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Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC).
Gynecol Endocrinol. 2017 Dec; 33(12):958-962.GE

Abstract

This observational study was conducted in healthy premenopausal women, who presented themselves for contraceptive advice at the outpatient Family Planning Clinics of the Department of Obstetrics and Gynecology of the University of Cagliari, Hospital-University of Cagliari (Italy). After a screening period of three menstrual cycles, 48 women without contraindications to estroprogestin contraceptives (OCs) were included in the study. The primary purposes of the study were to evaluate whether a 12-month-treatment with the combined OC containing micronized estradiol (1.5 mg, E2) plus nomegestrol acetate (2.5 mg, NOMAC) (E2/NOMAC) interfere on anthropometric indices (AI), body composition (BC) and psychological status (PS). In subjects with dysmenorrhea (#36), its intensity was evaluated using the visuo analogic scale (VAS), both before and during the 12-month-treatment with E2/NOMAC. E2/NOMAC did not modify neither AI nor BC in the 40 subjects who concluded the study. The PS and the VAS of dysmenorrhea were significantly (p < 0.0001) improved from the first cycle of treatment and throughout the E2/NOMAC treatment in comparison with basal values. The study suggests that E2/NOMAC is devoid of negative effects on AI and BC, with additional benefits on PS and dysmenorrhea.

Authors+Show Affiliations

a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.a Department of Surgical Sciences , University of Cagliari , Cagliari , Italy and. b Department of Obstetrics and Gynecology at the University Hospital of Cagliari (AOUCA) , Cagliari , Italy.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28485628

Citation

Neri, Manuela, et al. "Body Composition and Psychological Improvement in Healthy Premenopausal Women Assuming the Oral Contraceptive Containing Micronized Estradiol (E2) and Nomegestrol Acetate (NOMAC)." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 33, no. 12, 2017, pp. 958-962.
Neri M, Malune ME, Corda V, et al. Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC). Gynecol Endocrinol. 2017;33(12):958-962.
Neri, M., Malune, M. E., Corda, V., Piras, B., Zedda, P., Pilloni, M., Orani, M. P., Vallerino, V., Melis, G. B., & Paoletti, A. M. (2017). Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC). Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 33(12), 958-962. https://doi.org/10.1080/09513590.2017.1322574
Neri M, et al. Body Composition and Psychological Improvement in Healthy Premenopausal Women Assuming the Oral Contraceptive Containing Micronized Estradiol (E2) and Nomegestrol Acetate (NOMAC). Gynecol Endocrinol. 2017;33(12):958-962. PubMed PMID: 28485628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC). AU - Neri,Manuela, AU - Malune,Maria Elena, AU - Corda,Valentina, AU - Piras,Bruno, AU - Zedda,Pierina, AU - Pilloni,Monica, AU - Orani,Maria Paola, AU - Vallerino,Valerio, AU - Melis,Gian Benedetto, AU - Paoletti,Anna Maria, Y1 - 2017/05/09/ PY - 2017/5/10/pubmed PY - 2018/7/10/medline PY - 2017/5/10/entrez KW - Body composition KW - dysmenorrhea KW - hormonal contraception KW - micronized estradiol KW - multifrequency bioelectrical impedance KW - nomegestrol acetate KW - psychological status SP - 958 EP - 962 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 33 IS - 12 N2 - This observational study was conducted in healthy premenopausal women, who presented themselves for contraceptive advice at the outpatient Family Planning Clinics of the Department of Obstetrics and Gynecology of the University of Cagliari, Hospital-University of Cagliari (Italy). After a screening period of three menstrual cycles, 48 women without contraindications to estroprogestin contraceptives (OCs) were included in the study. The primary purposes of the study were to evaluate whether a 12-month-treatment with the combined OC containing micronized estradiol (1.5 mg, E2) plus nomegestrol acetate (2.5 mg, NOMAC) (E2/NOMAC) interfere on anthropometric indices (AI), body composition (BC) and psychological status (PS). In subjects with dysmenorrhea (#36), its intensity was evaluated using the visuo analogic scale (VAS), both before and during the 12-month-treatment with E2/NOMAC. E2/NOMAC did not modify neither AI nor BC in the 40 subjects who concluded the study. The PS and the VAS of dysmenorrhea were significantly (p < 0.0001) improved from the first cycle of treatment and throughout the E2/NOMAC treatment in comparison with basal values. The study suggests that E2/NOMAC is devoid of negative effects on AI and BC, with additional benefits on PS and dysmenorrhea. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/28485628/Body_composition_and_psychological_improvement_in_healthy_premenopausal_women_assuming_the_oral_contraceptive_containing_micronized_estradiol__E2__and_nomegestrol_acetate__NOMAC__ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590.2017.1322574 DB - PRIME DP - Unbound Medicine ER -