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Adaptation to dietary conditions by trehalose metabolism in Drosophila.
Sci Rep. 2017 05 09; 7(1):1619.SR

Abstract

Trehalose is a non-reducing disaccharide that serves as the main sugar component of haemolymph in insects. Trehalose hydrolysis enzyme, called trehalase, is highly conserved from bacteria to humans. However, our understanding of the physiological role of trehalase remains incomplete. Here, we analyze the phenotypes of several Trehalase (Treh) loss-of-function alleles in a comparative manner in Drosophila. The previously reported mutant phenotype of Treh affecting neuroepithelial stem cell maintenance and differentiation in the optic lobe is caused by second-site alleles in addition to Treh. We further report that the survival rate of Treh null mutants is significantly influenced by dietary conditions. Treh mutant larvae are lethal not only on a low-sugar diet but also under low-protein diet conditions. A reduction in adaptation ability under poor food conditions in Treh mutants is mainly caused by the overaccumulation of trehalose rather than the loss of Treh, because the additional loss of Tps1 mitigates the lethal effect of Treh mutants. These results demonstrate that proper trehalose metabolism plays a critical role in adaptation under various environmental conditions.

Authors+Show Affiliations

Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. t-nishimura@cdb.riken.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28487555

Citation

Yasugi, Tetsuo, et al. "Adaptation to Dietary Conditions By Trehalose Metabolism in Drosophila." Scientific Reports, vol. 7, no. 1, 2017, p. 1619.
Yasugi T, Yamada T, Nishimura T. Adaptation to dietary conditions by trehalose metabolism in Drosophila. Sci Rep. 2017;7(1):1619.
Yasugi, T., Yamada, T., & Nishimura, T. (2017). Adaptation to dietary conditions by trehalose metabolism in Drosophila. Scientific Reports, 7(1), 1619. https://doi.org/10.1038/s41598-017-01754-9
Yasugi T, Yamada T, Nishimura T. Adaptation to Dietary Conditions By Trehalose Metabolism in Drosophila. Sci Rep. 2017 05 9;7(1):1619. PubMed PMID: 28487555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adaptation to dietary conditions by trehalose metabolism in Drosophila. AU - Yasugi,Tetsuo, AU - Yamada,Takayuki, AU - Nishimura,Takashi, Y1 - 2017/05/09/ PY - 2017/02/13/received PY - 2017/04/03/accepted PY - 2017/5/11/entrez PY - 2017/5/11/pubmed PY - 2018/12/12/medline SP - 1619 EP - 1619 JF - Scientific reports JO - Sci Rep VL - 7 IS - 1 N2 - Trehalose is a non-reducing disaccharide that serves as the main sugar component of haemolymph in insects. Trehalose hydrolysis enzyme, called trehalase, is highly conserved from bacteria to humans. However, our understanding of the physiological role of trehalase remains incomplete. Here, we analyze the phenotypes of several Trehalase (Treh) loss-of-function alleles in a comparative manner in Drosophila. The previously reported mutant phenotype of Treh affecting neuroepithelial stem cell maintenance and differentiation in the optic lobe is caused by second-site alleles in addition to Treh. We further report that the survival rate of Treh null mutants is significantly influenced by dietary conditions. Treh mutant larvae are lethal not only on a low-sugar diet but also under low-protein diet conditions. A reduction in adaptation ability under poor food conditions in Treh mutants is mainly caused by the overaccumulation of trehalose rather than the loss of Treh, because the additional loss of Tps1 mitigates the lethal effect of Treh mutants. These results demonstrate that proper trehalose metabolism plays a critical role in adaptation under various environmental conditions. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28487555/Adaptation_to_dietary_conditions_by_trehalose_metabolism_in_Drosophila_ L2 - http://dx.doi.org/10.1038/s41598-017-01754-9 DB - PRIME DP - Unbound Medicine ER -