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Can preoperative and postoperative CA19-9 levels predict survival and early recurrence in patients with resectable hilar cholangiocarcinoma?
Oncotarget. 2017 Jul 11; 8(28):45335-45344.O

Abstract

BACKGROUND

To investigate the predictive values of preoperative and postoperative serum CA19-9 levels on survival and other prognostic factors including early recurrence in patients with resectable hilar cholangiocarcinoma.

RESULTS

In univariate analysis, increased preoperative and postoperative CA19-9 levels in the light of different cut-off points (37, 100, 150, 200, 400, 1000 U/ml) were significantly associated with poor survival outcomes, of which the cut-off point of 150 U/ml showed the strongest predictive value (both P < 0.001). Preoperative to postoperative increase in CA19-9 level was also correlated with poor survival outcome (P < 0.001). In multivariate analysis, preoperative CA19-9 level > 150 U/ml was significantly associated with lymph node metastasis (OR = 3.471, 95% CI 1.216-9.905; P = 0.020) and early recurrence (OR = 8.280, 95% CI 2.391-28.674; P = 0.001). Meanwhile, postoperative CA19-9 level > 150 U/ml was also correlated with early recurrence (OR = 4.006, 95% CI 1.107-14.459; P = 0.034).

MATERIALS AND METHODS

Ninety-eight patients who had undergone curative surgery for hilar cholangiocarcinoma between 1995 and 2014 in our institution were selected for the study. The correlations of preoperative and postoperative serum CA19-9 levels on the basis of different cut-off points with survival and various tumor factors were retrospectively analyzed with univariate and multivariate methods.

CONCLUSIONS

In patients with resectable hilar cholangiocarcinoma, serum CA19-9 predict survival and early recurrence. Patients with increased preoperative and postoperative CA19-9 levels have poor survival outcomes and higher tendency of early recurrence.

Authors+Show Affiliations

Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. Department of General Surgery, Gandaki Medical College, Pokhara, Nepal.Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28484084

Citation

Wang, Jun-Ke, et al. "Can Preoperative and Postoperative CA19-9 Levels Predict Survival and Early Recurrence in Patients With Resectable Hilar Cholangiocarcinoma?" Oncotarget, vol. 8, no. 28, 2017, pp. 45335-45344.
Wang JK, Hu HJ, Shrestha A, et al. Can preoperative and postoperative CA19-9 levels predict survival and early recurrence in patients with resectable hilar cholangiocarcinoma? Oncotarget. 2017;8(28):45335-45344.
Wang, J. K., Hu, H. J., Shrestha, A., Ma, W. J., Yang, Q., Liu, F., Cheng, N. S., & Li, F. Y. (2017). Can preoperative and postoperative CA19-9 levels predict survival and early recurrence in patients with resectable hilar cholangiocarcinoma? Oncotarget, 8(28), 45335-45344. https://doi.org/10.18632/oncotarget.17336
Wang JK, et al. Can Preoperative and Postoperative CA19-9 Levels Predict Survival and Early Recurrence in Patients With Resectable Hilar Cholangiocarcinoma. Oncotarget. 2017 Jul 11;8(28):45335-45344. PubMed PMID: 28484084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can preoperative and postoperative CA19-9 levels predict survival and early recurrence in patients with resectable hilar cholangiocarcinoma? AU - Wang,Jun-Ke, AU - Hu,Hai-Jie, AU - Shrestha,Anuj, AU - Ma,Wen-Jie, AU - Yang,Qin, AU - Liu,Fei, AU - Cheng,Nan-Sheng, AU - Li,Fu-Yu, PY - 2016/10/07/received PY - 2017/04/11/accepted PY - 2017/5/10/pubmed PY - 2018/4/12/medline PY - 2017/5/10/entrez KW - CA19-9 KW - early recurrence KW - hilar cholangiocarcinoma KW - prognosis SP - 45335 EP - 45344 JF - Oncotarget JO - Oncotarget VL - 8 IS - 28 N2 - BACKGROUND: To investigate the predictive values of preoperative and postoperative serum CA19-9 levels on survival and other prognostic factors including early recurrence in patients with resectable hilar cholangiocarcinoma. RESULTS: In univariate analysis, increased preoperative and postoperative CA19-9 levels in the light of different cut-off points (37, 100, 150, 200, 400, 1000 U/ml) were significantly associated with poor survival outcomes, of which the cut-off point of 150 U/ml showed the strongest predictive value (both P < 0.001). Preoperative to postoperative increase in CA19-9 level was also correlated with poor survival outcome (P < 0.001). In multivariate analysis, preoperative CA19-9 level > 150 U/ml was significantly associated with lymph node metastasis (OR = 3.471, 95% CI 1.216-9.905; P = 0.020) and early recurrence (OR = 8.280, 95% CI 2.391-28.674; P = 0.001). Meanwhile, postoperative CA19-9 level > 150 U/ml was also correlated with early recurrence (OR = 4.006, 95% CI 1.107-14.459; P = 0.034). MATERIALS AND METHODS: Ninety-eight patients who had undergone curative surgery for hilar cholangiocarcinoma between 1995 and 2014 in our institution were selected for the study. The correlations of preoperative and postoperative serum CA19-9 levels on the basis of different cut-off points with survival and various tumor factors were retrospectively analyzed with univariate and multivariate methods. CONCLUSIONS: In patients with resectable hilar cholangiocarcinoma, serum CA19-9 predict survival and early recurrence. Patients with increased preoperative and postoperative CA19-9 levels have poor survival outcomes and higher tendency of early recurrence. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/28484084/Can_preoperative_and_postoperative_CA19_9_levels_predict_survival_and_early_recurrence_in_patients_with_resectable_hilar_cholangiocarcinoma DB - PRIME DP - Unbound Medicine ER -