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Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway.
Elife. 2017 05 09; 6E

Abstract

Although combinatorial regulation is a common feature in gene regulatory networks, how it evolves and affects network structure and function is not well understood. In S. cerevisiae, the phosphate starvation (PHO) responsive transcription factors Pho4 and Pho2 are required for gene induction and survival during phosphate starvation. In the related human commensal C. glabrata, Pho4 is required but Pho2 is dispensable for survival in phosphate starvation and is only partially required for inducing PHO genes. Phylogenetic survey suggests that reduced dependence on Pho2 evolved in C. glabrata and closely related species. In S. cerevisiae, less Pho2-dependent Pho4 orthologs induce more genes. In C. glabrata, its Pho4 binds to more locations and induces three times as many genes as Pho4 in S. cerevisiae does. Our work shows how evolution of combinatorial regulation allows for rapid expansion of a gene regulatory network's targets, possibly extending its physiological functions.

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Authors+Show Affiliations

He BZ
Faculty of Arts and Sciences Center for Systems Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, United States.
Zhou X
Faculty of Arts and Sciences Center for Systems Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, United States.
O'Shea EK
Faculty of Arts and Sciences Center for Systems Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, United States. Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States.

MeSH

Candida glabrataEvolution, MolecularGene Expression Regulation, FungalGene Regulatory NetworksMicrobial ViabilityPhosphatesPhylogenySaccharomyces cerevisiaeTranscription Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28485712

Citation

He, Bin Z., et al. "Evolution of Reduced Co-activator Dependence Led to Target Expansion of a Starvation Response Pathway." ELife, vol. 6, 2017.
He BZ, Zhou X, O'Shea EK. Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway. Elife. 2017;6.
He, B. Z., Zhou, X., & O'Shea, E. K. (2017). Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway. ELife, 6. https://doi.org/10.7554/eLife.25157
He BZ, Zhou X, O'Shea EK. Evolution of Reduced Co-activator Dependence Led to Target Expansion of a Starvation Response Pathway. Elife. 2017 05 9;6 PubMed PMID: 28485712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway. AU - He,Bin Z, AU - Zhou,Xu, AU - O'Shea,Erin K, Y1 - 2017/05/09/ PY - 2017/01/15/received PY - 2017/04/29/accepted PY - 2017/5/10/pubmed PY - 2018/2/13/medline PY - 2017/5/10/entrez KW - C. glabrata KW - Hemiascomycetes KW - S. cerevisiae KW - evolution of gene regulatory network KW - evolutionary biology KW - genomics KW - infectious disease KW - microbiology KW - other Hemiascomycete yeast species KW - phosphate starvation response JF - eLife JO - Elife VL - 6 N2 - Although combinatorial regulation is a common feature in gene regulatory networks, how it evolves and affects network structure and function is not well understood. In S. cerevisiae, the phosphate starvation (PHO) responsive transcription factors Pho4 and Pho2 are required for gene induction and survival during phosphate starvation. In the related human commensal C. glabrata, Pho4 is required but Pho2 is dispensable for survival in phosphate starvation and is only partially required for inducing PHO genes. Phylogenetic survey suggests that reduced dependence on Pho2 evolved in C. glabrata and closely related species. In S. cerevisiae, less Pho2-dependent Pho4 orthologs induce more genes. In C. glabrata, its Pho4 binds to more locations and induces three times as many genes as Pho4 in S. cerevisiae does. Our work shows how evolution of combinatorial regulation allows for rapid expansion of a gene regulatory network's targets, possibly extending its physiological functions. SN - 2050-084X UR - https://www.unboundmedicine.com/medline/citation/28485712/Evolution_of_reduced_co_activator_dependence_led_to_target_expansion_of_a_starvation_response_pathway_ L2 - https://doi.org/10.7554/eLife.25157 DB - PRIME DP - Unbound Medicine ER -