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Neural response to catecholamine depletion in remitted bulimia nervosa: Relation to depression and relapse.
Eur Neuropsychopharmacol. 2017 07; 27(7):633-646.EN

Abstract

Bulimia nervosa has been associated with a dysregulated catecholamine system. Nevertheless, the influence of this dysregulation on bulimic symptoms, on neural activity, and on the course of the illness is not clear yet. An instructive paradigm for directly investigating the relationship between catecholaminergic functioning and bulimia nervosa has involved the behavioral and neural responses to experimental catecholamine depletion. The purpose of this study was to examine the neural substrate of catecholaminergic dysfunction in bulimia nervosa and its relationship to relapse. In a randomized, double-blind and crossover study design, catecholamine depletion was achieved by using the oral administration of alpha-methyl-paratyrosine (AMPT) over 24 h in 18 remitted bulimic (rBN) and 22 healthy (HC) female participants. Cerebral blood flow (CBF) was measured using a pseudo continuous arterial spin labeling (pCASL) sequence. In a follow-up telephone interview, bulimic relapse was assessed. Following AMPT, rBN participants revealed an increased vigor reduction and CBF decreases in the pallidum and posterior midcingulate cortex (pMCC) relative to HC participants showing no CBF changes in these regions. These results indicated that the pallidum and the pMCC are the functional neural correlates of the dysregulated catecholamine system in bulimia nervosa. Bulimic relapse was associated with increased depressive symptoms and CBF reduction in the hippocampus/parahippocampal gyrus following catecholamine depletion. AMPT-induced increased CBF in this region predicted staying in remission. These findings demonstrated the importance of depressive symptoms and the stress system in the course of bulimia nervosa.

Authors+Show Affiliations

Division of Molecular Psychiatry, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.Division of Molecular Psychiatry, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.Psychiatric Neuroimaging Unit, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland.Division of Molecular Psychiatry, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland. Electronic address: gregor.hasler@puk.unibe.ch.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28502528

Citation

Mueller, Stefanie Verena, et al. "Neural Response to Catecholamine Depletion in Remitted Bulimia Nervosa: Relation to Depression and Relapse." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 27, no. 7, 2017, pp. 633-646.
Mueller SV, Mihov Y, Federspiel A, et al. Neural response to catecholamine depletion in remitted bulimia nervosa: Relation to depression and relapse. Eur Neuropsychopharmacol. 2017;27(7):633-646.
Mueller, S. V., Mihov, Y., Federspiel, A., Wiest, R., & Hasler, G. (2017). Neural response to catecholamine depletion in remitted bulimia nervosa: Relation to depression and relapse. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 27(7), 633-646. https://doi.org/10.1016/j.euroneuro.2017.04.002
Mueller SV, et al. Neural Response to Catecholamine Depletion in Remitted Bulimia Nervosa: Relation to Depression and Relapse. Eur Neuropsychopharmacol. 2017;27(7):633-646. PubMed PMID: 28502528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural response to catecholamine depletion in remitted bulimia nervosa: Relation to depression and relapse. AU - Mueller,Stefanie Verena, AU - Mihov,Yoan, AU - Federspiel,Andrea, AU - Wiest,Roland, AU - Hasler,Gregor, Y1 - 2017/05/11/ PY - 2016/11/04/received PY - 2017/04/13/revised PY - 2017/04/18/accepted PY - 2017/5/16/pubmed PY - 2018/4/4/medline PY - 2017/5/16/entrez KW - Alpha-methyl-paratyrosine KW - Arterial spin labeling KW - Bulimia nervosa KW - Catecholamine depletion KW - Cerebral blood flow KW - Relapse SP - 633 EP - 646 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 27 IS - 7 N2 - Bulimia nervosa has been associated with a dysregulated catecholamine system. Nevertheless, the influence of this dysregulation on bulimic symptoms, on neural activity, and on the course of the illness is not clear yet. An instructive paradigm for directly investigating the relationship between catecholaminergic functioning and bulimia nervosa has involved the behavioral and neural responses to experimental catecholamine depletion. The purpose of this study was to examine the neural substrate of catecholaminergic dysfunction in bulimia nervosa and its relationship to relapse. In a randomized, double-blind and crossover study design, catecholamine depletion was achieved by using the oral administration of alpha-methyl-paratyrosine (AMPT) over 24 h in 18 remitted bulimic (rBN) and 22 healthy (HC) female participants. Cerebral blood flow (CBF) was measured using a pseudo continuous arterial spin labeling (pCASL) sequence. In a follow-up telephone interview, bulimic relapse was assessed. Following AMPT, rBN participants revealed an increased vigor reduction and CBF decreases in the pallidum and posterior midcingulate cortex (pMCC) relative to HC participants showing no CBF changes in these regions. These results indicated that the pallidum and the pMCC are the functional neural correlates of the dysregulated catecholamine system in bulimia nervosa. Bulimic relapse was associated with increased depressive symptoms and CBF reduction in the hippocampus/parahippocampal gyrus following catecholamine depletion. AMPT-induced increased CBF in this region predicted staying in remission. These findings demonstrated the importance of depressive symptoms and the stress system in the course of bulimia nervosa. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/28502528/Neural_response_to_catecholamine_depletion_in_remitted_bulimia_nervosa:_Relation_to_depression_and_relapse_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(17)30211-0 DB - PRIME DP - Unbound Medicine ER -