ZnO).
Int J Biol Macromol. 2017 Oct; 103:234-241.IJ

Abstract

Treatment against bacterial infection is crucial for wound healing. Development of cost-effective antibacterial agent with wound healing properties is still in high demand. In this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (CS/PVA/ZnO) beads as novel antibacterial agent with wound healing properties. CS/PVA/ZnO beads were synthesized, and characterized by using XRD, FTIR, SEM, and TEM analysis. Pure chitosan exhibits two peaks at 2θ=10 and 20 and the CS/PVA polymer matrix exhibit the peaks at 2θ=19.7° and another of low intensity at 2θ=11.5°. Pure ZnO shows the characteristic peaks at (100), (002), (101), (102), (110), (103), (200), and (112) that were in good agreement with wurtzite ore having hexagonal lattice structure. The antibacterial activity of CS/PVA/ZnO against Escherichia coli, and Staphylococcus aureus were evaluated with the zone of inhibition method. Antibacterial activity of CS/PVA/ZnO was higher than that of chitosan (CS) and poly(vinyl alcohol (PVA). Hemocompatibility and biocompatibility of CS/PVA/ZnO were tested in in vitro. Wound healing properties of CS/PVA/ZnO were tested in mice skin wound. CS/PVA/ZnO showed strong antimicrobial, wound healing effect, hemocompatibility and biocompatibility. Hence the results strongly support the possibility of using this novel CS/PVA/ZnO material for the anti bacterial and wound healing application.

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Authors+Show Affiliations

Gutha Y

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. Electronic address: guthayuvaraja@tju.edu.cn.

Pathak JL

School of pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin 300072, China.

Zhang W

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Zhang Y

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Jiao X

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. Electronic address: 158047@tju.edu.cn.

MeSH

Anti-Bacterial AgentsCell Line, TumorChitosanEscherichia coliHumansMicrospheresPolyvinyl AlcoholStaphylococcus aureusWound HealingZinc Oxide

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28499948

Citation

Gutha, Yuvaraja, et al. "Antibacterial and Wound Healing Properties of Chitosan/poly(vinyl Alcohol)/zinc Oxide Beads (CS/PVA/ZnO)." International Journal of Biological Macromolecules, vol. 103, 2017, pp. 234-241.

Gutha Y, Pathak JL, Zhang W, et al. Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO). Int J Biol Macromol. 2017;103:234-241.

Gutha, Y., Pathak, J. L., Zhang, W., Zhang, Y., & Jiao, X. (2017). Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO). International Journal of Biological Macromolecules, 103, 234-241. https://doi.org/10.1016/j.ijbiomac.2017.05.020

Gutha Y, et al. Antibacterial and Wound Healing Properties of Chitosan/poly(vinyl Alcohol)/zinc Oxide Beads (CS/PVA/ZnO). Int J Biol Macromol. 2017;103:234-241. PubMed PMID: 28499948.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO). AU - Gutha,Yuvaraja, AU - Pathak,Janak L, AU - Zhang,Weijiang, AU - Zhang,Yaping, AU - Jiao,Xu, Y1 - 2017/05/10/ PY - 2017/03/13/received PY - 2017/04/17/revised PY - 2017/05/05/accepted PY - 2017/5/14/pubmed PY - 2018/3/31/medline PY - 2017/5/14/entrez KW - Antibacterial agent KW - Biocompatibility KW - CS/PVA/ZnO KW - Wound healing SP - 234 EP - 241 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 103 N2 - Treatment against bacterial infection is crucial for wound healing. Development of cost-effective antibacterial agent with wound healing properties is still in high demand. In this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (CS/PVA/ZnO) beads as novel antibacterial agent with wound healing properties. CS/PVA/ZnO beads were synthesized, and characterized by using XRD, FTIR, SEM, and TEM analysis. Pure chitosan exhibits two peaks at 2θ=10 and 20 and the CS/PVA polymer matrix exhibit the peaks at 2θ=19.7° and another of low intensity at 2θ=11.5°. Pure ZnO shows the characteristic peaks at (100), (002), (101), (102), (110), (103), (200), and (112) that were in good agreement with wurtzite ore having hexagonal lattice structure. The antibacterial activity of CS/PVA/ZnO against Escherichia coli, and Staphylococcus aureus were evaluated with the zone of inhibition method. Antibacterial activity of CS/PVA/ZnO was higher than that of chitosan (CS) and poly(vinyl alcohol (PVA). Hemocompatibility and biocompatibility of CS/PVA/ZnO were tested in in vitro. Wound healing properties of CS/PVA/ZnO were tested in mice skin wound. CS/PVA/ZnO showed strong antimicrobial, wound healing effect, hemocompatibility and biocompatibility. Hence the results strongly support the possibility of using this novel CS/PVA/ZnO material for the anti bacterial and wound healing application. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/28499948/Antibacterial_and_wound_healing_properties_of_chitosan/poly_vinyl_alcohol_/zinc_oxide_beads__CS/PVA/ZnO__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(17)30933-9 DB - PRIME DP - Unbound Medicine ER -

Tags

Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO).Int J Biol Macromol. 2017 Oct; 103:234-241.IJ