Tags

Type your tag names separated by a space and hit enter

Molecular mechanisms of anti-oxidant and anti-aging effects induced by convallatoxin in Caenorhabditis elegans.
Free Radic Res. 2017 May; 51(5):529-544.FR

Abstract

Convallatoxin is widely used as a cardiac glycoside in acute and chronic congestive heart-failure and paroxysmal tachycardia, with many effects and underlying protective mechanisms on inflammation and cellular proliferation. However, convallatoxin has not been investigated in its antioxidant effects and lifespan extension in Caenorhabditis elegans. In this study, we found that convallatoxin (20 μM) could significantly prolong the lifespan of wild-type C. elegans up to 16.3% through daf-16, but not sir-2.1 signalling and increased thermotolerance and resistance to paraquat-induced oxidative stress. Convallatoxin also improved pharyngeal pumping, locomotion, reduced lipofuscin accumulation and reactive oxygen species levels in C. elegans, which were attributed to hormesis, free radical-scavenging effects in vivo, and up-regulation of stress resistance-related proteins, such as SOD-3 and HSP-16.1. Furthermore, aging-associated genes daf-16, sod-3, and ctl-2 also appeared to contribute to the stress-resistance effect of convallatoxin. In summary, this study demonstrates that convallatoxin can protect against heat and oxidative stress and extend the lifespan of C. elegans, pointing it as a potential novel drug for retarding the aging process in humans.

Authors+Show Affiliations

a School of Life Science , Jilin University , Changchun , PR China.a School of Life Science , Jilin University , Changchun , PR China.a School of Life Science , Jilin University , Changchun , PR China.b College of Chemistry , Jilin University , Changchun , PR China.a School of Life Science , Jilin University , Changchun , PR China.a School of Life Science , Jilin University , Changchun , PR China.a School of Life Science , Jilin University , Changchun , PR China.a School of Life Science , Jilin University , Changchun , PR China.a School of Life Science , Jilin University , Changchun , PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28503972

Citation

Xu, Jia, et al. "Molecular Mechanisms of Anti-oxidant and Anti-aging Effects Induced By Convallatoxin in Caenorhabditis Elegans." Free Radical Research, vol. 51, no. 5, 2017, pp. 529-544.
Xu J, Guo Y, Sui T, et al. Molecular mechanisms of anti-oxidant and anti-aging effects induced by convallatoxin in Caenorhabditis elegans. Free Radic Res. 2017;51(5):529-544.
Xu, J., Guo, Y., Sui, T., Wang, Q., Zhang, Y., Zhang, R., Wang, M., Guan, S., & Wang, L. (2017). Molecular mechanisms of anti-oxidant and anti-aging effects induced by convallatoxin in Caenorhabditis elegans. Free Radical Research, 51(5), 529-544. https://doi.org/10.1080/10715762.2017.1331037
Xu J, et al. Molecular Mechanisms of Anti-oxidant and Anti-aging Effects Induced By Convallatoxin in Caenorhabditis Elegans. Free Radic Res. 2017;51(5):529-544. PubMed PMID: 28503972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular mechanisms of anti-oxidant and anti-aging effects induced by convallatoxin in Caenorhabditis elegans. AU - Xu,Jia, AU - Guo,Youming, AU - Sui,Tianzhuo, AU - Wang,Qifei, AU - Zhang,Yue, AU - Zhang,Ruining, AU - Wang,Mingyang, AU - Guan,Shuwen, AU - Wang,Liping, PY - 2017/5/16/pubmed PY - 2018/3/13/medline PY - 2017/5/16/entrez KW - Caenorhabditis elegans KW - Convallatoxin KW - anti-aging KW - antioxidant KW - daf-16 SP - 529 EP - 544 JF - Free radical research JO - Free Radic. Res. VL - 51 IS - 5 N2 - Convallatoxin is widely used as a cardiac glycoside in acute and chronic congestive heart-failure and paroxysmal tachycardia, with many effects and underlying protective mechanisms on inflammation and cellular proliferation. However, convallatoxin has not been investigated in its antioxidant effects and lifespan extension in Caenorhabditis elegans. In this study, we found that convallatoxin (20 μM) could significantly prolong the lifespan of wild-type C. elegans up to 16.3% through daf-16, but not sir-2.1 signalling and increased thermotolerance and resistance to paraquat-induced oxidative stress. Convallatoxin also improved pharyngeal pumping, locomotion, reduced lipofuscin accumulation and reactive oxygen species levels in C. elegans, which were attributed to hormesis, free radical-scavenging effects in vivo, and up-regulation of stress resistance-related proteins, such as SOD-3 and HSP-16.1. Furthermore, aging-associated genes daf-16, sod-3, and ctl-2 also appeared to contribute to the stress-resistance effect of convallatoxin. In summary, this study demonstrates that convallatoxin can protect against heat and oxidative stress and extend the lifespan of C. elegans, pointing it as a potential novel drug for retarding the aging process in humans. SN - 1029-2470 UR - https://www.unboundmedicine.com/medline/citation/28503972/Molecular_mechanisms_of_anti_oxidant_and_anti_aging_effects_induced_by_convallatoxin_in_Caenorhabditis_elegans_ L2 - http://www.tandfonline.com/doi/full/10.1080/10715762.2017.1331037 DB - PRIME DP - Unbound Medicine ER -