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Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis.
J Intern Med. 2017 10; 282(4):332-339.JI

Abstract

BACKGROUND

Alcohol consumption and cigarette smoking are modifiable lifestyle factors with important impact on public health. It is unclear whether these factors influence the risk of aortic valve stenosis (AVS).

OBJECTIVE

To investigate the associations of alcohol consumption and smoking, including smoking intensity and time since cessation, with AVS incidence in two prospective cohorts.

METHODS

This analysis was based on data from the Swedish Mammography Cohort and the Cohort of Swedish Men, comprising 69 365 adults without cardiovascular disease at baseline. Participants were followed for AVS incidence and death by linkage to the Swedish National Patient and Causes of Death Registers. Hazard ratios (HR) with 95% confidence intervals (CI) were estimated by Cox proportional hazards regression.

RESULTS

Over a mean follow-up of 15.3 years, 1249 cases of AVS (494 in women and 755 in men) were recorded. Compared with never drinkers of alcohol (lifelong abstainers), the risk of AVS was significantly lower in current light drinkers (1-6 drinks per week [1 drink = 12 g alcohol]; multivariable HR 0.82; 95% CI: 0.68-0.99). The risk of AVS increased with increasing smoking intensity. Compared with never smokers, the HR was 1.46 (95% CI: 1.16-1.85) in current smokers of ≥30 pack-years. Former smokers who had quit smoking 10 or more years previously had similar risk for AVS as never smokers.

CONCLUSIONS

This study suggests that current light alcohol consumption is associated with a lower risk of AVS, and indicates that the association between smoking and AVS risk is reversible.

Authors+Show Affiliations

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Department of Medicine, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28494128

Citation

Larsson, S C., et al. "Alcohol Consumption, Cigarette Smoking and Incidence of Aortic Valve Stenosis." Journal of Internal Medicine, vol. 282, no. 4, 2017, pp. 332-339.
Larsson SC, Wolk A, Bäck M. Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis. J Intern Med. 2017;282(4):332-339.
Larsson, S. C., Wolk, A., & Bäck, M. (2017). Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis. Journal of Internal Medicine, 282(4), 332-339. https://doi.org/10.1111/joim.12630
Larsson SC, Wolk A, Bäck M. Alcohol Consumption, Cigarette Smoking and Incidence of Aortic Valve Stenosis. J Intern Med. 2017;282(4):332-339. PubMed PMID: 28494128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis. AU - Larsson,S C, AU - Wolk,A, AU - Bäck,M, Y1 - 2017/06/01/ PY - 2017/5/12/pubmed PY - 2017/9/25/medline PY - 2017/5/12/entrez KW - alcohol consumption KW - aortic valve stenosis KW - cigarette smoking KW - prospective studies KW - risk factors SP - 332 EP - 339 JF - Journal of internal medicine JO - J Intern Med VL - 282 IS - 4 N2 - BACKGROUND: Alcohol consumption and cigarette smoking are modifiable lifestyle factors with important impact on public health. It is unclear whether these factors influence the risk of aortic valve stenosis (AVS). OBJECTIVE: To investigate the associations of alcohol consumption and smoking, including smoking intensity and time since cessation, with AVS incidence in two prospective cohorts. METHODS: This analysis was based on data from the Swedish Mammography Cohort and the Cohort of Swedish Men, comprising 69 365 adults without cardiovascular disease at baseline. Participants were followed for AVS incidence and death by linkage to the Swedish National Patient and Causes of Death Registers. Hazard ratios (HR) with 95% confidence intervals (CI) were estimated by Cox proportional hazards regression. RESULTS: Over a mean follow-up of 15.3 years, 1249 cases of AVS (494 in women and 755 in men) were recorded. Compared with never drinkers of alcohol (lifelong abstainers), the risk of AVS was significantly lower in current light drinkers (1-6 drinks per week [1 drink = 12 g alcohol]; multivariable HR 0.82; 95% CI: 0.68-0.99). The risk of AVS increased with increasing smoking intensity. Compared with never smokers, the HR was 1.46 (95% CI: 1.16-1.85) in current smokers of ≥30 pack-years. Former smokers who had quit smoking 10 or more years previously had similar risk for AVS as never smokers. CONCLUSIONS: This study suggests that current light alcohol consumption is associated with a lower risk of AVS, and indicates that the association between smoking and AVS risk is reversible. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/28494128/Alcohol_consumption_cigarette_smoking_and_incidence_of_aortic_valve_stenosis_ L2 - https://doi.org/10.1111/joim.12630 DB - PRIME DP - Unbound Medicine ER -