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Evidence of a probable role for 25-hydroxyvitamin D in the regulation of human calcium metabolism.
J Bone Miner Res 1988; 3(5):489-95JB

Abstract

1,25-Dihydroxyvitamin D [1,25-(OH)2D] is the principal mediator of the biologic effects of vitamin D. We showed previously that obese white subjects have low serum vitamin D and 25-hydroxyvitamin D (25-OHD) with increased serum-immunoreactive parathyroid hormone (PTH) and 1,25-(OH)2D, low urinary calcium, and increased urinary cyclic adenosine 3',5'-monophosphate (cyclic AMP) compared with nonobese white individuals. To determine whether 25-OHD modulates calcium metabolism, the effects of 25-OHD3, 40-100 micrograms/day for 9 days, were compared in seven obese and seven nonobese white subjects who were between the ages of 20 and 34 years. Each of them was hospitalized on a metabolic ward and given a constant daily diet that contained 400 mg calcium, 900 mg phosphate, and 18 mEq magnesium. Whereas 25-OHD3 increased mean serum 25-OHD from 7 +/- 1 to 37 +/- 5 ng/ml (P less than 0.01) and urinary calcium from 102 +/- 18 to 146 +/- 17 mg/day (P less than 0.001) and decreased mean serum 1,25-(OH)2D from 40 +/- 2 to 28 +/- 2 pg/ml (P less than 0.01) and urinary cyclic AMP from 3.23 +/- 0.57 to 2.00 +/- 0.17 nM/dl GF (P less than 0.05), it did not change mean serum calcium, ionized calcium, phosphate, magnesium, immunoreactive PTH or urinary phosphate, or creatinine clearance in the obese subjects. In contrast, 25-OHD3 increased mean serum 25-OHD from 16 +/- 1 to 46 +/- 4 pg/ml (P less than 0.001) but did not alter mean serum 1,25-(OH)2D or urinary calcium or cyclic AMP in the nonobese subjects.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Veterans Administration Medical Center, Charleston, SC 29403.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2848397

Citation

Bell, N H., et al. "Evidence of a Probable Role for 25-hydroxyvitamin D in the Regulation of Human Calcium Metabolism." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 3, no. 5, 1988, pp. 489-95.
Bell NH, Epstein S, Shary J, et al. Evidence of a probable role for 25-hydroxyvitamin D in the regulation of human calcium metabolism. J Bone Miner Res. 1988;3(5):489-95.
Bell, N. H., Epstein, S., Shary, J., Greene, V., Oexmann, M. J., & Shaw, S. (1988). Evidence of a probable role for 25-hydroxyvitamin D in the regulation of human calcium metabolism. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 3(5), pp. 489-95.
Bell NH, et al. Evidence of a Probable Role for 25-hydroxyvitamin D in the Regulation of Human Calcium Metabolism. J Bone Miner Res. 1988;3(5):489-95. PubMed PMID: 2848397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of a probable role for 25-hydroxyvitamin D in the regulation of human calcium metabolism. AU - Bell,N H, AU - Epstein,S, AU - Shary,J, AU - Greene,V, AU - Oexmann,M J, AU - Shaw,S, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 489 EP - 95 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 3 IS - 5 N2 - 1,25-Dihydroxyvitamin D [1,25-(OH)2D] is the principal mediator of the biologic effects of vitamin D. We showed previously that obese white subjects have low serum vitamin D and 25-hydroxyvitamin D (25-OHD) with increased serum-immunoreactive parathyroid hormone (PTH) and 1,25-(OH)2D, low urinary calcium, and increased urinary cyclic adenosine 3',5'-monophosphate (cyclic AMP) compared with nonobese white individuals. To determine whether 25-OHD modulates calcium metabolism, the effects of 25-OHD3, 40-100 micrograms/day for 9 days, were compared in seven obese and seven nonobese white subjects who were between the ages of 20 and 34 years. Each of them was hospitalized on a metabolic ward and given a constant daily diet that contained 400 mg calcium, 900 mg phosphate, and 18 mEq magnesium. Whereas 25-OHD3 increased mean serum 25-OHD from 7 +/- 1 to 37 +/- 5 ng/ml (P less than 0.01) and urinary calcium from 102 +/- 18 to 146 +/- 17 mg/day (P less than 0.001) and decreased mean serum 1,25-(OH)2D from 40 +/- 2 to 28 +/- 2 pg/ml (P less than 0.01) and urinary cyclic AMP from 3.23 +/- 0.57 to 2.00 +/- 0.17 nM/dl GF (P less than 0.05), it did not change mean serum calcium, ionized calcium, phosphate, magnesium, immunoreactive PTH or urinary phosphate, or creatinine clearance in the obese subjects. In contrast, 25-OHD3 increased mean serum 25-OHD from 16 +/- 1 to 46 +/- 4 pg/ml (P less than 0.001) but did not alter mean serum 1,25-(OH)2D or urinary calcium or cyclic AMP in the nonobese subjects.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/2848397/Evidence_of_a_probable_role_for_25_hydroxyvitamin_D_in_the_regulation_of_human_calcium_metabolism_ L2 - https://doi.org/10.1002/jbmr.5650030503 DB - PRIME DP - Unbound Medicine ER -