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Operative transvaginal hydrolaparoscopy improve ovulation rate after clomiphene failure in polycystic ovary syndrome.
Gynecol Endocrinol. 2018 Jan; 34(1):32-35.GE

Abstract

Aim of our study was to assess the ovulation rate, with mid-luteal progesterone level and ultrasound follicles monitoring, in PCOS CC-resistant patients undergone transvaginal hydrolaparoscopy ovarian drilling. A prospective observational study was carried out in 123 PCOS, infertile, CC-resistant patients who undergone THL ovarian drilling. Each woman was evaluated by hormonal measurement, and ultrasound evaluation during 6 months follow-up. Progesterone serum levels were assessed on days 20-24 of the cycle after surgical treatment. Pg levels >3 ng/mL were considered as ovulation. Ovulation frequency and the highest mean follicular diameters during the monitoring were recorded. 117 patients complete the study, since six patients were lost to follow-up. Mean follicular diameter during ovulation monitoring was 16.37 mm. Ovulation rate at the follow up was 64.1% one month after treatment, 79.5% after three months and 82.9% after six months. 28 patients conceived during follow-up period. Pregnancy rate was 70.1%. Our study has shown that THL ovarian drilling improves ovulation and pregnancy rate in women with CC-resistant PCOS. We believe that this approach should be offered as second-line therapy at all PCOS CC-resistant women who fail the medical methods of ovulation induction.

Authors+Show Affiliations

a Department of Public Health , University of Naples Federico II , Naples , Italy and.b Department of Neuroscience , Reproductive Sciences and Dentistry, University of Naples Federico II , Naples , Italy.b Department of Neuroscience , Reproductive Sciences and Dentistry, University of Naples Federico II , Naples , Italy.b Department of Neuroscience , Reproductive Sciences and Dentistry, University of Naples Federico II , Naples , Italy.b Department of Neuroscience , Reproductive Sciences and Dentistry, University of Naples Federico II , Naples , Italy.a Department of Public Health , University of Naples Federico II , Naples , Italy and.b Department of Neuroscience , Reproductive Sciences and Dentistry, University of Naples Federico II , Naples , Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28494682

Citation

Giampaolino, Pierluigi, et al. "Operative Transvaginal Hydrolaparoscopy Improve Ovulation Rate After Clomiphene Failure in Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 34, no. 1, 2018, pp. 32-35.
Giampaolino P, De Rosa N, Della Corte L, et al. Operative transvaginal hydrolaparoscopy improve ovulation rate after clomiphene failure in polycystic ovary syndrome. Gynecol Endocrinol. 2018;34(1):32-35.
Giampaolino, P., De Rosa, N., Della Corte, L., Morra, I., Mercorio, A., Nappi, C., & Bifulco, G. (2018). Operative transvaginal hydrolaparoscopy improve ovulation rate after clomiphene failure in polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 34(1), 32-35. https://doi.org/10.1080/09513590.2017.1323204
Giampaolino P, et al. Operative Transvaginal Hydrolaparoscopy Improve Ovulation Rate After Clomiphene Failure in Polycystic Ovary Syndrome. Gynecol Endocrinol. 2018;34(1):32-35. PubMed PMID: 28494682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Operative transvaginal hydrolaparoscopy improve ovulation rate after clomiphene failure in polycystic ovary syndrome. AU - Giampaolino,Pierluigi, AU - De Rosa,Nicoletta, AU - Della Corte,Luigi, AU - Morra,Ilaria, AU - Mercorio,Antonio, AU - Nappi,Carmine, AU - Bifulco,Giuseppe, Y1 - 2017/05/11/ PY - 2017/5/13/pubmed PY - 2018/7/28/medline PY - 2017/5/13/entrez KW - Ovulation rate KW - polycystic ovary syndrome KW - progesterone levels KW - transvaginal hydrolaparoscopy ovarian drilling KW - ultrasound monitoring SP - 32 EP - 35 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 34 IS - 1 N2 - Aim of our study was to assess the ovulation rate, with mid-luteal progesterone level and ultrasound follicles monitoring, in PCOS CC-resistant patients undergone transvaginal hydrolaparoscopy ovarian drilling. A prospective observational study was carried out in 123 PCOS, infertile, CC-resistant patients who undergone THL ovarian drilling. Each woman was evaluated by hormonal measurement, and ultrasound evaluation during 6 months follow-up. Progesterone serum levels were assessed on days 20-24 of the cycle after surgical treatment. Pg levels >3 ng/mL were considered as ovulation. Ovulation frequency and the highest mean follicular diameters during the monitoring were recorded. 117 patients complete the study, since six patients were lost to follow-up. Mean follicular diameter during ovulation monitoring was 16.37 mm. Ovulation rate at the follow up was 64.1% one month after treatment, 79.5% after three months and 82.9% after six months. 28 patients conceived during follow-up period. Pregnancy rate was 70.1%. Our study has shown that THL ovarian drilling improves ovulation and pregnancy rate in women with CC-resistant PCOS. We believe that this approach should be offered as second-line therapy at all PCOS CC-resistant women who fail the medical methods of ovulation induction. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/28494682/Operative_transvaginal_hydrolaparoscopy_improve_ovulation_rate_after_clomiphene_failure_in_polycystic_ovary_syndrome L2 - http://www.tandfonline.com/doi/full/10.1080/09513590.2017.1323204 DB - PRIME DP - Unbound Medicine ER -