbapenem_Resistant_Enterobacteriaceae_Infections_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=28483952 DB - PRIME DP - Unbound Medicine ER -