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Comparison of reversal with neostigmine of low-dose rocuronium vs. reversal with sugammadex of high-dose rocuronium for a short procedure.
Anaesthesia. 2017 10; 72(10):1185-1190.A

Abstract

Some short procedures require deep neuromuscular blockade, which needs to be reversed at the end of the procedure. Forty-four patients undergoing elective laryngeal micro-surgery were randomly allocated into two groups: rocuronium 0.45 mg.kg-1 with neostigmine (50 μg.kg-1 with glycopyrrolate 10 μg.kg-1) reversal (moderate block group) vs. rocuronium 0.90 mg.kg-1 with sugammadex (4 mg.kg-1) reversal (deep block group). The primary outcome was the intubating conditions during laryngoscopy secondary outcomes included recovery of neuromuscular block; conditions for tracheal intubation; satisfaction score as determined by the surgeon; onset of neuromuscular block; and postoperative sore throat. The onset of neuromuscular block was more rapid, and intubation conditions and ease of intra-operative laryngoscopy were more favourable, and the satisfaction score was lower in the moderate block group compared with the deep block group. No difference was found in the incidence of postoperative sore throat. In laryngeal micro-surgery, the use of rocuronium 0.9 mg.kg-1 with sugammadex for reversal was associated with better surgical conditions and a shorter recovery time than rocuronium 0.45 mg.kg-1 with neostigmine.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Sungnam, Korea.Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Sungnam, Korea. Deparment of Anesthesiology and Pain Medicine, Seoul National University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Sungnam, Korea.Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Sungnam, Korea.Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Sungnam, Korea.Department of Dental Anesthesiology, Seoul National University Dental Hospital, Seoul, Korea.Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University Bundang Hospital, Sungnam, Korea.Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University Bundang Hospital, Sungnam, Korea.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28493510

Citation

Choi, E S., et al. "Comparison of Reversal With Neostigmine of Low-dose Rocuronium Vs. Reversal With Sugammadex of High-dose Rocuronium for a Short Procedure." Anaesthesia, vol. 72, no. 10, 2017, pp. 1185-1190.
Choi ES, Oh AY, Koo BW, et al. Comparison of reversal with neostigmine of low-dose rocuronium vs. reversal with sugammadex of high-dose rocuronium for a short procedure. Anaesthesia. 2017;72(10):1185-1190.
Choi, E. S., Oh, A. Y., Koo, B. W., Hwang, J. W., Han, J. W., Seo, K. S., Ahn, S. H., & Jeong, W. J. (2017). Comparison of reversal with neostigmine of low-dose rocuronium vs. reversal with sugammadex of high-dose rocuronium for a short procedure. Anaesthesia, 72(10), 1185-1190. https://doi.org/10.1111/anae.13894
Choi ES, et al. Comparison of Reversal With Neostigmine of Low-dose Rocuronium Vs. Reversal With Sugammadex of High-dose Rocuronium for a Short Procedure. Anaesthesia. 2017;72(10):1185-1190. PubMed PMID: 28493510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of reversal with neostigmine of low-dose rocuronium vs. reversal with sugammadex of high-dose rocuronium for a short procedure. AU - Choi,E S, AU - Oh,A Y, AU - Koo,B W, AU - Hwang,J W, AU - Han,J W, AU - Seo,K S, AU - Ahn,S H, AU - Jeong,W J, Y1 - 2017/05/11/ PY - 2017/03/08/accepted PY - 2017/5/12/pubmed PY - 2019/2/26/medline PY - 2017/5/12/entrez KW - larynx KW - neostigmine KW - neuromuscular blockade KW - rocuronium KW - sugammadex SP - 1185 EP - 1190 JF - Anaesthesia JO - Anaesthesia VL - 72 IS - 10 N2 - Some short procedures require deep neuromuscular blockade, which needs to be reversed at the end of the procedure. Forty-four patients undergoing elective laryngeal micro-surgery were randomly allocated into two groups: rocuronium 0.45 mg.kg-1 with neostigmine (50 μg.kg-1 with glycopyrrolate 10 μg.kg-1) reversal (moderate block group) vs. rocuronium 0.90 mg.kg-1 with sugammadex (4 mg.kg-1) reversal (deep block group). The primary outcome was the intubating conditions during laryngoscopy secondary outcomes included recovery of neuromuscular block; conditions for tracheal intubation; satisfaction score as determined by the surgeon; onset of neuromuscular block; and postoperative sore throat. The onset of neuromuscular block was more rapid, and intubation conditions and ease of intra-operative laryngoscopy were more favourable, and the satisfaction score was lower in the moderate block group compared with the deep block group. No difference was found in the incidence of postoperative sore throat. In laryngeal micro-surgery, the use of rocuronium 0.9 mg.kg-1 with sugammadex for reversal was associated with better surgical conditions and a shorter recovery time than rocuronium 0.45 mg.kg-1 with neostigmine. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/28493510/Comparison_of_reversal_with_neostigmine_of_low_dose_rocuronium_vs__reversal_with_sugammadex_of_high_dose_rocuronium_for_a_short_procedure_ L2 - https://doi.org/10.1111/anae.13894 DB - PRIME DP - Unbound Medicine ER -