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Stimulation of the L2-L3 Dorsal Root Ganglia Induces Effective Pain Relief in the Low Back.
Pain Pract. 2018 02; 18(2):205-213.PP

Abstract

INTRODUCTION

Chronic low back pain affects millions of people worldwide and can arise through a variety of clinical origins. In the case of failed back surgery syndrome (FBSS), previous surgical procedures can contribute to low back pain that is often unresponsive to intervention. Although spinal cord stimulation (SCS) can be an effective treatment modality, it does not provide sufficient pain relief for some intractable cases. Recently, alternative neuromodulation options have been developed, including dorsal root ganglion (DRG) stimulation. The objective of this report is to further investigate these clinical observations.

METHODS

Twelve patients with significant chronic discogenic low back pain due to FBSS were included. All subjects underwent implantation of DRG stimulation systems that had at least 1 lead placed at L2 or L3. Subjects' pain ratings, mood, and quality of life were tracked prospectively for up to 12 months.

RESULTS

More than half of subjects reported 50% or better pain relief in the low back, and the average low back pain relief was 45.5% at 12 months. Concomitant reductions in overall pain, leg pain, pain interference, mood, and quality of life were also found.

DISCUSSION

For the studied population, DRG stimulation at the L2-L3 levels was effective at relieving low back pain. These reductions in pain were associated with improvements in quality of life. Thus, DRG stimulation at these levels may be effective for low back pain by recruiting both segmental and nonsegmental neural pathways that are not otherwise accessible via traditional SCS.

Authors+Show Affiliations

Erasmus University, Rotterdam, Maastricht, The Netherlands.Maastricht University Medical Centre, Maastricht, The Netherlands.Abbott Laboratories, Sunnyvale, California, U.S.A.Abbott Laboratories, Sunnyvale, California, U.S.A.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28486758

Citation

Huygen, Frank, et al. "Stimulation of the L2-L3 Dorsal Root Ganglia Induces Effective Pain Relief in the Low Back." Pain Practice : the Official Journal of World Institute of Pain, vol. 18, no. 2, 2018, pp. 205-213.
Huygen F, Liem L, Cusack W, et al. Stimulation of the L2-L3 Dorsal Root Ganglia Induces Effective Pain Relief in the Low Back. Pain Pract. 2018;18(2):205-213.
Huygen, F., Liem, L., Cusack, W., & Kramer, J. (2018). Stimulation of the L2-L3 Dorsal Root Ganglia Induces Effective Pain Relief in the Low Back. Pain Practice : the Official Journal of World Institute of Pain, 18(2), 205-213. https://doi.org/10.1111/papr.12591
Huygen F, et al. Stimulation of the L2-L3 Dorsal Root Ganglia Induces Effective Pain Relief in the Low Back. Pain Pract. 2018;18(2):205-213. PubMed PMID: 28486758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stimulation of the L2-L3 Dorsal Root Ganglia Induces Effective Pain Relief in the Low Back. AU - Huygen,Frank, AU - Liem,Liong, AU - Cusack,William, AU - Kramer,Jeffery, Y1 - 2017/12/06/ PY - 2017/02/13/received PY - 2017/03/22/revised PY - 2017/03/28/accepted PY - 2017/5/10/pubmed PY - 2018/12/18/medline PY - 2017/5/10/entrez KW - back pain KW - chronic pain KW - dorsal root ganglion stimulation KW - failed back surgery syndrome KW - neuromodulation KW - neuropathic pain KW - spinal cord stimulation SP - 205 EP - 213 JF - Pain practice : the official journal of World Institute of Pain JO - Pain Pract VL - 18 IS - 2 N2 - INTRODUCTION: Chronic low back pain affects millions of people worldwide and can arise through a variety of clinical origins. In the case of failed back surgery syndrome (FBSS), previous surgical procedures can contribute to low back pain that is often unresponsive to intervention. Although spinal cord stimulation (SCS) can be an effective treatment modality, it does not provide sufficient pain relief for some intractable cases. Recently, alternative neuromodulation options have been developed, including dorsal root ganglion (DRG) stimulation. The objective of this report is to further investigate these clinical observations. METHODS: Twelve patients with significant chronic discogenic low back pain due to FBSS were included. All subjects underwent implantation of DRG stimulation systems that had at least 1 lead placed at L2 or L3. Subjects' pain ratings, mood, and quality of life were tracked prospectively for up to 12 months. RESULTS: More than half of subjects reported 50% or better pain relief in the low back, and the average low back pain relief was 45.5% at 12 months. Concomitant reductions in overall pain, leg pain, pain interference, mood, and quality of life were also found. DISCUSSION: For the studied population, DRG stimulation at the L2-L3 levels was effective at relieving low back pain. These reductions in pain were associated with improvements in quality of life. Thus, DRG stimulation at these levels may be effective for low back pain by recruiting both segmental and nonsegmental neural pathways that are not otherwise accessible via traditional SCS. SN - 1533-2500 UR - https://www.unboundmedicine.com/medline/citation/28486758/Stimulation_of_the_L2_L3_Dorsal_Root_Ganglia_Induces_Effective_Pain_Relief_in_the_Low_Back_ L2 - https://doi.org/10.1111/papr.12591 DB - PRIME DP - Unbound Medicine ER -