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Association between metabolic syndrome and chronic kidney disease in a Chinese urban population.

Abstract

BACKGROUND

Few studies have examined the relationships between the prevalence of chronic kidney disease (CKD) and the metabolic risk factors in a developing country such as China, where genetic and environmental backgrounds differ from those in Western countries.

METHODS

The subjects of this cross-sectional study were the individuals from 18 to 92y. The metabolic syndrome (MetS) was defined based on the criteria of Adult Treatment Panel Third Report (ATP III), but using body mass index (BMI) instead of waist circumference. CKD was defined as decreased estimated glomerular filtration rate (eGFR<60mL/min/1.73m2) or presence of proteinuria (urine protein≥1+) assessed using dipstick method.

RESULTS

A total of 26,601 subjects (average age of 48.7y) were analyzed. Among them, the prevalence of the MetS and CKD was 36.4% and 3.0%, respectively. After adjustment for age, gender, cigarette smoking and alcohol drinking, the prevalence of CKD was significantly greater in subjects with than without MetS (OR 1.99, 95% CI 1.57-2.53, p<0.001). Multivariate-adjusted odd ratios for CKD in subjects with 3, 4 or 5 MetS components were 1.82 (95% CI 1.31-2.52, p<0.001), 2.92 (95% CI 2.09-4.09, p<0.001), and 3.07 (95% CI 1.67-5.67, p<0.001), respectively. After further adjustments were made for the other components of MetS, only high fasting glucose (OR 1.52, 95% CI 1.12-2.05) were significant risk factors for reduced renal function(eGFR<60mL/min/1.73m2). High blood pressure (OR 1.81, 95% CI 1,42-2.29), high triglycerides (OR 1.34, 95% CI 1.11-1.67) and high fasting glucose (OR 2.07, 95% CI 1.62-2.66) were significant risk factors for proteinuria.

CONCLUSIONS

MetS was highly prevalent in the middle-aged and elderly Chinese population in the city of Jinan. There was a graded relationship between the number of MetS components and risk of CKD. High fasting blood glucose levels were the main risk factor of reduced renal function. High blood pressure, high fasting blood glucose levels and high triglycerides were main risk factors for proteinuria.

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  • Authors+Show Affiliations

    ,

    Department of Nephrology, Shandong Qianfoshan Hospital affiliated to Shandong University, No. 16766, Jingshi Road, Jinan 250014,China.

    ,

    Department of Nephrology, Shandong Qianfoshan Hospital affiliated to Shandong University, No. 16766, Jingshi Road, Jinan 250014,China.

    ,

    Department of Nephrology, Shandong Qianfoshan Hospital affiliated to Shandong University, No. 16766, Jingshi Road, Jinan 250014,China.

    ,

    Department of Nephrology, Shandong Qianfoshan Hospital affiliated to Shandong University, No. 16766, Jingshi Road, Jinan 250014,China.

    ,

    Department of Nephrology, Shandong Qianfoshan Hospital affiliated to Shandong University, No. 16766, Jingshi Road, Jinan 250014,China.

    ,

    Department of Nephrology, Shandong Qianfoshan Hospital affiliated to Shandong University, No. 16766, Jingshi Road, Jinan 250014,China.

    Department of Nephrology, Shandong Qianfoshan Hospital affiliated to Shandong University, No. 16766, Jingshi Road, Jinan 250014,China. Electronic address: qianyixudongmei@163.com.

    Source

    MeSH

    China
    Cross-Sectional Studies
    Environment
    Female
    Glomerular Filtration Rate
    Humans
    Male
    Metabolic Syndrome
    Middle Aged
    Proteinuria
    Renal Insufficiency, Chronic
    Urban Population

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28501388

    Citation

    Chen, Juan, et al. "Association Between Metabolic Syndrome and Chronic Kidney Disease in a Chinese Urban Population." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 470, 2017, pp. 103-108.
    Chen J, Kong X, Jia X, et al. Association between metabolic syndrome and chronic kidney disease in a Chinese urban population. Clin Chim Acta. 2017;470:103-108.
    Chen, J., Kong, X., Jia, X., Li, W., Wang, Z., Cui, M., & Xu, D. (2017). Association between metabolic syndrome and chronic kidney disease in a Chinese urban population. Clinica Chimica Acta; International Journal of Clinical Chemistry, 470, pp. 103-108. doi:10.1016/j.cca.2017.05.012.
    Chen J, et al. Association Between Metabolic Syndrome and Chronic Kidney Disease in a Chinese Urban Population. Clin Chim Acta. 2017;470:103-108. PubMed PMID: 28501388.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between metabolic syndrome and chronic kidney disease in a Chinese urban population. AU - Chen,Juan, AU - Kong,Xianglei, AU - Jia,Xiaoyan, AU - Li,Wenbin, AU - Wang,Zunsong, AU - Cui,Meiyu, AU - Xu,Dongmei, Y1 - 2017/05/10/ PY - 2017/02/03/received PY - 2017/05/07/revised PY - 2017/05/09/accepted PY - 2017/5/16/pubmed PY - 2018/1/9/medline PY - 2017/5/15/entrez KW - China KW - Chronic kidney disease (CKD) KW - Metabolic syndrome KW - Proteinuria SP - 103 EP - 108 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 470 N2 - BACKGROUND: Few studies have examined the relationships between the prevalence of chronic kidney disease (CKD) and the metabolic risk factors in a developing country such as China, where genetic and environmental backgrounds differ from those in Western countries. METHODS: The subjects of this cross-sectional study were the individuals from 18 to 92y. The metabolic syndrome (MetS) was defined based on the criteria of Adult Treatment Panel Third Report (ATP III), but using body mass index (BMI) instead of waist circumference. CKD was defined as decreased estimated glomerular filtration rate (eGFR<60mL/min/1.73m2) or presence of proteinuria (urine protein≥1+) assessed using dipstick method. RESULTS: A total of 26,601 subjects (average age of 48.7y) were analyzed. Among them, the prevalence of the MetS and CKD was 36.4% and 3.0%, respectively. After adjustment for age, gender, cigarette smoking and alcohol drinking, the prevalence of CKD was significantly greater in subjects with than without MetS (OR 1.99, 95% CI 1.57-2.53, p<0.001). Multivariate-adjusted odd ratios for CKD in subjects with 3, 4 or 5 MetS components were 1.82 (95% CI 1.31-2.52, p<0.001), 2.92 (95% CI 2.09-4.09, p<0.001), and 3.07 (95% CI 1.67-5.67, p<0.001), respectively. After further adjustments were made for the other components of MetS, only high fasting glucose (OR 1.52, 95% CI 1.12-2.05) were significant risk factors for reduced renal function(eGFR<60mL/min/1.73m2). High blood pressure (OR 1.81, 95% CI 1,42-2.29), high triglycerides (OR 1.34, 95% CI 1.11-1.67) and high fasting glucose (OR 2.07, 95% CI 1.62-2.66) were significant risk factors for proteinuria. CONCLUSIONS: MetS was highly prevalent in the middle-aged and elderly Chinese population in the city of Jinan. There was a graded relationship between the number of MetS components and risk of CKD. High fasting blood glucose levels were the main risk factor of reduced renal function. High blood pressure, high fasting blood glucose levels and high triglycerides were main risk factors for proteinuria. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/28501388/Association_between_metabolic_syndrome_and_chronic_kidney_disease_in_a_Chinese_urban_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(17)30176-6 DB - PRIME DP - Unbound Medicine ER -