Tags

Type your tag names separated by a space and hit enter

Fate and O-methylating detoxification of Tetrabromobisphenol A (TBBPA) in two earthworms (Metaphire guillelmi and Eisenia fetida).
Environ Pollut. 2017 Aug; 227:526-533.EP

Abstract

Tetrabromobisphenol A (TBBPA) is the world's most widely used brominated flame retardant but there is growing concern about its fate and toxicity in terrestrial organisms. In this study, two ecologically different earthworms, Metaphire guillelmi and Eisenia fetida, were exposed to soil spiked with 14C-labeled TBBPA for 21 days. M. guillelmi accumulated more TBBPA than E. fetida, evidenced by a 2.7-fold higher 14C-uptake rate and a 1.3-fold higher biota-soil accumulation factor. Considerable amounts of bound residues (up to 40% for M. guillelmi and 18% for E. fetida) formed rapidly in the bodies of both earthworms. 14C accumulated mostly in the gut of M. guillemi and in the skin of E. fetida, suggesting that its uptake by M. guillelmi was mainly via gut processes whereas in E. fetida epidermal adsorption predominated. The TBBPA transformation potential was greater in M. guillelmi than in E. fetida, since only 5% vs. 34% of extractable 14C remained as the parent compound after 21 days of exposure. Besides polar metabolites, the major metabolites in both earthworms were TBBPA mono- and dimethyl ethers (O-methylation products of TBBPA). Acute toxicity assessments using filter paper and natural soil tests showed that the methylation metabolites were much less toxic than the parent TBBPA to both earthworms. It indicated that earthworms used O-methylation to detoxify TBBPA, and M. guillelmi exhibited the higher detoxification ability than E. fetida. These results imply that if only the free parent compound TBBPA is measured, not only bioaccumulation may be underestimated but also its difference between earthworm species may be misestimated. The species-dependent fate of TBBPA may provide a better indicator of the differing sensitivities of earthworms to this environmental contaminant.

Authors+Show Affiliations

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China; School of Chemistry and Environmental Engineering, Jiangsu University of Technology, 1801 Zhongwu Avenue, Changzhou 213001, China.State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China.State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China.State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China.State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China.State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. Electronic address: ekxr@nju.edu.cn.State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. Electronic address: ji@nju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28499262

Citation

Chen, Xian, et al. "Fate and O-methylating Detoxification of Tetrabromobisphenol a (TBBPA) in Two Earthworms (Metaphire Guillelmi and Eisenia Fetida)." Environmental Pollution (Barking, Essex : 1987), vol. 227, 2017, pp. 526-533.
Chen X, Gu J, Wang Y, et al. Fate and O-methylating detoxification of Tetrabromobisphenol A (TBBPA) in two earthworms (Metaphire guillelmi and Eisenia fetida). Environ Pollut. 2017;227:526-533.
Chen, X., Gu, J., Wang, Y., Gu, X., Zhao, X., Wang, X., & Ji, R. (2017). Fate and O-methylating detoxification of Tetrabromobisphenol A (TBBPA) in two earthworms (Metaphire guillelmi and Eisenia fetida). Environmental Pollution (Barking, Essex : 1987), 227, 526-533. https://doi.org/10.1016/j.envpol.2017.04.090
Chen X, et al. Fate and O-methylating Detoxification of Tetrabromobisphenol a (TBBPA) in Two Earthworms (Metaphire Guillelmi and Eisenia Fetida). Environ Pollut. 2017;227:526-533. PubMed PMID: 28499262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fate and O-methylating detoxification of Tetrabromobisphenol A (TBBPA) in two earthworms (Metaphire guillelmi and Eisenia fetida). AU - Chen,Xian, AU - Gu,Jianqiang, AU - Wang,Yongfeng, AU - Gu,Xueyuan, AU - Zhao,Xiaopeng, AU - Wang,Xiaorong, AU - Ji,Rong, Y1 - 2017/05/09/ PY - 2017/03/10/received PY - 2017/04/26/revised PY - 2017/04/29/accepted PY - 2017/5/13/pubmed PY - 2017/6/29/medline PY - 2017/5/13/entrez KW - Bioaccumulation KW - Earthworms KW - Metabolism KW - Tetrabromobisphenol A KW - Toxicity SP - 526 EP - 533 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 227 N2 - Tetrabromobisphenol A (TBBPA) is the world's most widely used brominated flame retardant but there is growing concern about its fate and toxicity in terrestrial organisms. In this study, two ecologically different earthworms, Metaphire guillelmi and Eisenia fetida, were exposed to soil spiked with 14C-labeled TBBPA for 21 days. M. guillelmi accumulated more TBBPA than E. fetida, evidenced by a 2.7-fold higher 14C-uptake rate and a 1.3-fold higher biota-soil accumulation factor. Considerable amounts of bound residues (up to 40% for M. guillelmi and 18% for E. fetida) formed rapidly in the bodies of both earthworms. 14C accumulated mostly in the gut of M. guillemi and in the skin of E. fetida, suggesting that its uptake by M. guillelmi was mainly via gut processes whereas in E. fetida epidermal adsorption predominated. The TBBPA transformation potential was greater in M. guillelmi than in E. fetida, since only 5% vs. 34% of extractable 14C remained as the parent compound after 21 days of exposure. Besides polar metabolites, the major metabolites in both earthworms were TBBPA mono- and dimethyl ethers (O-methylation products of TBBPA). Acute toxicity assessments using filter paper and natural soil tests showed that the methylation metabolites were much less toxic than the parent TBBPA to both earthworms. It indicated that earthworms used O-methylation to detoxify TBBPA, and M. guillelmi exhibited the higher detoxification ability than E. fetida. These results imply that if only the free parent compound TBBPA is measured, not only bioaccumulation may be underestimated but also its difference between earthworm species may be misestimated. The species-dependent fate of TBBPA may provide a better indicator of the differing sensitivities of earthworms to this environmental contaminant. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/28499262/Fate_and_O_methylating_detoxification_of_Tetrabromobisphenol_A__TBBPA__in_two_earthworms__Metaphire_guillelmi_and_Eisenia_fetida__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(17)30990-9 DB - PRIME DP - Unbound Medicine ER -