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Local and systemic humoral immune response in farmed Atlantic salmon (Salmo salar L.) under a natural amoebic gill disease outbreak.
Fish Shellfish Immunol 2017; 66:207-216FS

Abstract

Amoebic gill disease (AGD), caused by the protozoan parasite Neoparamoeba perurans, is one of the most significant infectious diseases for Atlantic salmon (Salmo salar L.) mariculture. The present study investigated the humoral immune response (both local in gill mucus and systemic in serum) of farmed Atlantic salmon naturally infected with N. perurans in commercial sea pens, at two different stages of the disease and after freshwater treatment. Parameters analysed included activity of immune related enzymes (i.e. lysozyme, peroxidase, protease, anti-protease, esterase, alkaline phosphatase), IgM levels, and the terminal carbohydrate profile in the gill mucus. Overall, greater variations between groups were noted in the immune parameters determined in gill mucus than the equivalent in the serum. In gill mucus, IgM levels and peroxidase, lysozyme, esterase and protease activities were decreased in fish showing longer exposure time to the infection and higher disease severity, then showed a sequential increase after treatment. Results obtained highlight the capacity of gills to elicit a local response to the infection, indicate an impaired immune response at the later stages of the disease, and show partial reestablishment of the host immune status after freshwater treatment. In addition to providing data on the humoral response to AGD, this study increases knowledge on gill mucosal humoral immunity, since some of the parameters were analysed for the first time in gill mucus.

Authors+Show Affiliations

Marine and Freshwater Research Centre, Galway-Mayo Institute of Technology, Dublin Road, Galway, Co. Galway, Ireland; FishVet Group Ireland, Unit 7b Oranmore Business Park, Oranmore, Co. Galway, Ireland. Electronic address: mar.marcos.lopez@gmail.com.Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, Murcia, Spain.FishVet Group Ireland, Unit 7b Oranmore Business Park, Oranmore, Co. Galway, Ireland.Marine and Freshwater Research Centre, Galway-Mayo Institute of Technology, Dublin Road, Galway, Co. Galway, Ireland.Marine and Freshwater Research Centre, Galway-Mayo Institute of Technology, Dublin Road, Galway, Co. Galway, Ireland.Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, Murcia, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28501445

Citation

Marcos-López, Mar, et al. "Local and Systemic Humoral Immune Response in Farmed Atlantic Salmon (Salmo Salar L.) Under a Natural Amoebic Gill Disease Outbreak." Fish & Shellfish Immunology, vol. 66, 2017, pp. 207-216.
Marcos-López M, Espinosa Ruiz C, Rodger HD, et al. Local and systemic humoral immune response in farmed Atlantic salmon (Salmo salar L.) under a natural amoebic gill disease outbreak. Fish Shellfish Immunol. 2017;66:207-216.
Marcos-López, M., Espinosa Ruiz, C., Rodger, H. D., O'Connor, I., MacCarthy, E., & Esteban, M. Á. (2017). Local and systemic humoral immune response in farmed Atlantic salmon (Salmo salar L.) under a natural amoebic gill disease outbreak. Fish & Shellfish Immunology, 66, pp. 207-216. doi:10.1016/j.fsi.2017.05.029.
Marcos-López M, et al. Local and Systemic Humoral Immune Response in Farmed Atlantic Salmon (Salmo Salar L.) Under a Natural Amoebic Gill Disease Outbreak. Fish Shellfish Immunol. 2017;66:207-216. PubMed PMID: 28501445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local and systemic humoral immune response in farmed Atlantic salmon (Salmo salar L.) under a natural amoebic gill disease outbreak. AU - Marcos-López,Mar, AU - Espinosa Ruiz,Cristóbal, AU - Rodger,Hamish D, AU - O'Connor,Ian, AU - MacCarthy,Eugene, AU - Esteban,M Ángeles, Y1 - 2017/05/10/ PY - 2017/02/13/received PY - 2017/05/05/revised PY - 2017/05/09/accepted PY - 2017/5/16/pubmed PY - 2017/12/16/medline PY - 2017/5/15/entrez KW - Amoebic gill disease KW - Atlantic salmon (Salmo salar L.) KW - Gill mucus KW - Humoral immunity KW - Serum SP - 207 EP - 216 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol. VL - 66 N2 - Amoebic gill disease (AGD), caused by the protozoan parasite Neoparamoeba perurans, is one of the most significant infectious diseases for Atlantic salmon (Salmo salar L.) mariculture. The present study investigated the humoral immune response (both local in gill mucus and systemic in serum) of farmed Atlantic salmon naturally infected with N. perurans in commercial sea pens, at two different stages of the disease and after freshwater treatment. Parameters analysed included activity of immune related enzymes (i.e. lysozyme, peroxidase, protease, anti-protease, esterase, alkaline phosphatase), IgM levels, and the terminal carbohydrate profile in the gill mucus. Overall, greater variations between groups were noted in the immune parameters determined in gill mucus than the equivalent in the serum. In gill mucus, IgM levels and peroxidase, lysozyme, esterase and protease activities were decreased in fish showing longer exposure time to the infection and higher disease severity, then showed a sequential increase after treatment. Results obtained highlight the capacity of gills to elicit a local response to the infection, indicate an impaired immune response at the later stages of the disease, and show partial reestablishment of the host immune status after freshwater treatment. In addition to providing data on the humoral response to AGD, this study increases knowledge on gill mucosal humoral immunity, since some of the parameters were analysed for the first time in gill mucus. SN - 1095-9947 UR - https://www.unboundmedicine.com/medline/citation/28501445/Local_and_systemic_humoral_immune_response_in_farmed_Atlantic_salmon__Salmo_salar_L___under_a_natural_amoebic_gill_disease_outbreak_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(17)30269-3 DB - PRIME DP - Unbound Medicine ER -