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A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus).

Abstract

We compared the effects of hibernation inactivity and 14-day hindlimb unloading in non-hibernating period on biochemical, rheological, and hematological parameters of blood in Daurian ground squirrels (Spermophilus dauricus). Twenty-four squirrels were randomly divided into four groups: control (CON), hibernation (HIB), post-hibernation (POST), and 14-day hindlimb unloading (HU). The results showed that serum enzymes (L-lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase) activities decreased in HIB, POST, and HU squirrels compared with CON. Total protein (including albumin and globulin) maintained in HIB but decreased in HU compared with CON. Total cholesterol and high-density lipoprotein-cholesterol increased in HIB but maintained in HU and POST compared with CON. Meanwhile, serum creatinine decreased and urea increased in HU compared with CON. All blood ions concentrations were unchanged in HIB, POST, and HU squirrels compared with CON except calcium which increased in HIB compared with CON, and phosphorus which increased in HIB and POST compared with CON. Most of detected serum biochemical analytes in POST recovered to the CON level. Blood viscosity, which was unchanged in all shear rates in HU, increased in HIB and recovered in POST in lower shear rates compared with CON. Erythrocyte and corpuscular volume decreased in HIB and HU but maintained in POST compared with CON. All the routine hematological parameters recovered in POST as compared with CON except platelet, which decreased in HIB and POST but maintained in HU compared with CON. In conclusion, our results suggested a remarkable ability to maintain blood homeostasis in hibernating squirrels.

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  • Authors+Show Affiliations

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    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China.

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    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China. Department of Genetics and Molecular Biology, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

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    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China.

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    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China.

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    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China.

    ,

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China.

    ,

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China.

    ,

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China.

    ,

    Gravitational Physiology and Medicine Research Unit, Institute of Physiology, Center of Physiological Medicine, Medical University Graz, Graz, Austria. nandu.goswami@medunigraz.at.

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China. gaoyunf@nwu.edu.cn.

    Source

    MeSH

    Animals
    Blood Physiological Phenomena
    Hibernation
    Hindlimb
    Hindlimb Suspension
    Muscle, Skeletal
    Muscular Atrophy
    Sciuridae

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28501920

    Citation

    Hu, Huan-Xin, et al. "A Dramatic Blood Plasticity in Hibernating and 14-day Hindlimb Unloading Daurian Ground Squirrels (Spermophilus Dauricus)." Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, vol. 187, no. 5-6, 2017, pp. 869-879.
    Hu HX, Du FY, Fu WW, et al. A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus). J Comp Physiol B, Biochem Syst Environ Physiol. 2017;187(5-6):869-879.
    Hu, H. X., Du, F. Y., Fu, W. W., Jiang, S. F., Cao, J., Xu, S. H., ... Gao, Y. F. (2017). A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus). Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, 187(5-6), pp. 869-879. doi:10.1007/s00360-017-1092-7.
    Hu HX, et al. A Dramatic Blood Plasticity in Hibernating and 14-day Hindlimb Unloading Daurian Ground Squirrels (Spermophilus Dauricus). J Comp Physiol B, Biochem Syst Environ Physiol. 2017;187(5-6):869-879. PubMed PMID: 28501920.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus). AU - Hu,Huan-Xin, AU - Du,Fang-Ying, AU - Fu,Wei-Wei, AU - Jiang,Shan-Feng, AU - Cao,Jin, AU - Xu,Shen-Hui, AU - Wang,Hui-Ping, AU - Chang,Hui, AU - Goswami,Nandu, AU - Gao,Yun-Fang, Y1 - 2017/05/13/ PY - 2016/08/31/received PY - 2017/04/06/accepted PY - 2017/03/21/revised PY - 2017/5/16/pubmed PY - 2018/4/4/medline PY - 2017/5/15/entrez KW - Blood biochemical analytes KW - Disuse KW - Hibernation KW - Rheology KW - Routine hematological parameters SP - 869 EP - 879 JF - Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology JO - J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. VL - 187 IS - 5-6 N2 - We compared the effects of hibernation inactivity and 14-day hindlimb unloading in non-hibernating period on biochemical, rheological, and hematological parameters of blood in Daurian ground squirrels (Spermophilus dauricus). Twenty-four squirrels were randomly divided into four groups: control (CON), hibernation (HIB), post-hibernation (POST), and 14-day hindlimb unloading (HU). The results showed that serum enzymes (L-lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase) activities decreased in HIB, POST, and HU squirrels compared with CON. Total protein (including albumin and globulin) maintained in HIB but decreased in HU compared with CON. Total cholesterol and high-density lipoprotein-cholesterol increased in HIB but maintained in HU and POST compared with CON. Meanwhile, serum creatinine decreased and urea increased in HU compared with CON. All blood ions concentrations were unchanged in HIB, POST, and HU squirrels compared with CON except calcium which increased in HIB compared with CON, and phosphorus which increased in HIB and POST compared with CON. Most of detected serum biochemical analytes in POST recovered to the CON level. Blood viscosity, which was unchanged in all shear rates in HU, increased in HIB and recovered in POST in lower shear rates compared with CON. Erythrocyte and corpuscular volume decreased in HIB and HU but maintained in POST compared with CON. All the routine hematological parameters recovered in POST as compared with CON except platelet, which decreased in HIB and POST but maintained in HU compared with CON. In conclusion, our results suggested a remarkable ability to maintain blood homeostasis in hibernating squirrels. SN - 1432-136X UR - https://www.unboundmedicine.com/medline/citation/28501920/A_dramatic_blood_plasticity_in_hibernating_and_14_day_hindlimb_unloading_Daurian_ground_squirrels__Spermophilus_dauricus__ L2 - http://dx.doi.org/10.1007/s00360-017-1092-7 DB - PRIME DP - Unbound Medicine ER -