Tags

Type your tag names separated by a space and hit enter

Non-contrast-enhanced T1 -weighted MRI of myocardial radiofrequency ablation lesions.
Magn Reson Med. 2018 02; 79(2):879-889.MR

Abstract

PURPOSE

To demonstrate imaging of radiofrequency ablation lesions with non-contrast-enhanced T1 -weighted (T1w) MRI.

METHODS

Fifteen swine underwent left ventricular ablation followed by MRI using different preparations: endocardial or epicardial ablation of naïve animal, or endocardial ablation of animal with myocardial infarction. Lesion imaging was performed using free-breathing, non-contrast-enhanced, T1w sequence with long inversion time (TI). Also acquired were T1 maps and delayed contrast-enhanced (DCE) imaging. Hearts were excised for ex vivo imaging, and sliced for gross pathology and histology.

RESULTS

All ablations were visibly enhanced in non-contrast-enhanced T1w imaging using TI = 700 ms. T1w enhancement agreed with regions of necrosis in gross pathology and histology. Enhanced lesion cores were surrounded by dark bands containing contraction band necrosis, hematoma, and edema. In animals with myocardial infarction, chronic scar was hypointense in T1w, whereas acute ablations were enhanced, allowing discrimination between chronic scar and acute lesions, unlike DCE. Contrast was sufficient to create 3D volume renderings of lesions after minor postprocessing.

CONCLUSIONS

Non-contrast-enhanced T1w imaging with long TI promises to be an effective method for visualizing necrosis within radiofrequency ablation lesions. Enhancement is more specific and stationary than that from DCE. The imaging can be repeated as needed, unlike DCE, and may be especially useful for assessing ablations during or after a procedure. Magn Reson Med 79:879-889, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Links

PMC Free PDF

Authors+Show Affiliations

Guttman MA
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tao S
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Fink S
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kolandaivelu A
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Halperin HR
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Herzka DA
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

MeSH

AnimalsComputer SimulationHeart VentriclesMagnetic Resonance ImagingPericardiumPostoperative ComplicationsRadiofrequency AblationSwine

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28497622

Citation

Guttman, Michael A., et al. "Non-contrast-enhanced T1 -weighted MRI of Myocardial Radiofrequency Ablation Lesions." Magnetic Resonance in Medicine, vol. 79, no. 2, 2018, pp. 879-889.
Guttman MA, Tao S, Fink S, et al. Non-contrast-enhanced T1 -weighted MRI of myocardial radiofrequency ablation lesions. Magn Reson Med. 2018;79(2):879-889.
Guttman, M. A., Tao, S., Fink, S., Kolandaivelu, A., Halperin, H. R., & Herzka, D. A. (2018). Non-contrast-enhanced T1 -weighted MRI of myocardial radiofrequency ablation lesions. Magnetic Resonance in Medicine, 79(2), 879-889. https://doi.org/10.1002/mrm.26750
Guttman MA, et al. Non-contrast-enhanced T1 -weighted MRI of Myocardial Radiofrequency Ablation Lesions. Magn Reson Med. 2018;79(2):879-889. PubMed PMID: 28497622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-contrast-enhanced T1 -weighted MRI of myocardial radiofrequency ablation lesions. AU - Guttman,Michael A, AU - Tao,Susumu, AU - Fink,Sarah, AU - Kolandaivelu,Aravindan, AU - Halperin,Henry R, AU - Herzka,Daniel A, Y1 - 2017/05/11/ PY - 2017/01/03/received PY - 2017/03/27/revised PY - 2017/04/15/accepted PY - 2017/5/13/pubmed PY - 2019/2/12/medline PY - 2017/5/13/entrez KW - RF ablation KW - T1-weighted imaging KW - cardiac MRI KW - lesion assessment KW - non-contrast-enhanced imaging SP - 879 EP - 889 JF - Magnetic resonance in medicine JO - Magn Reson Med VL - 79 IS - 2 N2 - PURPOSE: To demonstrate imaging of radiofrequency ablation lesions with non-contrast-enhanced T1 -weighted (T1w) MRI. METHODS: Fifteen swine underwent left ventricular ablation followed by MRI using different preparations: endocardial or epicardial ablation of naïve animal, or endocardial ablation of animal with myocardial infarction. Lesion imaging was performed using free-breathing, non-contrast-enhanced, T1w sequence with long inversion time (TI). Also acquired were T1 maps and delayed contrast-enhanced (DCE) imaging. Hearts were excised for ex vivo imaging, and sliced for gross pathology and histology. RESULTS: All ablations were visibly enhanced in non-contrast-enhanced T1w imaging using TI = 700 ms. T1w enhancement agreed with regions of necrosis in gross pathology and histology. Enhanced lesion cores were surrounded by dark bands containing contraction band necrosis, hematoma, and edema. In animals with myocardial infarction, chronic scar was hypointense in T1w, whereas acute ablations were enhanced, allowing discrimination between chronic scar and acute lesions, unlike DCE. Contrast was sufficient to create 3D volume renderings of lesions after minor postprocessing. CONCLUSIONS: Non-contrast-enhanced T1w imaging with long TI promises to be an effective method for visualizing necrosis within radiofrequency ablation lesions. Enhancement is more specific and stationary than that from DCE. The imaging can be repeated as needed, unlike DCE, and may be especially useful for assessing ablations during or after a procedure. Magn Reson Med 79:879-889, 2018. © 2017 International Society for Magnetic Resonance in Medicine. SN - 1522-2594 UR - https://www.unboundmedicine.com/medline/citation/28497622/Non_contrast_enhanced_T1__weighted_MRI_of_myocardial_radiofrequency_ablation_lesions_ DB - PRIME DP - Unbound Medicine ER -