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Comparison of the effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the cat gastric fundus.
Eur J Pharmacol. 1988 Jul 26; 152(1-2):71-82.EJ

Abstract

The possible involvement of vasoactive intestinal polypeptide (VIP) in the non-adrenergic non-cholinergic (NANC) relaxation of the cat gastric fundus was studied in circular and longitudinal muscle strips. Cumulative transmural stimulation induced a frequency-dependent relaxation, while cumulative administration of VIP induced a concentration-dependent relaxation. Tetrodotoxin almost completely antagonized the relaxation induced by transmural stimulation (1 Hz), but did not influence the relaxation induced by VIP (10(-7) M); the latter was not influenced by hexamethonium or propranolol plus phentolamine. Trypsin (30 min incubation) and VIP antiserum (1 h incubation) prevented the relaxation induced by VIP and reduced that induced by transmural stimulation, but did not influence the relaxation induced by isopropylnoradrenaline. Two putative VIP receptor antagonists, [AcTyr1]hGRF-(1-40)OH and [4Cl-D-Phe6,Leu17]VIP, did not influence the relaxation induced by VIP or transmural stimulation. These results are compatible with the hypothesis that VIP is involved in the NANC relaxation of the cat gastric fundus, although participation of a non-VIP component cannot be excluded.

Authors+Show Affiliations

Heymans Institute of Pharmacology, University of Gent Medical School, Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2850204

Citation

D'Amato, M, et al. "Comparison of the Effect of Vasoactive Intestinal Polypeptide and Non-adrenergic Non-cholinergic Neurone Stimulation in the Cat Gastric Fundus." European Journal of Pharmacology, vol. 152, no. 1-2, 1988, pp. 71-82.
D'Amato M, De Beurme FA, Lefebvre RA. Comparison of the effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the cat gastric fundus. Eur J Pharmacol. 1988;152(1-2):71-82.
D'Amato, M., De Beurme, F. A., & Lefebvre, R. A. (1988). Comparison of the effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the cat gastric fundus. European Journal of Pharmacology, 152(1-2), 71-82.
D'Amato M, De Beurme FA, Lefebvre RA. Comparison of the Effect of Vasoactive Intestinal Polypeptide and Non-adrenergic Non-cholinergic Neurone Stimulation in the Cat Gastric Fundus. Eur J Pharmacol. 1988 Jul 26;152(1-2):71-82. PubMed PMID: 2850204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the cat gastric fundus. AU - D'Amato,M, AU - De Beurme,F A, AU - Lefebvre,R A, PY - 1988/7/26/pubmed PY - 1988/7/26/medline PY - 1988/7/26/entrez SP - 71 EP - 82 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 152 IS - 1-2 N2 - The possible involvement of vasoactive intestinal polypeptide (VIP) in the non-adrenergic non-cholinergic (NANC) relaxation of the cat gastric fundus was studied in circular and longitudinal muscle strips. Cumulative transmural stimulation induced a frequency-dependent relaxation, while cumulative administration of VIP induced a concentration-dependent relaxation. Tetrodotoxin almost completely antagonized the relaxation induced by transmural stimulation (1 Hz), but did not influence the relaxation induced by VIP (10(-7) M); the latter was not influenced by hexamethonium or propranolol plus phentolamine. Trypsin (30 min incubation) and VIP antiserum (1 h incubation) prevented the relaxation induced by VIP and reduced that induced by transmural stimulation, but did not influence the relaxation induced by isopropylnoradrenaline. Two putative VIP receptor antagonists, [AcTyr1]hGRF-(1-40)OH and [4Cl-D-Phe6,Leu17]VIP, did not influence the relaxation induced by VIP or transmural stimulation. These results are compatible with the hypothesis that VIP is involved in the NANC relaxation of the cat gastric fundus, although participation of a non-VIP component cannot be excluded. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/2850204/Comparison_of_the_effect_of_vasoactive_intestinal_polypeptide_and_non_adrenergic_non_cholinergic_neurone_stimulation_in_the_cat_gastric_fundus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(88)90837-0 DB - PRIME DP - Unbound Medicine ER -