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Peripheral neuropathy associated with mitochondrial myopathy.
Aust Paediatr J. 1988; 24 Suppl 1:62-3.AP

Abstract

Twenty patients with mitochondrial myopathy were investigated for the presence of peripheral neuropathy. There were clinical features of a mild sensorimotor neuropathy in five patients (25%) and nerve conduction studies were abnormal in 10 patients (50%). Electrophysiological studies of the whole group showed significant impairment of motor and sensory conduction compared with controls. Sural nerve biopsy and morphometric studies were performed on four patients with clinical neuropathy. There was a reduction in density of myelinated fibres and electron microscopic features of axonal degeneration affecting myelinated and unmyelinated fibres were in evidence. Abnormal mitochondria containing paracrystalline inclusions were seen in the Schwann cell cytoplasm of two nerves.

Authors+Show Affiliations

Department of Medicine, University of Sydney, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2849395

Citation

Yiannikas, C, et al. "Peripheral Neuropathy Associated With Mitochondrial Myopathy." Australian Paediatric Journal, vol. 24 Suppl 1, 1988, pp. 62-3.
Yiannikas C, McLeod JG, Pollard JD, et al. Peripheral neuropathy associated with mitochondrial myopathy. Aust Paediatr J. 1988;24 Suppl 1:62-3.
Yiannikas, C., McLeod, J. G., Pollard, J. D., & Baverstock, J. (1988). Peripheral neuropathy associated with mitochondrial myopathy. Australian Paediatric Journal, 24 Suppl 1, 62-3.
Yiannikas C, et al. Peripheral Neuropathy Associated With Mitochondrial Myopathy. Aust Paediatr J. 1988;24 Suppl 1:62-3. PubMed PMID: 2849395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral neuropathy associated with mitochondrial myopathy. AU - Yiannikas,C, AU - McLeod,J G, AU - Pollard,J D, AU - Baverstock,J, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 62 EP - 3 JF - Australian paediatric journal JO - Aust Paediatr J VL - 24 Suppl 1 N2 - Twenty patients with mitochondrial myopathy were investigated for the presence of peripheral neuropathy. There were clinical features of a mild sensorimotor neuropathy in five patients (25%) and nerve conduction studies were abnormal in 10 patients (50%). Electrophysiological studies of the whole group showed significant impairment of motor and sensory conduction compared with controls. Sural nerve biopsy and morphometric studies were performed on four patients with clinical neuropathy. There was a reduction in density of myelinated fibres and electron microscopic features of axonal degeneration affecting myelinated and unmyelinated fibres were in evidence. Abnormal mitochondria containing paracrystalline inclusions were seen in the Schwann cell cytoplasm of two nerves. SN - 0004-993X UR - https://www.unboundmedicine.com/medline/citation/2849395/Peripheral_neuropathy_associated_with_mitochondrial_myopathy_ L2 - http://www.diseaseinfosearch.org/result/8902 DB - PRIME DP - Unbound Medicine ER -