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Effect of diets rich in either saturated fat or n-6 polyunsaturated fatty acids and supplemented with long-chain n-3 polyunsaturated fatty acids on plasma lipoprotein profiles.
Eur J Clin Nutr 2017; 71(11):1297-1302EJ

Abstract

BACKGROUND/OBJECTIVES

Abnormalities in lipoprotein profiles (size, distribution and concentration) play an important role in the pathobiology of atherosclerosis and coronary artery disease. Dietary fat, among other factors, has been demonstrated to modulate lipoprotein profiles. We aimed to investigate if background dietary fat (saturated, SFA versus omega-6 polyunsaturated fatty acids, n-6PUFA) was a determinant of the effects of LCn-3PUFA supplementation on lipoprotein profiles.

SUBJECTS/METHODS

A randomized controlled clinical intervention trial in a parallel design was conducted. Healthy subjects (n=26) were supplemented with 400 mg eicosapentaenoic acid plus 2000 mg docosahexaenoic acid daily and randomized to consume diets rich in either SFA or n-6PUFA for a period of 6 weeks. Blood samples, collected at baseline and after 6 weeks of intervention, were assessed for plasma lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) determined using nuclear magnetic resonance spectroscopy.

RESULTS

Study participants receiving the SFA or the n-6PUFA enriched diets consumed similar percentage energy from fat (41 and 42% respectively, P=0.681). However, subjects on the SFA diet consumed 50% more energy as saturated fat and 77% less as linoleic acid than those consuming the n-6PUFA diet (P<0.001). The diets rich in SFA and n-6PUFA reduced the concentration of total very-low-density lipoprotein (VLDL) particles (P<0.001, both), and their subclasses and increased VLDL (P=0.042 and P=0.007, respectively) and LDL (P=0.030 and 0.027, respectively) particle size. In addition, plasma triglyceride concentration was significantly reduced by LCn-3PUFA supplementation irrespective of the dietary fat.

CONCLUSIONS

LCn-3PUFA modulated lipoprotein profiles in a similar fashion when supplemented in diets rich in either SFA or n-6PUFA.

Authors+Show Affiliations

Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia.Metabolomics Platform, Rovira i Virgili University, IISPV, Tarragona, Spain. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), C/ Monforte de Lemos 3-5, Madrid, Spain. Biosfer Teslab, Plaça Prim 10, 2on 5a, Reus, Spain.Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, The University of Newcastle, New Lambton, New South Wales, Australia.Metabolomics Platform, Rovira i Virgili University, IISPV, Tarragona, Spain. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), C/ Monforte de Lemos 3-5, Madrid, Spain.Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28488685

Citation

Dias, C B., et al. "Effect of Diets Rich in Either Saturated Fat or N-6 Polyunsaturated Fatty Acids and Supplemented With Long-chain N-3 Polyunsaturated Fatty Acids On Plasma Lipoprotein Profiles." European Journal of Clinical Nutrition, vol. 71, no. 11, 2017, pp. 1297-1302.
Dias CB, Amigo N, Wood LG, et al. Effect of diets rich in either saturated fat or n-6 polyunsaturated fatty acids and supplemented with long-chain n-3 polyunsaturated fatty acids on plasma lipoprotein profiles. Eur J Clin Nutr. 2017;71(11):1297-1302.
Dias, C. B., Amigo, N., Wood, L. G., Correig, X., & Garg, M. L. (2017). Effect of diets rich in either saturated fat or n-6 polyunsaturated fatty acids and supplemented with long-chain n-3 polyunsaturated fatty acids on plasma lipoprotein profiles. European Journal of Clinical Nutrition, 71(11), pp. 1297-1302. doi:10.1038/ejcn.2017.56.
Dias CB, et al. Effect of Diets Rich in Either Saturated Fat or N-6 Polyunsaturated Fatty Acids and Supplemented With Long-chain N-3 Polyunsaturated Fatty Acids On Plasma Lipoprotein Profiles. Eur J Clin Nutr. 2017;71(11):1297-1302. PubMed PMID: 28488685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of diets rich in either saturated fat or n-6 polyunsaturated fatty acids and supplemented with long-chain n-3 polyunsaturated fatty acids on plasma lipoprotein profiles. AU - Dias,C B, AU - Amigo,N, AU - Wood,L G, AU - Correig,X, AU - Garg,M L, Y1 - 2017/05/10/ PY - 2016/12/11/received PY - 2017/02/26/revised PY - 2017/03/22/accepted PY - 2017/5/11/pubmed PY - 2018/6/14/medline PY - 2017/5/11/entrez SP - 1297 EP - 1302 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 71 IS - 11 N2 - BACKGROUND/OBJECTIVES: Abnormalities in lipoprotein profiles (size, distribution and concentration) play an important role in the pathobiology of atherosclerosis and coronary artery disease. Dietary fat, among other factors, has been demonstrated to modulate lipoprotein profiles. We aimed to investigate if background dietary fat (saturated, SFA versus omega-6 polyunsaturated fatty acids, n-6PUFA) was a determinant of the effects of LCn-3PUFA supplementation on lipoprotein profiles. SUBJECTS/METHODS: A randomized controlled clinical intervention trial in a parallel design was conducted. Healthy subjects (n=26) were supplemented with 400 mg eicosapentaenoic acid plus 2000 mg docosahexaenoic acid daily and randomized to consume diets rich in either SFA or n-6PUFA for a period of 6 weeks. Blood samples, collected at baseline and after 6 weeks of intervention, were assessed for plasma lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) determined using nuclear magnetic resonance spectroscopy. RESULTS: Study participants receiving the SFA or the n-6PUFA enriched diets consumed similar percentage energy from fat (41 and 42% respectively, P=0.681). However, subjects on the SFA diet consumed 50% more energy as saturated fat and 77% less as linoleic acid than those consuming the n-6PUFA diet (P<0.001). The diets rich in SFA and n-6PUFA reduced the concentration of total very-low-density lipoprotein (VLDL) particles (P<0.001, both), and their subclasses and increased VLDL (P=0.042 and P=0.007, respectively) and LDL (P=0.030 and 0.027, respectively) particle size. In addition, plasma triglyceride concentration was significantly reduced by LCn-3PUFA supplementation irrespective of the dietary fat. CONCLUSIONS: LCn-3PUFA modulated lipoprotein profiles in a similar fashion when supplemented in diets rich in either SFA or n-6PUFA. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/28488685/Effect_of_diets_rich_in_either_saturated_fat_or_n_6_polyunsaturated_fatty_acids_and_supplemented_with_long_chain_n_3_polyunsaturated_fatty_acids_on_plasma_lipoprotein_profiles_ L2 - http://dx.doi.org/10.1038/ejcn.2017.56 DB - PRIME DP - Unbound Medicine ER -